PF-03463275 [Ligand Id: 9057] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL563251 (Pf-03463275, Pf-3463275) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| GlyT1/Glycine transporter 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2337] [GtoPdb: 935] [UniProtKB: P48067] | ||||||||
| ChEMBL | Binding affinity to GlyT1 | B | 7.94 | pKi | 11.6 | nM | Ki | Bioorg Med Chem Lett (2009) 19: 2974-2976 [PMID:19410451] |
| GtoPdb | - | - | 7.94 | pKi | 11.6 | nM | Ki | Bioorg Med Chem Lett (2009) 19: 2974-6 [PMID:19410451] |
| GlyT2/Glycine transporter 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3060] [GtoPdb: 936] [UniProtKB: Q9Y345] | ||||||||
| ChEMBL | Displacement of [3H]glycine from GlyT2 | B | 5 | pIC50 | >10000 | nM | IC50 | Bioorg Med Chem Lett (2009) 19: 2974-2976 [PMID:19410451] |
| Kv11.1/HERG in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809] | ||||||||
| ChEMBL | Inhibition human ERG expressed in HEK293 cells assessed as blockade of membrane current by patch clamp method | B | 5.07 | pIC50 | 8500 | nM | IC50 | Bioorg Med Chem Lett (2009) 19: 2974-2976 [PMID:19410451] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
