amodiaquine [Ligand Id: 10018] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL682 (Amodiaquin, Amodiaquine, Amodiaquinum, GNF-Pf-5648, NSC-13453, SJ000110703, Sunoquine) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Beta amyloid A4 protein in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2487] [UniProtKB: P05067] | ||||||||
| ChEMBL | Modulation of human wild-type APP695 expressed in SH-SY5Y cells assessed as inhibition of amyloid beta (1 to 42 residues) production measured after 24 hrs by ELISA | B | 5.27 | pIC50 | 5400 | nM | IC50 | Bioorg Med Chem (2018) 26: 2151-2164 [PMID:29559198] |
| ChEMBL | Modulation of human wild-type APP695 expressed in SH-SY5Y cells assessed as inhibition of amyloid beta (1 to 40 residues) production measured after 24 hrs | B | 5.4 | pIC50 | 4000 | nM | IC50 | Bioorg Med Chem (2018) 26: 2151-2164 [PMID:29559198] |
| Hemozoin in Plasmodium falciparum (target type: MACROMOLECULE) [ChEMBL: CHEMBL613898] | ||||||||
| ChEMBL | Inhibition of beta-hematin | B | 4.68 | pIC50 | 21000 | nM | IC50 | J Med Chem (2016) 59: 6512-6530 [PMID:27299916] |
| ChEMBL | Inhibition of beta-hematin formation assessed as reduction in hemozoin formation incubated for 5 hrs by NP40 detergent-based assay | B | 4.89 | pIC50 | 13000 | nM | IC50 | Medchemcomm (2019) 10: 450-455 [PMID:31015908] |
| Nuclear receptor related 1/Nuclear receptor subfamily 4 group A member 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5002] [GtoPdb: 630] [UniProtKB: P43354] | ||||||||
| ChEMBL | Agonist activity at Gal4-fused human Nurr1 LBD expressed in HEK293T cells co-expressing firefly luciferase assessed as luciferase activity in presence of 5-(Pyridin-3-yl)-1-methylindole-3-carboxylic Acid Methyl Ester by hybrid reporter gene assay | B | 4.09 | pEC50 | 82000 | nM | EC50 | J Med Chem (2021) 64: 15126-15140 [PMID:34633810] |
| ChEMBL | Agonist activity at Gal4-fused human Nurr1 LBD expressed in HEK293T cells co-expressing firefly luciferase assessed as luciferase activity by hybrid reporter gene assay | B | 4.39 | pEC50 | 41000 | nM | EC50 | J Med Chem (2021) 64: 15126-15140 [PMID:34633810] |
| ChEMBL | Agonist activity at Gal4-fused human Nurr1 LBD expressed in HEK293T cells co-expressing firefly luciferase assessed as luciferase activity incubated for 12 to 14 hrs by hybrid reporter gene assay | B | 4.44 | pEC50 | 36000 | nM | EC50 | J Med Chem (2021) 64: 2659-2668 [PMID:33629841] |
| Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364] | ||||||||
| ChEMBL | Antimalarial activity against Plasmodium falciparum 3D7 asexual forms incubated for 72 hrs by luminescence method | F | 4.75 | pIC50 | 17900 | nM | IC50 | Eur J Med Chem (2020) 188: 111983-111983 [PMID:31911292] |
| ChEMBL | Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2 infected in human A+ erythrocytes assessed as inhibition of [3H]-hypoxanthine incorporation after 42 hrs by beta counting method | F | 8.22 | pIC50 | 6 | nM | IC50 | Eur J Med Chem (2017) 126: 72-83 [PMID:27744189] |
| ChEMBL | Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2 infected in human A+ erythrocytes after 48 hrs by SYBR Green based fluorescence assay | F | 8.22 | pIC50 | 6 | nM | IC50 | Eur J Med Chem (2017) 126: 72-83 [PMID:27744189] |
| ChEMBL | Antimalarial activity against chloroquine-resistant and mefloquine-sensitive Plasmodium falciparum W2 ring stage form infected in human erythrocytes by spectrophotometric analysis | F | 8.22 | pIC50 | 6 | nM | IC50 | Bioorg Med Chem (2019) 27: 1002-1008 [PMID:30737133] |
| ChEMBL | Antiplasmodial activity against Plasmodium falciparum W2 infected in human erythrocytes after 48 hrs by [3H]-hypoxanthine incorporation assay | F | 8.3 | pIC50 | 5 | nM | IC50 | Bioorg Med Chem (2015) 23: 5419-5432 [PMID:26264839] |
| ChEMBL | Antimalarial activity against chloroquine-resistant Plasmodium falciparum Dd2 infected in human erythrocyte assessed as growth inhibition by SYBR Green-1 assay | F | 7.91 | pEC50 | 12.3 | nM | EC50 | Eur J Med Chem (2015) 102: 320-333 [PMID:26295174] |
| Plasmodium falciparum 3D7 (target type: ORGANISM) [ChEMBL: CHEMBL2366922] | ||||||||
| ChEMBL | Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in human erythrocyte assessed as growth inhibition by SYBR Green-1 assay | F | 8.23 | pEC50 | 5.85 | nM | EC50 | Eur J Med Chem (2015) 102: 320-333 [PMID:26295174] |
| Plasmodium falciparum (isolate K1 / Thailand) in Plasmodium falciparum K1 (target type: ORGANISM) [ChEMBL: CHEMBL612856] | ||||||||
| ChEMBL | Antiplasmodial activity against multidrug-resistant Plasmodium falciparum K1 infected in human erythrocytes after 48 hrs by [3H]-hypoxanthine incorporation assay | F | 8.1 | pIC50 | 8 | nM | IC50 | Bioorg Med Chem (2015) 23: 5419-5432 [PMID:26264839] |
| Plasmodium falciparum NF54 (target type: ORGANISM) [ChEMBL: CHEMBL2367131] | ||||||||
| ChEMBL | Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum NF54 infected in human erythrocytes after 48 hrs by [3H]-hypoxanthine incorporation assay | F | 8.4 | pIC50 | 4 | nM | IC50 | Bioorg Med Chem (2015) 23: 5419-5432 [PMID:26264839] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
