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ChEMBL ligand: CHEMBL362558 (Ly 2090314, Ly-2090314, LY-2090314, LY2090314) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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protein kinase, cAMP-dependent, catalytic, beta subunit/cAMP-dependent protein kinase beta-1 catalytic subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2918] [GtoPdb: 1477] [UniProtKB: P22694] | ||||||||
ChEMBL | Inhibition of human Protein kinase A beta | B | 4.7 | pIC50 | >20000 | nM | IC50 | J Med Chem (2004) 47: 3934-3937 [PMID:15267232] |
cyclin dependent kinase 2/Cyclin-dependent kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL301] [GtoPdb: 1973] [UniProtKB: P24941] | ||||||||
ChEMBL | Inhibition of human Cyclin-dependent kinase 2 | B | 5.55 | pIC50 | 2800 | nM | IC50 | J Med Chem (2004) 47: 3934-3937 [PMID:15267232] |
cyclin dependent kinase 4/Cyclin-dependent kinase 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL331] [GtoPdb: 1976] [UniProtKB: P11802] | ||||||||
ChEMBL | Inhibition of human Cyclin-dependent kinase 4 | B | 5.74 | pIC50 | 1800 | nM | IC50 | J Med Chem (2004) 47: 3934-3937 [PMID:15267232] |
glycogen synthase kinase 3 alpha/Glycogen synthase kinase-3 alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2850] [GtoPdb: 2029] [UniProtKB: P49840] | ||||||||
ChEMBL | Inhibition of GSK3alpha (unknown origin) | B | 8.82 | pIC50 | 1.5 | nM | IC50 | Drug Metab Dispos (2013) 41: 714-726 [PMID:23305709] |
ChEMBL | Inhibition of human GSK-3alpha using YRRAAVPPSPSLSRHSSPHQ(pS)EDEEE as substrate measured in presence of [gamma-33P]ATP by radiometric assay | B | 8.82 | pIC50 | 1.5 | nM | IC50 | Eur J Med Chem (2019) 171: 221-234 [PMID:30925338] |
ChEMBL | Inhibition of human GSK-3alpha S449A mutant (2 to end residues) using phospho GS2 peptide as substrate after 40 mins in presence of [gamma-33ATP] by scintillation counting method | B | 8.99 | pIC50 | 1.02 | nM | IC50 | Eur J Med Chem (2019) 171: 221-234 [PMID:30925338] |
glycogen synthase kinase 3 beta/Glycogen synthase kinase-3 beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL262] [GtoPdb: 2030] [UniProtKB: P49841] | ||||||||
ChEMBL | Inhibition of human Glycogen synthase kinase-3 beta | B | 8.96 | pIC50 | 1.1 | nM | IC50 | J Med Chem (2004) 47: 3934-3937 [PMID:15267232] |
ChEMBL | Inhibition of human GSK3-beta | B | 8.96 | pIC50 | 1.1 | nM | IC50 | Eur J Med Chem (2009) 44: 2361-2371 [PMID:18929433] |
GtoPdb | Inhibition of GSK-3β-mediated phosphoryaltion of phosph0-CREB | - | 8.96 | pIC50 | 1.1 | nM | IC50 | J Med Chem (2004) 47: 3934-7 [PMID:15267232] |
ChEMBL | Inhibition of GSK3beta (unknown origin) | B | 9.05 | pIC50 | 0.9 | nM | IC50 | Drug Metab Dispos (2013) 41: 714-726 [PMID:23305709] |
ChEMBL | Inhibition of Glycogen synthase kinase-3 beta dependent Tau protein serine-396 phosphorylation in human SY5Y cells | F | 9.15 | pIC50 | 0.7 | nM | IC50 | J Med Chem (2004) 47: 3934-3937 [PMID:15267232] |
ZAK sterile alpha motif and leucine zipper containing kinase AZK/Mixed lineage kinase 7 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3886] [GtoPdb: 2289] [UniProtKB: Q9NYL2] | ||||||||
ChEMBL | Inhibition of human MLK7 | B | 4.7 | pIC50 | >20000 | nM | IC50 | J Med Chem (2004) 47: 3934-3937 [PMID:15267232] |
protein kinase C beta/Protein kinase C beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3045] [GtoPdb: 1483] [UniProtKB: P05771] | ||||||||
ChEMBL | Inhibition of human Protein kinase C beta 2 | B | 6.38 | pIC50 | 420 | nM | IC50 | J Med Chem (2004) 47: 3934-3937 [PMID:15267232] |
pyruvate dehydrogenase kinase 1/Pyruvate dehydrogenase kinase isoform 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4766] [GtoPdb: 2915] [UniProtKB: Q15118] | ||||||||
ChEMBL | Inhibition of human PDK-1 | B | 5.21 | pIC50 | 6200 | nM | IC50 | J Med Chem (2004) 47: 3934-3937 [PMID:15267232] |
AKT serine/threonine kinase 1/Serine/threonine-protein kinase AKT in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4282] [GtoPdb: 1479] [UniProtKB: P31749] | ||||||||
ChEMBL | Inhibition of human Akt1 | B | 4.7 | pIC50 | >20000 | nM | IC50 | J Med Chem (2004) 47: 3934-3937 [PMID:15267232] |
transforming growth factor beta receptor 2/TGF-beta receptor type II in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4267] [GtoPdb: 1795] [UniProtKB: P37173] | ||||||||
ChEMBL | Inhibition of human TGF-beta type II receptor | B | 5.92 | pIC50 | >1200 | nM | IC50 | J Med Chem (2004) 47: 3934-3937 [PMID:15267232] |
kinase insert domain receptor/Vascular endothelial growth factor receptor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL279] [GtoPdb: 1813] [UniProtKB: P35968] | ||||||||
ChEMBL | Inhibition of human Vascular endothelial growth factor receptor 2 | B | 4.7 | pIC50 | >20000 | nM | IC50 | J Med Chem (2004) 47: 3934-3937 [PMID:15267232] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]