ChEMBL ligand: CHEMBL362558 (Ly 2090314, Ly-2090314, LY-2090314, LY2090314)
protein kinase, cAMP-dependent, catalytic, beta subunit/cAMP-dependent protein kinase beta-1 catalytic subunit in Human [ChEMBL: CHEMBL2918] [GtoPdb: 1477] [UniProtKB: P22694] There should be some charts here, you may need to enable JavaScript!
cyclin dependent kinase 2/Cyclin-dependent kinase 2 in Human [ChEMBL: CHEMBL301] [GtoPdb: 1973] [UniProtKB: P24941] There should be some charts here, you may need to enable JavaScript!
cyclin dependent kinase 4/Cyclin-dependent kinase 4 in Human [ChEMBL: CHEMBL331] [GtoPdb: 1976] [UniProtKB: P11802] There should be some charts here, you may need to enable JavaScript!
glycogen synthase kinase 3 alpha/Glycogen synthase kinase-3 alpha in Human [ChEMBL: CHEMBL2850] [GtoPdb: 2029] [UniProtKB: P49840] There should be some charts here, you may need to enable JavaScript!
glycogen synthase kinase 3 beta/Glycogen synthase kinase-3 beta in Human [ChEMBL: CHEMBL262] [GtoPdb: 2030] [UniProtKB: P49841] There should be some charts here, you may need to enable JavaScript!
ZAK sterile alpha motif and leucine zipper containing kinase AZK/Mixed lineage kinase 7 in Human [ChEMBL: CHEMBL3886] [GtoPdb: 2289] [UniProtKB: Q9NYL2] There should be some charts here, you may need to enable JavaScript!
protein kinase C beta/Protein kinase C beta in Human [ChEMBL: CHEMBL3045] [GtoPdb: 1483] [UniProtKB: P05771] There should be some charts here, you may need to enable JavaScript!
pyruvate dehydrogenase kinase 1/Pyruvate dehydrogenase kinase isoform 1 in Human [ChEMBL: CHEMBL4766] [GtoPdb: 2915] [UniProtKB: Q15118] There should be some charts here, you may need to enable JavaScript!
AKT serine/threonine kinase 1/Serine/threonine-protein kinase AKT in Human [ChEMBL: CHEMBL4282] [GtoPdb: 1479] [UniProtKB: P31749] There should be some charts here, you may need to enable JavaScript!
transforming growth factor beta receptor 2/TGF-beta receptor type II in Human [ChEMBL: CHEMBL4267] [GtoPdb: 1795] [UniProtKB: P37173] There should be some charts here, you may need to enable JavaScript!
kinase insert domain receptor/Vascular endothelial growth factor receptor 2 in Human [ChEMBL: CHEMBL279] [GtoPdb: 1813] [UniProtKB: P35968] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
protein kinase, cAMP-dependent, catalytic, beta subunit/cAMP-dependent protein kinase beta-1 catalytic subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2918] [GtoPdb: 1477] [UniProtKB: P22694]
ChEMBL	Inhibition of human Protein kinase A beta	B	4.7	pIC50	>20000	nM	IC50	J Med Chem (2004) 47: 3934-3937 [PMID:15267232]
cyclin dependent kinase 2/Cyclin-dependent kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL301] [GtoPdb: 1973] [UniProtKB: P24941]
ChEMBL	Inhibition of human Cyclin-dependent kinase 2	B	5.55	pIC50	2800	nM	IC50	J Med Chem (2004) 47: 3934-3937 [PMID:15267232]
cyclin dependent kinase 4/Cyclin-dependent kinase 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL331] [GtoPdb: 1976] [UniProtKB: P11802]
ChEMBL	Inhibition of human Cyclin-dependent kinase 4	B	5.74	pIC50	1800	nM	IC50	J Med Chem (2004) 47: 3934-3937 [PMID:15267232]
glycogen synthase kinase 3 alpha/Glycogen synthase kinase-3 alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2850] [GtoPdb: 2029] [UniProtKB: P49840]
