Ro3280 [Ligand Id: 9403] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL2392553
  • polo like kinase 1/Serine/threonine-protein kinase PLK1 in Human [ChEMBL: CHEMBL3024] [GtoPdb: 2168] [UniProtKB: P53350]
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  • FER tyrosine kinase in Human [GtoPdb: 2022] [UniProtKB: P16591]
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  • TTK protein kinase in Human [GtoPdb: 2264] [UniProtKB: P33981]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
polo like kinase 1/Serine/threonine-protein kinase PLK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3024] [GtoPdb: 2168] [UniProtKB: P53350]
GtoPdb Ambit selectivity screen at 1μM Ro3280. - 10.05 pKd 0.09 nM Kd Bioorg Med Chem Lett (2012) 22: 1247-50 [PMID:22172702]
ChEMBL Inhibition of PLK1 (unknown origin) using biotin-AGAGTVPESIHSFIGDGLV as substrate by TR-FRET assay B 8.4 pIC50 4 nM IC50 Bioorg. Med. Chem. Lett. (2013) 23: 3662-3666 [PMID:23664874]
GtoPdb In a biochemical enzymatic assay. - 8.52 pIC50 3 nM IC50 Bioorg Med Chem Lett (2012) 22: 1247-50 [PMID:22172702]
FER tyrosine kinase in Human [GtoPdb: 2022] [UniProtKB: P16591]
GtoPdb Ambit selectivity screen at 1μM Ro3280. - 7.28 pKd 53 nM Kd Bioorg Med Chem Lett (2012) 22: 1247-50 [PMID:22172702]
TTK protein kinase in Human [GtoPdb: 2264] [UniProtKB: P33981]
GtoPdb Ambit selectivity screen at 1μM Ro3280. - 7.29 pKd 51 nM Kd Bioorg Med Chem Lett (2012) 22: 1247-50 [PMID:22172702]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]