L-lysine [Ligand Id: 724] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL8085 (Lysine)
  • glutathione-disulfide reductase/Glutathione reductase in Human [ChEMBL: CHEMBL2755] [GtoPdb: 2613] [UniProtKB: P00390]
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  • GPRC6 receptor in Human [GtoPdb: 55] [UniProtKB: Q5T6X5]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
glutathione-disulfide reductase/Glutathione reductase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2755] [GtoPdb: 2613] [UniProtKB: P00390]
ChEMBL Competitive inhibition of human erythrocyte Glutathione reductase using GSSG substrate by Lineweaver-Burk plot analysis B 4.26 pKi 54600 nM Ki Bioorg. Med. Chem. Lett. (2011) 21: 5398-5402 [PMID:21795044]
ChEMBL Inhibition of human erythrocyte Glutathione reductase B 4.21 pIC50 61200 nM IC50 Bioorg. Med. Chem. Lett. (2011) 21: 5398-5402 [PMID:21795044]
GPRC6 receptor in Human [GtoPdb: 55] [UniProtKB: Q5T6X5]
GtoPdb - - 3.8 pEC50 - - - Mol Pharmacol (2005) 67: 589-97 [PMID:15576628]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]