ChEMBL	Inhibition of GSK3alpha (unknown origin)	B	8.82	pIC50	1.5	nM	IC50	Drug Metab Dispos (2013) 41: 714-726 [PMID:23305709]
ChEMBL	Inhibition of human GSK-3alpha using YRRAAVPPSPSLSRHSSPHQ(pS)EDEEE as substrate measured in presence of [gamma-33P]ATP by radiometric assay	B	8.82	pIC50	1.5	nM	IC50	Eur J Med Chem (2019) 171: 221-234 [PMID:30925338]
ChEMBL	Inhibition of human GSK-3alpha S449A mutant (2 to end residues) using phospho GS2 peptide as substrate after 40 mins in presence of [gamma-33ATP] by scintillation counting method	B	8.99	pIC50	1.02	nM	IC50	Eur J Med Chem (2019) 171: 221-234 [PMID:30925338]
glycogen synthase kinase 3 beta/Glycogen synthase kinase-3 beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL262] [GtoPdb: 2030] [UniProtKB: P49841]
ChEMBL	Inhibition of human Glycogen synthase kinase-3 beta	B	8.96	pIC50	1.1	nM	IC50	J Med Chem (2004) 47: 3934-3937 [PMID:15267232]
ChEMBL	Inhibition of human GSK3-beta	B	8.96	pIC50	1.1	nM	IC50	Eur J Med Chem (2009) 44: 2361-2371 [PMID:18929433]
GtoPdb	Inhibition of GSK-3β-mediated phosphoryaltion of phosph0-CREB	-	8.96	pIC50	1.1	nM	IC50	J Med Chem (2004) 47: 3934-7 [PMID:15267232]
ChEMBL	Inhibition of GSK3beta (unknown origin)	B	9.05	pIC50	0.9	nM	IC50	Drug Metab Dispos (2013) 41: 714-726 [PMID:23305709]
ChEMBL	Inhibition of Glycogen synthase kinase-3 beta dependent Tau protein serine-396 phosphorylation in human SY5Y cells	F	9.15	pIC50	0.7	nM	IC50	J Med Chem (2004) 47: 3934-3937 [PMID:15267232]
ZAK sterile alpha motif and leucine zipper containing kinase AZK/Mixed lineage kinase 7 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3886] [GtoPdb: 2289] [UniProtKB: Q9NYL2]
ChEMBL	Inhibition of human MLK7	B	4.7	pIC50	>20000	nM	IC50	J Med Chem (2004) 47: 3934-3937 [PMID:15267232]
protein kinase C beta/Protein kinase C beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3045] [GtoPdb: 1483] [UniProtKB: P05771]
ChEMBL	Inhibition of human Protein kinase C beta 2	B	6.38	pIC50	420	nM	IC50	J Med Chem (2004) 47: 3934-3937 [PMID:15267232]
pyruvate dehydrogenase kinase 1/Pyruvate dehydrogenase kinase isoform 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4766] [GtoPdb: 2915] [UniProtKB: Q15118]
ChEMBL	Inhibition of human PDK-1	B	5.21	pIC50	6200	nM	IC50	J Med Chem (2004) 47: 3934-3937 [PMID:15267232]
AKT serine/threonine kinase 1/Serine/threonine-protein kinase AKT in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4282] [GtoPdb: 1479] [UniProtKB: P31749]
ChEMBL	Inhibition of human Akt1	B	4.7	pIC50	>20000	nM	IC50	J Med Chem (2004) 47: 3934-3937 [PMID:15267232]
transforming growth factor beta receptor 2/TGF-beta receptor type II in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4267] [GtoPdb: 1795] [UniProtKB: P37173]
ChEMBL	Inhibition of human TGF-beta type II receptor	B	5.92	pIC50	>1200	nM	IC50	J Med Chem (2004) 47: 3934-3937 [PMID:15267232]
kinase insert domain receptor/Vascular endothelial growth factor receptor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL279] [GtoPdb: 1813] [UniProtKB: P35968]
ChEMBL	Inhibition of human Vascular endothelial growth factor receptor 2	B	4.7	pIC50	>20000	nM	IC50	J Med Chem (2004) 47: 3934-3937 [PMID:15267232]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]