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ChEMBL ligand: CHEMBL682 (NSC-13453, Amodiaquine, GNF-Pf-5648, SJ000110703, Amodiaquin) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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Beta amyloid A4 protein in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2487] [UniProtKB: P05067] | ||||||||
ChEMBL | Modulation of human wild-type APP695 expressed in SH-SY5Y cells assessed as inhibition of amyloid beta (1 to 42 residues) production measured after 24 hrs by ELISA | B | 5.27 | pIC50 | 5400 | nM | IC50 | Bioorg Med Chem (2018) 26: 2151-2164 [PMID:29559198] |
ChEMBL | Modulation of human wild-type APP695 expressed in SH-SY5Y cells assessed as inhibition of amyloid beta (1 to 40 residues) production measured after 24 hrs | B | 5.4 | pIC50 | 4000 | nM | IC50 | Bioorg Med Chem (2018) 26: 2151-2164 [PMID:29559198] |
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364] | ||||||||
ChEMBL | Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2 infected in human A+ erythrocytes assessed as inhibition of [3H]-hypoxanthine incorporation after 42 hrs by beta counting method | F | 8.22 | pIC50 | 6 | nM | IC50 | Eur J Med Chem (2017) 126: 72-83 [PMID:27744189] |
ChEMBL | Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2 infected in human A+ erythrocytes after 48 hrs by SYBR Green based fluorescence assay | F | 8.22 | pIC50 | 6 | nM | IC50 | Eur J Med Chem (2017) 126: 72-83 [PMID:27744189] |
ChEMBL | Antiplasmodial activity against Plasmodium falciparum W2 infected in human erythrocytes after 48 hrs by [3H]-hypoxanthine incorporation assay | F | 8.3 | pIC50 | 5 | nM | IC50 | Bioorg. Med. Chem. (2015) 23: 5419-5432 [PMID:26264839] |
ChEMBL | Antimalarial activity against chloroquine-resistant Plasmodium falciparum Dd2 infected in human erythrocyte assessed as growth inhibition by SYBR Green-1 assay | F | 7.91 | pEC50 | 12.3 | nM | EC50 | Eur. J. Med. Chem. (2015) 102: 320-333 [PMID:26295174] |
Plasmodium falciparum 3D7 (target type: ORGANISM) [ChEMBL: CHEMBL2366922] | ||||||||
ChEMBL | Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in human erythrocyte assessed as growth inhibition by SYBR Green-1 assay | F | 8.23 | pEC50 | 5.85 | nM | EC50 | Eur. J. Med. Chem. (2015) 102: 320-333 [PMID:26295174] |
Plasmodium falciparum (isolate K1 / Thailand) in Plasmodium falciparum K1 (target type: ORGANISM) [ChEMBL: CHEMBL612856] | ||||||||
ChEMBL | Antiplasmodial activity against multidrug-resistant Plasmodium falciparum K1 infected in human erythrocytes after 48 hrs by [3H]-hypoxanthine incorporation assay | F | 8.1 | pIC50 | 8 | nM | IC50 | Bioorg. Med. Chem. (2015) 23: 5419-5432 [PMID:26264839] |
Plasmodium falciparum NF54 (target type: ORGANISM) [ChEMBL: CHEMBL2367131] | ||||||||
ChEMBL | Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum NF54 infected in human erythrocytes after 48 hrs by [3H]-hypoxanthine incorporation assay | F | 8.4 | pIC50 | 4 | nM | IC50 | Bioorg. Med. Chem. (2015) 23: 5419-5432 [PMID:26264839] |
ChEMBL data shown on this page come from version 27:
Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]