Compound class:
Synthetic organic
Comment: PHTPP-1304 is a novel protein degrader [1-2]. It binds to the estrogen receptor β via the ERβ antagonist PHTPP domain, and simultaneously to the autophagy receptor p62, to target the ERβ . This class of degrader is called an AUTOphagy-TArgeting Chimera, or AUTOTAC. AUTOTACs can be designed to target proteins of interest to autophagic membranes where they undergo lysosomal degradation, in a proteasome-independent manner.
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Classification ![]() |
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Compound class | Synthetic organic |
Ligand families/groups | PROTACs, molecular glues and other degraders |
IUPAC Name ![]() |
(2R)-1-[2-[2-[2-[4-[2-phenyl-5,7-bis(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-3-yl]phenoxy]ethoxy]ethoxy]ethylamino]-3-[4-phenylmethoxy-3-(3-phenylpropoxy)phenoxy]propan-2-ol |
Database Links ![]() |
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GtoPdb PubChem SID | 472319266 |
PubChem CID | 153397130 |
Search Google for chemical match using the InChIKey | RFLBGKJLIDOOAA-RRHRGVEJSA-N |
Search Google for chemicals with the same backbone | RFLBGKJLIDOOAA |
UniChem Compound Search for chemical match using the InChIKey | RFLBGKJLIDOOAA-RRHRGVEJSA-N |
UniChem Connectivity Search for chemical match using the InChIKey | RFLBGKJLIDOOAA-RRHRGVEJSA-N |