ChEMBL ligand: CHEMBL682 (NSC-13453, Amodiaquine, GNF-Pf-5648, SJ000110703, Amodiaquin)
Beta amyloid A4 protein in Human [ChEMBL: CHEMBL2487] [UniProtKB: P05067] There should be some charts here, you may need to enable JavaScript!
Plasmodium falciparum [ChEMBL: CHEMBL364] There should be some charts here, you may need to enable JavaScript!
Plasmodium falciparum 3D7 [ChEMBL: CHEMBL2366922] There should be some charts here, you may need to enable JavaScript!
Plasmodium falciparum (isolate K1 / Thailand) in Plasmodium falciparum K1 [ChEMBL: CHEMBL612856] There should be some charts here, you may need to enable JavaScript!
Plasmodium falciparum NF54 [ChEMBL: CHEMBL2367131] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
Beta amyloid A4 protein in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2487] [UniProtKB: P05067]
ChEMBL	Modulation of human wild-type APP695 expressed in SH-SY5Y cells assessed as inhibition of amyloid beta (1 to 42 residues) production measured after 24 hrs by ELISA	B	5.27	pIC50	5400	nM	IC50	Bioorg Med Chem (2018) 26: 2151-2164 [PMID:29559198]
ChEMBL	Modulation of human wild-type APP695 expressed in SH-SY5Y cells assessed as inhibition of amyloid beta (1 to 40 residues) production measured after 24 hrs	B	5.4	pIC50	4000	nM	IC50	Bioorg Med Chem (2018) 26: 2151-2164 [PMID:29559198]
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2 infected in human A+ erythrocytes assessed as inhibition of [3H]-hypoxanthine incorporation after 42 hrs by beta counting method	F	8.22	pIC50	6	nM	IC50	Eur J Med Chem (2017) 126: 72-83 [PMID:27744189]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2 infected in human A+ erythrocytes after 48 hrs by SYBR Green based fluorescence assay	F	8.22	pIC50	6	nM	IC50	Eur J Med Chem (2017) 126: 72-83 [PMID:27744189]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum W2 infected in human erythrocytes after 48 hrs by [3H]-hypoxanthine incorporation assay	F	8.3	pIC50	5	nM	IC50	Bioorg. Med. Chem. (2015) 23: 5419-5432 [PMID:26264839]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum Dd2 infected in human erythrocyte assessed as growth inhibition by SYBR Green-1 assay	F	7.91	pEC50	12.3	nM	EC50	Eur. J. Med. Chem. (2015) 102: 320-333 [PMID:26295174]
Plasmodium falciparum 3D7 (target type: ORGANISM) [ChEMBL: CHEMBL2366922]
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in human erythrocyte assessed as growth inhibition by SYBR Green-1 assay	F	8.23	pEC50	5.85	nM	EC50	Eur. J. Med. Chem. (2015) 102: 320-333 [PMID:26295174]
Plasmodium falciparum (isolate K1 / Thailand) in Plasmodium falciparum K1 (target type: ORGANISM) [ChEMBL: CHEMBL612856]
ChEMBL	Antiplasmodial activity against multidrug-resistant Plasmodium falciparum K1 infected in human erythrocytes after 48 hrs by [3H]-hypoxanthine incorporation assay	F	8.1	pIC50	8	nM	IC50	Bioorg. Med. Chem. (2015) 23: 5419-5432 [PMID:26264839]
Plasmodium falciparum NF54 (target type: ORGANISM) [ChEMBL: CHEMBL2367131]
ChEMBL	Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum NF54 infected in human erythrocytes after 48 hrs by [3H]-hypoxanthine incorporation assay	F	8.4	pIC50	4	nM	IC50	Bioorg. Med. Chem. (2015) 23: 5419-5432 [PMID:26264839]

ChEMBL data shown on this page come from version 27:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]