HS-142-1   Click here for help

GtoPdb Ligand ID: 4952

Synonyms: HS142-1
Comment: HS-142-1, a novel nonpeptide (polysaccharide) atrial natriuretic peptide (ANP) antagonist which specifically inhibits natriuretic peptide-induced vasorelaxation through the blockade of guanylyl cyclase-linked natriuretic peptide receptors [1]. It was purified from the fermentation broth of Aureobasidium pullulans var. melanigenum [3]. The compound consists of glucose and caproyl subunits. Hexaosyl fragment O-(3-O-caproyl-beta-D-glucopyranosyl)-(1-->6)-[O-(beta-D- glucopyranosyl)-(1-->6)-O-(3-O-caproyl-beta-D-glucopyranosyl)-(1--> 6)]2-D-glucopyranose, is among the major components of the molecule and ithis has been used as the basis for synthesising synthetic analogues of the polysaccharide.
Classification Click here for help
Compound class Natural product or derivative
Synonyms Click here for help
Database Links Click here for help
GtoPdb PubChem SID 178101650