BAY607550 [Ligand Id: 5147] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL370962 (BAY-60-7550) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| phosphodiesterase 2A/Phosphodiesterase 2A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2652] [GtoPdb: 1297] [UniProtKB: O00408] | ||||||||
| ChEMBL | Inhibition of PDE2 (unknown origin) using [3H]cAMP or [3H]cGMP as substrate measured after 30 mins by liquid scintillation counting method | B | 8.32 | pIC50 | 4.8 | nM | IC50 | Bioorg Med Chem Lett (2019) 29: 481-486 [PMID:30554955] |
| ChEMBL | Inhibition of cGMP stimulated human PDE2A | B | 8.33 | pIC50 | 4.7 | nM | IC50 | Medchemcomm (2015) 6: 2063-2080 |
| ChEMBL | Inhibition of human phosphodiesterase 2 | B | 8.33 | pIC50 | 4.7 | nM | IC50 | J Med Chem (2005) 48: 3449-3462 [PMID:15887951] |
| ChEMBL | Inhibition of PDE2A (unknown origin) | B | 8.33 | pIC50 | 4.7 | nM | IC50 | J Med Chem (2017) 60: 5673-5698 [PMID:28574706] |
| ChEMBL | Inhibition of PDE2A (unknown origin) using [3H]cGMP as substrate after 30 mins by scintillation proximity assay | B | 8.33 | pIC50 | 4.7 | nM | IC50 | J Med Chem (2017) 60: 7677-7702 [PMID:28796496] |
| ChEMBL | Inhibition of PDE2 (unknown origin) using [3H]cAMP as substrate measured after 30 mins by scintillation proximity assay | B | 8.33 | pIC50 | 4.7 | nM | IC50 | Bioorg Med Chem Lett (2019) 29: 481-486 [PMID:30554955] |
| ChEMBL | Inhibition of human His-tagged PDE2A catalytic domain (578 to 919 residues) expressed in Escherichia coli BL21-CodonPlus(DE3) cells using cGMP as substrate by HTRF assay | B | 8.33 | pIC50 | 4.7 | nM | IC50 | J Med Chem (2016) 59: 7029-7065 [PMID:26908025] |
| ChEMBL | Inhibition of PDE2a (unknown origin) using cAMP as substrate after 30 mins by Scintillation proximity assay | B | 8.7 | pIC50 | 2 | nM | IC50 | J Med Chem (2017) 60: 2037-2051 [PMID:28165743] |
| GtoPdb | - | - | 8.8 | pIC50 | 1.58 | nM | IC50 | Neuropharmacology (2004) 47: 1081-92 [PMID:15555642] |
| ChEMBL | Inhibition of PDE2A (unknown origin) | B | 9.07 | pIC50 | 0.86 | nM | IC50 | J Med Chem (2017) 60: 7658-7676 [PMID:28759228] |
| ChEMBL | Inhibition of full length recombinant human FLAG-tagged PDE2A3 expressed in sf21 cells using [3H]cGMP as substrate by scintillation proximity assay | B | 9.3 | pIC50 | 0.5 | nM | IC50 | J Med Chem (2017) 60: 5673-5698 [PMID:28574706] |
| ChEMBL | Inhibition of human PDE2A1 using 3',5'-[3H]cGMP as substrate after 30 mins by scintillation proximity assay | B | 10.52 | pIC50 | 0.03 | nM | IC50 | J Med Chem (2018) 61: 3626-3640 [PMID:29601185] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
