cyclopiazonic acid [Ligand Id: 5350] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL480627 (Alpha-Cyclopiazonic Acid, Cyclopiazonic Acid)
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  • SERCA1/Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 in Human [ChEMBL: CHEMBL3136] [GtoPdb: 840] [UniProtKB: O14983]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364]
ChEMBL Antimalarial activity against Plasmodium falciparum 3D7 F 5.06 pIC50 8800 nM IC50 Bioorg Med Chem Lett (2018) 28: 298-301 [PMID:29292225]
ChEMBL Antimalarial activity against Plasmodium falciparum FcB1 F 5.31 pIC50 4900 nM IC50 Bioorg Med Chem Lett (2018) 28: 298-301 [PMID:29292225]
ChEMBL Antimalarial activity against NITD609-resistant Plasmodium falciparum Dd2 Clone2 bearing P-type ATPase4 T418N and P990R mutations after 72 hrs by SYBR green based fluorescence assay F 5.38 pIC50 4160 nM IC50 Science (2010) 329: 1175-1180 [PMID:20813948]
ChEMBL Antimalarial activity against NITD609-resistant Plasmodium falciparum Dd2 Clone1 bearing P-type ATPase4 I398F and P990R mutations after 72 hrs by SYBR green based fluorescence assay F 5.46 pIC50 3460 nM IC50 Science (2010) 329: 1175-1180 [PMID:20813948]
ChEMBL Antimalarial activity against Plasmodium falciparum Dd2 after 72 hrs by SYBR green based fluorescence assay F 5.47 pIC50 3417 nM IC50 Science (2010) 329: 1175-1180 [PMID:20813948]
ChEMBL Antimalarial activity against NITD609-resistant Plasmodium falciparum Dd2 Clone3 bearing P-type ATPase4 D1247Y mutations after 72 hrs by SYBR green based fluorescence assay F 5.49 pIC50 3240 nM IC50 Science (2010) 329: 1175-1180 [PMID:20813948]
SERCA1/Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3136] [GtoPdb: 840] [UniProtKB: O14983]
ChEMBL Inhibition of SERCA1a (unknown origin) ATPase activity B 5.74 pKi 1800 nM Ki Bioorg Med Chem Lett (2018) 28: 298-301 [PMID:29292225]

ChEMBL data shown on this page come from version 31:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]