fascaplysin [Ligand Id: 5969] activity data from GtoPdb and ChEMBL

Click here for a description of the charts and data table

Please tell us if you are using this feature and what you think!

ChEMBL ligand: CHEMBL602937 (Fascaplysin)
  • Acetylcholinesterase in Electrophorus electricus [ChEMBL: CHEMBL4078] [UniProtKB: O42275]
  • This target only has 1 pki data point
  • 5.64
1 CHEMBL602937_lig_chart_1 Acetylcholinesterase Electrophorus electricus
There should be some charts here, you may need to enable JavaScript!
  • cyclin dependent kinase 4/CDK4/Cyclin D3 in Human [ChEMBL: CHEMBL3038472] [GtoPdb: 1976] [UniProtKB: P11802P30281]
  • This target only has 0 pki data point
  • 0
2 CHEMBL602937_lig_chart_2 CDK4/Cyclin D3 Human
There should be some charts here, you may need to enable JavaScript!
  • cyclin dependent kinase 6/CDK6/cyclin D1 in Human [ChEMBL: CHEMBL2111455] [GtoPdb: 1978] [UniProtKB: P24385Q00534]
  • This target only has 0 pki data point
  • 0
3 CHEMBL602937_lig_chart_3 CDK6/cyclin D1 Human
There should be some charts here, you may need to enable JavaScript!
  • cyclin dependent kinase 6/CDK6/cyclin D2 in Human [ChEMBL: CHEMBL3301386] [GtoPdb: 1978] [UniProtKB: P30279Q00534]
  • This target only has 0 pki data point
  • 0
4 CHEMBL602937_lig_chart_4 CDK6/cyclin D2 Human
There should be some charts here, you may need to enable JavaScript!
  • Cholinesterase in Equus caballus [ChEMBL: CHEMBL5763] [UniProtKB: P81908]
  • This target only has 1 pki data point
  • 4.31
5 CHEMBL602937_lig_chart_5 Cholinesterase Equus caballus
There should be some charts here, you may need to enable JavaScript!
  • cyclin dependent kinase 1/Cyclin-dependent kinase 1/cyclin B1 in Human [ChEMBL: CHEMBL1907602] [GtoPdb: 1961] [UniProtKB: P06493P14635]
  • This target only has 0 pki data point
  • 0
6 CHEMBL602937_lig_chart_6 Cyclin-dependent kinase 1/cyclin B1 Human
There should be some charts here, you may need to enable JavaScript!
  • cyclin dependent kinase 2/Cyclin-dependent kinase 2/cyclin E1 in Human [ChEMBL: CHEMBL1907605] [GtoPdb: 1973] [UniProtKB: P24864P24941]
  • This target only has 0 pki data point
  • 0
7 CHEMBL602937_lig_chart_7 Cyclin-dependent kinase 2/cyclin E1 Human
There should be some charts here, you may need to enable JavaScript!
  • cyclin dependent kinase 4/Cyclin-dependent kinase 4/cyclin D1 in Human [ChEMBL: CHEMBL1907601] [GtoPdb: 1976] [UniProtKB: P11802P24385]
  • This target only has 0 pki data point
  • 0
8 CHEMBL602937_lig_chart_8 Cyclin-dependent kinase 4/cyclin D1 Human
There should be some charts here, you may need to enable JavaScript!
  • cyclin dependent kinase 4/Cyclin-dependent kinase 4/cyclin D2 in Human [ChEMBL: CHEMBL3301385] [GtoPdb: 1976] [UniProtKB: P11802P30279]
  • This target only has 0 pki data point
  • 0
9 CHEMBL602937_lig_chart_9 Cyclin-dependent kinase 4/cyclin D2 Human
There should be some charts here, you may need to enable JavaScript!
  • cyclin dependent kinase 5/Cyclin-dependent kinase 5/CDK5 activator 1 in Human [ChEMBL: CHEMBL1907600] [GtoPdb: 1977] [UniProtKB: Q00535Q15078]
  • This target only has 0 pki data point
  • 0
10 CHEMBL602937_lig_chart_10 Cyclin-dependent kinase 5/CDK5 activator 1 Human
There should be some charts here, you may need to enable JavaScript!
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Acetylcholinesterase in Electrophorus electricus (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4078] [UniProtKB: O42275]
