amodiaquine [Ligand Id: 10018] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL682 (NSC-13453, Amodiaquine, GNF-Pf-5648, SJ000110703, Amodiaquin)
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  • Plasmodium falciparum (isolate K1 / Thailand) in Plasmodium falciparum K1 [ChEMBL: CHEMBL612856]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Beta amyloid A4 protein in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2487] [UniProtKB: P05067]
ChEMBL Modulation of human wild-type APP695 expressed in SH-SY5Y cells assessed as inhibition of amyloid beta (1 to 42 residues) production measured after 24 hrs by ELISA B 5.27 pIC50 5400 nM IC50 Bioorg Med Chem (2018) 26: 2151-2164 [PMID:29559198]
ChEMBL Modulation of human wild-type APP695 expressed in SH-SY5Y cells assessed as inhibition of amyloid beta (1 to 40 residues) production measured after 24 hrs B 5.4 pIC50 4000 nM IC50 Bioorg Med Chem (2018) 26: 2151-2164 [PMID:29559198]
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364]
ChEMBL Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2 infected in human A+ erythrocytes assessed as inhibition of [3H]-hypoxanthine incorporation after 42 hrs by beta counting method F 8.22 pIC50 6 nM IC50 Eur J Med Chem (2017) 126: 72-83 [PMID:27744189]
ChEMBL Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2 infected in human A+ erythrocytes after 48 hrs by SYBR Green based fluorescence assay F 8.22 pIC50 6 nM IC50 Eur J Med Chem (2017) 126: 72-83 [PMID:27744189]
ChEMBL Antiplasmodial activity against Plasmodium falciparum W2 infected in human erythrocytes after 48 hrs by [3H]-hypoxanthine incorporation assay F 8.3 pIC50 5 nM IC50 Bioorg. Med. Chem. (2015) 23: 5419-5432 [PMID:26264839]
ChEMBL Antimalarial activity against chloroquine-resistant Plasmodium falciparum Dd2 infected in human erythrocyte assessed as growth inhibition by SYBR Green-1 assay F 7.91 pEC50 12.3 nM EC50 Eur. J. Med. Chem. (2015) 102: 320-333 [PMID:26295174]
Plasmodium falciparum 3D7 (target type: ORGANISM) [ChEMBL: CHEMBL2366922]
ChEMBL Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in human erythrocyte assessed as growth inhibition by SYBR Green-1 assay F 8.23 pEC50 5.85 nM EC50 Eur. J. Med. Chem. (2015) 102: 320-333 [PMID:26295174]
Plasmodium falciparum (isolate K1 / Thailand) in Plasmodium falciparum K1 (target type: ORGANISM) [ChEMBL: CHEMBL612856]
ChEMBL Antiplasmodial activity against multidrug-resistant Plasmodium falciparum K1 infected in human erythrocytes after 48 hrs by [3H]-hypoxanthine incorporation assay F 8.1 pIC50 8 nM IC50 Bioorg. Med. Chem. (2015) 23: 5419-5432 [PMID:26264839]
Plasmodium falciparum NF54 (target type: ORGANISM) [ChEMBL: CHEMBL2367131]
ChEMBL Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum NF54 infected in human erythrocytes after 48 hrs by [3H]-hypoxanthine incorporation assay F 8.4 pIC50 4 nM IC50 Bioorg. Med. Chem. (2015) 23: 5419-5432 [PMID:26264839]

ChEMBL data shown on this page come from version 27:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]