A2P5P [Ligand Id: 1717] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1161861 (Adenosine 2',5'-Diphosphate)
  • Ketopantoate reductase in Escherichia coli [ChEMBL: CHEMBL4855] [UniProtKB: P0A9J4]
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  • P2Y1 receptor in Human [GtoPdb: 323] [UniProtKB: P47900]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Ketopantoate reductase in Escherichia coli (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4855] [UniProtKB: P0A9J4]
ChEMBL Binding affinity to Escherichia coli KPR B 4 pKd 100000 nM Kd J Med Chem (2006) 49: 4992-5000 [PMID:16884311]
P2Y purinoceptor 1 in Turkey (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5720] [UniProtKB: P49652]
ChEMBL Antagonist activity at P2Y1 receptor measured as capacity to inhibit 50% of phospholipase C stimulation elicited by 10 nM 2-MeSATP F 5.07 pIC50 8460 nM IC50 J Med Chem (1998) 41: 183-190 [PMID:9457242]
ChEMBL Agonist activity at P2Y1 receptor measured as capacity to stimulate 50% phospholipase C in turkey erythrocyte membranes F 5.86 pEC50 1370 nM EC50 J Med Chem (1998) 41: 183-190 [PMID:9457242]
P2Y1 receptor in Human [GtoPdb: 323] [UniProtKB: P47900]
GtoPdb - - 5.8 pEC50 - - - Mol Pharmacol (1996) 50: 1323-9 [PMID:8913364]

ChEMBL data shown on this page come from version 32:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]