BAY607550 [Ligand Id: 5147] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL370962 (BAY-60-7550)
  • phosphodiesterase 2A/Phosphodiesterase 2A in Human [ChEMBL: CHEMBL2652] [GtoPdb: 1297] [UniProtKB: O00408]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
phosphodiesterase 2A/Phosphodiesterase 2A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2652] [GtoPdb: 1297] [UniProtKB: O00408]
ChEMBL Inhibition of PDE2 (unknown origin) using [3H]cAMP or [3H]cGMP as substrate measured after 30 mins by liquid scintillation counting method B 8.32 pIC50 4.8 nM IC50 Bioorg Med Chem Lett (2019) 29: 481-486 [PMID:30554955]
ChEMBL Inhibition of cGMP stimulated human PDE2A B 8.33 pIC50 4.7 nM IC50 MedChemComm (2015) 6: 2063-2080
ChEMBL Inhibition of human His-tagged PDE2A catalytic domain (578 to 919 residues) expressed in Escherichia coli BL21-CodonPlus(DE3) cells using cGMP as substrate by HTRF assay B 8.33 pIC50 4.7 nM IC50 J Med Chem (2016) 59: 7029-7065 [PMID:26908025]
ChEMBL Inhibition of PDE2A (unknown origin) using [3H]cGMP as substrate after 30 mins by scintillation proximity assay B 8.33 pIC50 4.7 nM IC50 J Med Chem (2017) 60: 7677-7702 [PMID:28796496]
ChEMBL Inhibition of PDE2 (unknown origin) using [3H]cAMP as substrate measured after 30 mins by scintillation proximity assay B 8.33 pIC50 4.7 nM IC50 Bioorg Med Chem Lett (2019) 29: 481-486 [PMID:30554955]
ChEMBL Inhibition of human His-tagged PDE2A catalytic domain (578 to 919 residues) expressed in Escherichia coli BL21-CodonPlus(DE3) cells using cGMP as substrate by HTRF assay B 8.33 pIC50 4.7 nM IC50 J Med Chem (2016) 59: 7029-7065 [PMID:26908025]
ChEMBL Inhibition of human phosphodiesterase 2 B 8.33 pIC50 4.7 nM IC50 J. Med. Chem. (2005) 48: 3449-3462 [PMID:15887951]
ChEMBL Inhibition of PDE2A (unknown origin) B 8.33 pIC50 4.7 nM IC50 J Med Chem (2017) 60: 5673-5698 [PMID:28574706]
ChEMBL Inhibition of PDE2a (unknown origin) using cAMP as substrate after 30 mins by Scintillation proximity assay B 8.7 pIC50 2 nM IC50 J Med Chem (2017) 60: 2037-2051 [PMID:28165743]
GtoPdb - - 8.8 pIC50 1.58 nM IC50 Neuropharmacology (2004) 47: 1081-92 [PMID:15555642]
ChEMBL Inhibition of PDE2A (unknown origin) B 9.07 pIC50 0.86 nM IC50 J Med Chem (2017) 60: 7658-7676 [PMID:28759228]
ChEMBL Inhibition of full length recombinant human FLAG-tagged PDE2A3 expressed in sf21 cells using [3H]cGMP as substrate by scintillation proximity assay B 9.3 pIC50 0.5 nM IC50 J Med Chem (2017) 60: 5673-5698 [PMID:28574706]
ChEMBL Inhibition of human PDE2A1 using 3',5'-[3H]cGMP as substrate after 30 mins by scintillation proximity assay B 10.52 pIC50 0.03 nM IC50 J Med Chem (2018) 61: 3626-3640 [PMID:29601185]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]