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ChEMBL ligand: CHEMBL494502 (AC-264613) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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PAR2/Proteinase-activated receptor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5963] [GtoPdb: 348] [UniProtKB: P55085] | ||||||||
ChEMBL | Agonist activity at human PAR2 expressed in HEK293T cells assessed as effect on intracellular calcium mobilization by R-SAT assay | F | 5 | pEC50 | >10000 | nM | EC50 | J. Med. Chem. (2008) 51: 5490-5493 [PMID:18720984] |
GtoPdb | - | - | 7.5 | pEC50 | 31.6 | nM | EC50 | J Med Chem (2008) 51: 5490-3 [PMID:18720984] |
ChEMBL | Agonist activity at human PAR2 expressed in HEK293T cells assessed as effect on intracellular calcium mobilization by R-SAT assay | F | 7.5 | pEC50 | 31.62 | nM | EC50 | J. Med. Chem. (2008) 51: 5490-5493 [PMID:18720984] |
ChEMBL | Agonist activity at human PAR2 expressed in HEK293T cells assessed as effect on intracellular calcium mobilization by R-SAT assay | F | 7.5 | pEC50 | 31.62 | nM | EC50 | J. Med. Chem. (2008) 51: 5490-5493 [PMID:18720984] |
ChEMBL | Agonist activity at human PAR2 expressed in HEK293T cells assessed as increase in intracellular calcium level by bioluminescence assay | F | 7.52 | pEC50 | 30 | nM | EC50 | J. Med. Chem. (2013) 56: 7477-7497 [PMID:23895492] |
ChEMBL | Agonist activity at human PAR2 expressed in HEK293T cells assessed as stimulation of phosphatidylinositol hydrolysis after 45 mins by scintillation counting analysis | F | 7.52 | pEC50 | 30 | nM | EC50 | J. Med. Chem. (2013) 56: 7477-7497 [PMID:23895492] |
ChEMBL | Agonist activity at human PAR2 expressed in HEK293T cells assessed as stimulation of cell proliferation after 5 days by beta-galactosidase assay | B | 7.52 | pEC50 | 30 | nM | EC50 | J. Med. Chem. (2013) 56: 7477-7497 [PMID:23895492] |
ChEMBL data shown on this page come from version 31:
Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]