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ChEMBL ligand: CHEMBL1161861 (Adenosine 2',5'-Diphosphate) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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Ketopantoate reductase in Escherichia coli K-12 (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4855] [UniProtKB: P0A9J4] | ||||||||
ChEMBL | Binding affinity to Escherichia coli KPR | B | 4 | pKd | 100000 | nM | Kd | J. Med. Chem. (2006) 49: 4992-5000 [PMID:16884311] |
P2Y purinoceptor 1 in Turkey (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5720] [UniProtKB: P49652] | ||||||||
ChEMBL | Antagonist activity at P2Y1 receptor measured as capacity to inhibit 50% of phospholipase C stimulation elicited by 10 nM 2-MeSATP | F | 5.07 | pIC50 | 8460 | nM | IC50 | J. Med. Chem. (1998) 41: 183-190 [PMID:9457242] |
ChEMBL | Agonist activity at P2Y1 receptor measured as capacity to stimulate 50% phospholipase C in turkey erythrocyte membranes | F | 5.86 | pEC50 | 1370 | nM | EC50 | J. Med. Chem. (1998) 41: 183-190 [PMID:9457242] |
P2Y1 receptor in Human [GtoPdb: 323] [UniProtKB: P47900] | ||||||||
GtoPdb | - | - | 5.8 | pEC50 | - | - | - | Mol Pharmacol (1996) 50: 1323-9 [PMID:8913364] |
ChEMBL data shown on this page come from version 31:
Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]