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ChEMBL ligand: CHEMBL566534 (Artemether, Artemetheri, Artemetherum, Artesaph, .beta.-artemether, Dihydroartemisinin impurity g, Falcidol, Gvither, Larither, Malartem, NSC-665970, NSC-759820, Paluther, SM 224) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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Plasmodium berghei (target type: ORGANISM) [ChEMBL: CHEMBL612653] | ||||||||
ChEMBL | Antiplasmodial activity against Plasmodium berghei ANKA early trophozoite stage by parasite LDH assay | F | 8.52 | pIC50 | 3 | nM | IC50 | J Med Chem (2015) 58: 7895-7899 [PMID:26367273] |
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364] | ||||||||
ChEMBL | In vitro anti-protozoal activity against Plasmodium falciparum Ghana | F | 7.6 | pIC50 | 25 | nM | IC50 | Bioorg Med Chem Lett (2003) 13: 2013-2015 [PMID:12781185] |
ChEMBL | Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum K1 infected in human O-positive erythrocytes assessed as decrease in parasitaemia after 72 hrs by NBT dye-based spectrophotometric method | F | 7.7 | pIC50 | 20 | nM | IC50 | Eur J Med Chem (2018) 143: 306-319 [PMID:29197735] |
ChEMBL | In vitro antimalarial activity against Plasmodium falciparum FCR3 | F | 7.85 | pIC50 | 14 | nM | IC50 | Bioorg Med Chem Lett (2003) 13: 75-77 [PMID:12467620] |
ChEMBL | In vitro inhibitory concentration against chloroquine-sensitive Plasmodium falciparum HB3 | F | 8.04 | pIC50 | 9.2 | nM | IC50 | J Med Chem (2002) 45: 1052-1063 [PMID:11855985] |
ChEMBL | In vitro inhibitory concentration against chloroquine-resistant Plasmodium falciparum K1 | F | 8.1 | pIC50 | 7.94 | nM | IC50 | J Med Chem (2002) 45: 1052-1063 [PMID:11855985] |
ChEMBL | In vitro inhibitory concentration against chloroquine-resistant Plasmodium falciparum K1 | F | 8.19 | pIC50 | 6.5 | nM | IC50 | J Med Chem (2002) 45: 1052-1063 [PMID:11855985] |
ChEMBL | In vitro antimalarial activity for Plasmodium falciparum W-2 | F | 8.27 | pIC50 | 5.4 | nM | IC50 | J Med Chem (1998) 41: 4101-4108 [PMID:9767645] |
ChEMBL | In vitro inhibitory activity against the chloroquine-resistant Plasmodium falciparum W2 Indochina | F | 8.27 | pIC50 | 5.4 | nM | IC50 | Bioorg Med Chem Lett (2003) 13: 1059-1062 [PMID:12643911] |
ChEMBL | In vitro antimalarial activity against chloroquine-resistant Plasmodium falciparum K1 | F | 8.34 | pIC50 | 4.55 | nM | IC50 | J Med Chem (2001) 44: 58-68 [PMID:11141088] |
ChEMBL | Antimalarial activity against multidrug resistant Plasmodium falciparum W2 infected in human erythrocytes assessed as inhibition of parasite proliferation after 96 hrs by SYBR Green I fluorescence based assay | F | 8.35 | pIC50 | 4.5 | nM | IC50 | Bioorg Med Chem Lett (2016) 26: 3006-3009 [PMID:27210430] |
ChEMBL | Inhibitory concentration against Plasmodium falciparum D6 (Sierra Leone) | F | 8.35 | pIC50 | 4.49 | nM | IC50 | J Med Chem (1988) 31: 645-650 [PMID:3279208] |
ChEMBL | Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 assessed as growth inhibition by [3H]hypoxanthine incorporation assay | F | 8.38 | pIC50 | 4.2 | nM | IC50 | J Med Chem (2010) 53: 633-640 [PMID:19957999] |
ChEMBL | Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum NF54 by LDH assay | F | 8.42 | pIC50 | 3.8 | nM | IC50 | Bioorg Med Chem Lett (2020) 30: 127581-127581 [PMID:32987134] |
ChEMBL | Antimalarial activity after 48 hrs against chloroquine-sensitive Plasmodium falciparum 3D7 by [3H]hypoxanthine uptake | F | 8.45 | pIC50 | 3.53 | nM | IC50 | Bioorg Med Chem Lett (2009) 19: 2033-2037 [PMID:19249201] |
ChEMBL | Antimalarial activity against chloroquine-resistant Plasmodium falciparum K1 by [3H]hypoxanthine uptake | F | 8.45 | pIC50 | 3.53 | nM | IC50 | Bioorg Med Chem (2009) 17: 1325-1338 [PMID:19136263] |
ChEMBL | In vitro inhibitory concentration against chloroquine-resistant Plasmodium falciparum FcB1 | F | 8.46 | pIC50 | 3.5 | nM | IC50 | J Med Chem (2004) 47: 1423-1433 [PMID:14998331] |
ChEMBL | Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected type A+ human erythrocytes after 24 hrs by [G-3H]hypoxanthine uptake | F | 8.46 | pIC50 | 3.45 | nM | IC50 | Bioorg Med Chem Lett (2009) 19: 2038-2043 [PMID:19251414] |
