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Synonyms: OLT-1177 | OLT1177
Compound class: Synthetic organic
Comment: Dapansutrile (OLT1177) acts as a NLRP3 inflammasome inhibitor. It is a clinical candidate that is being developed by Olatec Therapeutics. Inhibition of the NLRP3 inflammasome reduces maturation of the pro-inflammatory, disease-associated cytokines IL-1β and IL-18 . Immunoprecipitation and FRET analysis indicates that OLT1177 inhibits inflammasome oligomerization by blocking NLRP3-ASC, and NLRP3-caspase-1 interaction, but may also directly target NLRP3 (as assessed by inhibition of recombinant NLRP3 ATPase activity by dapansutrile) .
SARS-CoV-2 and COVID-19: Dapansutrile's anti-inflammatory potential (via oral administration) is being investigated in COVID-19 patients with moderate symptoms.
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
|Compound class||Synthetic organic|
|International Nonproprietary Names|
|OLT-1177 | OLT1177|
|CAS Registry No.||54863-37-5 (source: WHO INN record)|
|GtoPdb PubChem SID||375973244|
|Search Google for chemical match using the InChIKey||LQFRYKBDZNPJSW-UHFFFAOYSA-N|
|Search Google for chemicals with the same backbone||LQFRYKBDZNPJSW|
|Search PubMed clinical trials||dapansutrile|
|Search PubMed titles||dapansutrile|
|Search PubMed titles/abstracts||dapansutrile|
|UniChem Compound Search for chemical match using the InChIKey||LQFRYKBDZNPJSW-UHFFFAOYSA-N|
|UniChem Connectivity Search for chemical match using the InChIKey||LQFRYKBDZNPJSW-UHFFFAOYSA-N|
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Cat. No. 6902