fascaplysin [Ligand Id: 5969] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL602937 (Fascaplysin) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Acetylcholinesterase in Electrophorus electricus (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4078] [UniProtKB: O42275] | ||||||||
| ChEMBL | Non-competitive inhibition of Electrophorus electricus AChE using acetylthiocholine iodide as substrate by Lineweaver-Burk reciprocal plot analysis | B | 5.64 | pKi | 2280 | nM | Ki | Medchemcomm (2012) 3: 1098-1103 |
| ChEMBL | Inhibition of Electrophorus electricus AChE using acetylthiocholine iodide as substrate after 30 mins by Ellman's method | B | 5.83 | pIC50 | 1490 | nM | IC50 | Medchemcomm (2012) 3: 1098-1103 |
| acetylcholinesterase (Yt blood group)/Acetylcholinesterase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL220] [GtoPdb: 2465] [UniProtKB: P22303] | ||||||||
| ChEMBL | Inhibition of AChE (unknown origin) using acetylthiocholine iodide as substrate incubated for 20 mins followed by substrate addition by Ellman's method | B | 5.82 | pIC50 | 1500 | nM | IC50 | J Med Chem (2021) 64: 1392-1422 [PMID:33528252] |
| butyrylcholinesterase/Butyrylcholinesterase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1914] [GtoPdb: 2471] [UniProtKB: P06276] | ||||||||
| ChEMBL | Inhibition of BuChE (unknown origin) using acetylthiocholine iodide as substrate incubated for 20 mins followed by substrate addition by Ellman's method | B | 4.05 | pIC50 | 90000 | nM | IC50 | J Med Chem (2021) 64: 1392-1422 [PMID:33528252] |
| cyclin dependent kinase 4/CDK4/Cyclin D3 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL3038472] [GtoPdb: 1976] [UniProtKB: P11802, P30281] | ||||||||
| ChEMBL | Inhibition of CDK4/cyclin-D3 (unknown origin) | B | 4 | pIC50 | >100000 | nM | IC50 | Medchemcomm (2012) 3: 1098-1103 |
| GtoPdb | CDK4/cyclin D1 complex | - | 6.46 | pIC50 | 350 | nM | IC50 | Biochem Biophys Res Commun (2000) 275: 877-84 [PMID:10973815] |
| cyclin dependent kinase 6/CDK6/cyclin D1 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2111455] [GtoPdb: 1978] [UniProtKB: P24385, Q00534] | ||||||||
| ChEMBL | Inhibition of CDK6/cyclin-D1 (unknown origin) | B | 5.47 | pIC50 | 3400 | nM | IC50 | Medchemcomm (2012) 3: 1098-1103 |
| cyclin dependent kinase 6/CDK6/cyclin D2 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL3301386] [GtoPdb: 1978] [UniProtKB: P30279, Q00534] | ||||||||
| ChEMBL | Inhibition of CDK6/cyclin-D2 (unknown origin) | B | 4.3 | pIC50 | >50000 | nM | IC50 | Medchemcomm (2012) 3: 1098-1103 |
| Cholinesterase in Equus caballus (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5763] [UniProtKB: P81908] | ||||||||
| ChEMBL | Non-competitive inhibition of equine serum BuChE using S-butyrylthiocholine iodide as substrate by Lineweaver-Burk reciprocal plot analysis | B | 4.31 | pKi | 48490 | nM | Ki | Medchemcomm (2012) 3: 1098-1103 |
| ChEMBL | Inhibition of equine serum BuChE using S-butyrylthiocholine iodide as substrate after 30 mins by Ellman's method | B | 4.04 | pIC50 | 90470 | nM | IC50 | Medchemcomm (2012) 3: 1098-1103 |
| cyclin dependent kinase 1/Cyclin-dependent kinase 1/cyclin B1 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL1907602] [GtoPdb: 1961] [UniProtKB: P06493, P14635] | ||||||||
| ChEMBL | Inhibition of CDK1/cyclin-B (unknown origin) | B | 4 | pIC50 | >100000 | nM | IC50 | Medchemcomm (2012) 3: 1098-1103 |
| cyclin dependent kinase 2/Cyclin-dependent kinase 2/cyclin E1 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL1907605] [GtoPdb: 1973] [UniProtKB: P24864, P24941] | ||||||||
| ChEMBL | Inhibition of CDK2/cyclin-E (unknown origin) | B | 4.3 | pIC50 | >50000 | nM | IC50 | Medchemcomm (2012) 3: 1098-1103 |
| cyclin dependent kinase 4/Cyclin-dependent kinase 4/cyclin D1 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL1907601] [GtoPdb: 1976] [UniProtKB: P11802, P24385] | ||||||||
| ChEMBL | Inhibition of CDK4/cyclin-D1 (unknown origin) | B | 6.46 | pIC50 | 350 | nM | IC50 | Medchemcomm (2012) 3: 1098-1103 |
| GtoPdb | CDK4/cyclin D1 complex | - | 6.46 | pIC50 | 350 | nM | IC50 | Biochem Biophys Res Commun (2000) 275: 877-84 [PMID:10973815] |
| cyclin dependent kinase 4/Cyclin-dependent kinase 4/cyclin D2 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL3301385] [GtoPdb: 1976] [UniProtKB: P11802, P30279] | ||||||||
| ChEMBL | Inhibition of CDK4/cyclin-D2 (unknown origin) | B | 4 | pIC50 | >100000 | nM | IC50 | Medchemcomm (2012) 3: 1098-1103 |
| GtoPdb | CDK4/cyclin D1 complex | - | 6.46 | pIC50 | 350 | nM | IC50 | Biochem Biophys Res Commun (2000) 275: 877-84 [PMID:10973815] |
| cyclin dependent kinase 5/Cyclin-dependent kinase 5/CDK5 activator 1 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL1907600] [GtoPdb: 1977] [UniProtKB: Q00535, Q15078] | ||||||||
| ChEMBL | Inhibition of CDK5/p-35 (unknown origin) | B | 4.7 | pIC50 | 20000 | nM | IC50 | Medchemcomm (2012) 3: 1098-1103 |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
