Synonyms: Duodopa® | Lodosyn® | MK 486 [4]
carbidopa is an approved drug (FDA (1977))
Compound class:
Synthetic organic
Comment: Carbidopa was originally approved by the FDA in combination with levodopa in 1975. It is an inhibitor of L-Aromatic amino-acid decarboxylase (a.k.a. L-Dopa decarboxylase) [1,4] that decreases the peripheral decarboxylation of levodopa to dopamine. The competitive or noncompetitive nature of carbidopa's interaction with L-Dopa decarboxylase is complex. Two published papers that discuss the kinetics of the inhibitor/enzyme interaction are [4] and [1], and from analysis of these it would appear that due to the slow dissociation of carbidopa from L-Dopa decarboxylase, once the enzyme/inhibitor complex has formed substrate is unable to displace the inhibitor. Carbidopa is described as a competitive inhibitor in these articles [2-3].
View more information in the IUPHAR Pharmacology Education Project: carbidopa |
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Classification | |
Compound class | Synthetic organic |
Approved drug? | Yes (FDA (1977)) |
WHO Essential Medicine | WHO Essential Medicines List (EML) (23rd List, 2023). Access PDF version. Click to view more information about the WHO Model Lists of Essential Medicines. |
IUPAC Name |
(2S)-3-(3,4-dihydroxyphenyl)-2-hydrazinyl-2-methylpropanoic acid |
International Nonproprietary Names | |
INN number | INN |
3258 | carbidopa |
Synonyms | |
Duodopa® | Lodosyn® | MK 486 [4] |
Database Links | |
CAS Registry No. | 28860-95-9 |
ChEBI | CHEBI:39585 |
ChEMBL Ligand | CHEMBL1201236 |
DrugBank Ligand | DB00190 |
DrugCentral Ligand | 496 |
GtoPdb PubChem SID | 178101851 |
PubChem CID | 34359 |
RCSB PDB Ligand | 142 |
Search Google for chemical match using the InChIKey | TZFNLOMSOLWIDK-JTQLQIEISA-N |
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Wikipedia | Carbidopa |