ChEMBL | In vitro antimalarial activity against chloroquine-sensitive Plasmodium falciparum HB3 | F | 8.47 | pIC50 | 3.42 | nM | IC50 | J Med Chem (2001) 44: 58-68 [PMID:11141088] |
ChEMBL | Inhibitory concentration against Plasmodium falciparum W2 Indochina | F | 8.48 | pIC50 | 3.34 | nM | IC50 | J Med Chem (1988) 31: 645-650 [PMID:3279208] |
ChEMBL | Antimalarial activity against Plasmodium falciparum 3D7 | F | 8.49 | pIC50 | 3.2 | nM | IC50 | J Med Chem (2008) 51: 2170-2177 [PMID:18341274] |
ChEMBL | Antimalarial activity against Plasmodium falciparum 3D7 | F | 8.49 | pIC50 | 3.2 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 1720-1724 [PMID:18243702] |
ChEMBL | Antiparasitic activity against chloroquine-sensitive Plasmodium falciparum by [3H]hypoxanthine incorporation | F | 8.55 | pIC50 | 2.8 | nM | IC50 | J Med Chem (2008) 51: 1260-1277 [PMID:18260613] |
ChEMBL | Intrinsic equimolar activity against Plasmodium falciparum D6 (Sierra Leone) relative to QHS | F | 8.63 | pIC50 | 2.34 | nM | IC50 | J Med Chem (1988) 31: 645-650 [PMID:3279208] |
ChEMBL | Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum Dd2 by LDH assay | F | 8.64 | pIC50 | 2.3 | nM | IC50 | Bioorg Med Chem Lett (2020) 30: 127581-127581 [PMID:32987134] |
ChEMBL | Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 by [3H]hypoxanthine uptake | F | 8.68 | pIC50 | 2.11 | nM | IC50 | Bioorg Med Chem (2009) 17: 1325-1338 [PMID:19136263] |
ChEMBL | Intrinsic equimolar activity against Plasmodium falciparum W2 Indochina relative to QHS | F | 8.72 | pIC50 | 1.92 | nM | IC50 | J Med Chem (1988) 31: 645-650 [PMID:3279208] |
ChEMBL | Antimalarial activity against Plasmodium falciparum 3D7 infected human erythrocytes after 24 hrs by [3H]hypoxanthine uptake | F | 8.9 | pIC50 | 1.26 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 5804-5804 [PMID:18845438] |
Plasmodium falciparum (isolate K1 / Thailand) in Plasmodium falciparum K1 (target type: ORGANISM) [ChEMBL: CHEMBL612856] | ||||||||
ChEMBL | Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum K1 infected in human O positive erythrocyte assessed as reduction in parasitemia after 72 hrs | F | 4.19 | pIC50 | >64000 | nM | IC50 | Bioorg Med Chem (2014) 22: 5241-5248 [PMID:25199582] |
ChEMBL | Antimalarial activity against multidrug resistant Plasmodium falciparum K1 infected in human erythrocytes assessed as inhibition of parasite proliferation after 96 hrs by SYBR Green I fluorescence based assay | F | 8.14 | pIC50 | 7.26 | nM | IC50 | Bioorg Med Chem Lett (2016) 26: 3006-3009 [PMID:27210430] |
ChEMBL | Antimalarial activity against chloroquine-resistant Plasmodium falciparum K1 (Thailand) assessed as growth inhibition by [3H]hypoxanthine incorporation assay | F | 8.47 | pIC50 | 3.4 | nM | IC50 | J Med Chem (2010) 53: 633-640 [PMID:19957999] |
ChEMBL | Antimalarial activity against chloroquine-resistant Plasmodium falciparum K1 | F | 8.6 | pIC50 | 2.5 | nM | IC50 | Antimicrob Agents Chemother (2008) 52: 1291-1296 [PMID:18268087] |
ChEMBL | Antimalarial activity against chloroquine-resistant Plasmodium falciparum K1 infected type A+ human erythrocytes after 24 hrs by [G-3H]hypoxanthine uptake | F | 8.9 | pIC50 | 1.26 | nM | IC50 | Bioorg Med Chem Lett (2009) 19: 2038-2043 [PMID:19251414] |
Plasmodium falciparum NF54 (target type: ORGANISM) [ChEMBL: CHEMBL2367131] | ||||||||
ChEMBL | Antimalarial activity against chloroquine-sensitive asexual Plasmodium falciparum NF54 infected in human erythrocytes assessed as inhibition of parasite proliferation after 96 hrs by SYBR Green I fluorescence based assay | F | 8.24 | pIC50 | 5.77 | nM | IC50 | Bioorg Med Chem Lett (2016) 26: 3006-3009 [PMID:27210430] |
Plasmodium yoelii (target type: ORGANISM) [ChEMBL: CHEMBL612889] | ||||||||
ChEMBL | Antimalarial activity against sporozoite stage of Plasmodium yoelii assessed as invasion of human HepG2 cells expressing CD81 incubated for 2 hrs prior to inoculation measured after 1 hr by immunofluorescence assay in presence of penicillin/streptomycin | F | 6 | pIC50 | <1000 | nM | IC50 | J Med Chem (2013) 56: 7761-7771 [PMID:23927658] |
ChEMBL data shown on this page come from version 32:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]