ChEMBL Non-competitive inhibition of Electrophorus electricus AChE using acetylthiocholine iodide as substrate by Lineweaver-Burk reciprocal plot analysis B 5.64 pKi 2280 nM Ki MedChemComm (2012) 3: 1098-1103
ChEMBL Inhibition of Electrophorus electricus AChE using acetylthiocholine iodide as substrate after 30 mins by Ellman's method B 5.83 pIC50 1490 nM IC50 MedChemComm (2012) 3: 1098-1103
cyclin dependent kinase 4/CDK4/Cyclin D3 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL3038472] [GtoPdb: 1976] [UniProtKB: P11802P30281]
ChEMBL Inhibition of CDK4/cyclin-D3 (unknown origin) B 4 pIC50 >100000 nM IC50 MedChemComm (2012) 3: 1098-1103
GtoPdb CDK4/cyclin D1 complex - 6.46 pIC50 350 nM IC50 Biochem Biophys Res Commun (2000) 275: 877-84 [PMID:10973815]
cyclin dependent kinase 6/CDK6/cyclin D1 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2111455] [GtoPdb: 1978] [UniProtKB: P24385Q00534]
ChEMBL Inhibition of CDK6/cyclin-D1 (unknown origin) B 5.47 pIC50 3400 nM IC50 MedChemComm (2012) 3: 1098-1103
cyclin dependent kinase 6/CDK6/cyclin D2 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL3301386] [GtoPdb: 1978] [UniProtKB: P30279Q00534]
ChEMBL Inhibition of CDK6/cyclin-D2 (unknown origin) B 4.3 pIC50 >50000 nM IC50 MedChemComm (2012) 3: 1098-1103
Cholinesterase in Equus caballus (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5763] [UniProtKB: P81908]
ChEMBL Non-competitive inhibition of equine serum BuChE using S-butyrylthiocholine iodide as substrate by Lineweaver-Burk reciprocal plot analysis B 4.31 pKi 48490 nM Ki MedChemComm (2012) 3: 1098-1103
ChEMBL Inhibition of equine serum BuChE using S-butyrylthiocholine iodide as substrate after 30 mins by Ellman's method B 4.04 pIC50 90470 nM IC50 MedChemComm (2012) 3: 1098-1103
cyclin dependent kinase 1/Cyclin-dependent kinase 1/cyclin B1 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL1907602] [GtoPdb: 1961] [UniProtKB: P06493P14635]
ChEMBL Inhibition of CDK1/cyclin-B (unknown origin) B 4 pIC50 >100000 nM IC50 MedChemComm (2012) 3: 1098-1103
cyclin dependent kinase 2/Cyclin-dependent kinase 2/cyclin E1 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL1907605] [GtoPdb: 1973] [UniProtKB: P24864P24941]
ChEMBL Inhibition of CDK2/cyclin-E (unknown origin) B 4.3 pIC50 >50000 nM IC50 MedChemComm (2012) 3: 1098-1103
cyclin dependent kinase 4/Cyclin-dependent kinase 4/cyclin D1 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL1907601] [GtoPdb: 1976] [UniProtKB: P11802P24385]
ChEMBL Inhibition of CDK4/cyclin-D1 (unknown origin) B 6.46 pIC50 350 nM IC50 MedChemComm (2012) 3: 1098-1103
GtoPdb CDK4/cyclin D1 complex - 6.46 pIC50 350 nM IC50 Biochem Biophys Res Commun (2000) 275: 877-84 [PMID:10973815]
cyclin dependent kinase 4/Cyclin-dependent kinase 4/cyclin D2 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL3301385] [GtoPdb: 1976] [UniProtKB: P11802P30279]
ChEMBL Inhibition of CDK4/cyclin-D2 (unknown origin) B 4 pIC50 >100000 nM IC50 MedChemComm (2012) 3: 1098-1103
GtoPdb CDK4/cyclin D1 complex - 6.46 pIC50 350 nM IC50 Biochem Biophys Res Commun (2000) 275: 877-84 [PMID:10973815]
cyclin dependent kinase 5/Cyclin-dependent kinase 5/CDK5 activator 1 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL1907600] [GtoPdb: 1977] [UniProtKB: Q00535Q15078]
ChEMBL Inhibition of CDK5/p-35 (unknown origin) B 4.7 pIC50 20000 nM IC50 MedChemComm (2012) 3: 1098-1103

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]