PF-03463275 [Ligand Id: 9057] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL563251 (Pf-03463275, Pf-3463275) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| GlyT1/Glycine transporter 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2337] [GtoPdb: 935] [UniProtKB: P48067] | ||||||||
| ChEMBL | Binding affinity to GlyT1 | B | 7.94 | pKi | 11.6 | nM | Ki | Bioorg Med Chem Lett (2009) 19: 2974-2976 [PMID:19410451] |
| GtoPdb | - | - | 7.94 | pKi | 11.6 | nM | Ki | Bioorg Med Chem Lett (2009) 19: 2974-6 [PMID:19410451] |
| GlyT2/Glycine transporter 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3060] [GtoPdb: 936] [UniProtKB: Q9Y345] | ||||||||
| ChEMBL | Displacement of [3H]glycine from GlyT2 | B | 5 | pIC50 | >10000 | nM | IC50 | Bioorg Med Chem Lett (2009) 19: 2974-2976 [PMID:19410451] |
| Kv11.1/HERG in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809] | ||||||||
| ChEMBL | Inhibition human ERG expressed in HEK293 cells assessed as blockade of membrane current by patch clamp method | B | 5.07 | pIC50 | 8500 | nM | IC50 | Bioorg Med Chem Lett (2009) 19: 2974-2976 [PMID:19410451] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
