(R)-asimilobine [Ligand Id: 13235] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL469423 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Acetylcholinesterase in Electrophorus electricus (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4078] [UniProtKB: O42275] | ||||||||
| ChEMBL | Inhibition of electric eel AChE by Ellman's assay | B | 4 | pIC50 | >100000 | nM | IC50 | J Nat Prod (2006) 69: 1341-1346 [PMID:16989531] |
| acetylcholinesterase (Yt blood group)/Acetylcholinesterase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL220] [GtoPdb: 2465] [UniProtKB: P22303] | ||||||||
| ChEMBL | Inhibition of human AChE by Ellman's assay | B | 4 | pIC50 | >100000 | nM | IC50 | J Nat Prod (2006) 69: 1341-1346 [PMID:16989531] |
| Cholinesterase in Equus caballus (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5763] [UniProtKB: P81908] | ||||||||
| ChEMBL | Inhibition of horse serum BuChE by Ellman's method | B | 4 | pIC50 | >100000 | nM | IC50 | J Nat Prod (2006) 69: 1341-1346 [PMID:16989531] |
| ChEMBL | Inhibition of equine serum BuChE using BTCI as substrate pre-incubated for 10 mins followed by substrate addition measured after 5 mins by microplate reader analysis | B | 5 | pIC50 | 10080 | nM | IC50 | Eur J Med Chem (2023) 256: 115414-115414 [PMID:37172474] |
| D1 receptor/Dopamine D1 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2056] [GtoPdb: 214] [UniProtKB: P21728] | ||||||||
| ChEMBL | Antagonist activity at D1R (unknown origin) transfected in HEK293 cells by FLIPR assay | F | 5.14 | pIC50 | 7200 | nM | IC50 | Eur J Med Chem (2023) 256: 115414-115414 [PMID:37172474] |
| D2 receptor/Dopamine D2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL217] [GtoPdb: 215] [UniProtKB: P14416] | ||||||||
| ChEMBL | Antagonist activity at D2R (unknown origin) transfected in HEK293 cells by FLIPR assay | F | 5.24 | pIC50 | 5730 | nM | IC50 | Eur J Med Chem (2023) 256: 115414-115414 [PMID:37172474] |
| 5-HT2C receptor/Serotonin 2c (5-HT2c) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL225] [GtoPdb: 8] [UniProtKB: P28335] | ||||||||
| ChEMBL | Partial agonist activity at human 5-HT2C stably transfected in HEK293T cells measured after 18 to 24 hrs by FLIPR assay | F | 6.19 | pEC50 | 653 | nM | EC50 | Eur J Med Chem (2023) 256: 115414-115414 [PMID:37172474] |
| ChEMBL | Partial agonist activity at 5-HT2CR (unknown origin) expressed in HEK293T cells assessed as increase in calcium flux measured for 3 mins by FLIPR assay | F | 6.51 | pEC50 | 308 | nM | EC50 | ACS Med Chem Lett (2024) 15: 99-106 [PMID:38229745] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
