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Gene and Protein Information | ||||||
Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
Human | - | 522 | 8p12 | GSR | glutathione-disulfide reductase | |
Mouse | - | 500 | 8 20.69 cM | Gsr | glutathione reductase | |
Rat | - | 424 | 16q12.3 | Gsr | glutathione-disulfide reductase |
Previous and Unofficial Names |
glutathione reductase, mitochondrial | glutathione reductase |
Database Links | |
Alphafold | P00390 (Hs), P47791 (Mm), P70619 (Rn) |
BRENDA | 1.8.1.7 |
CATH/Gene3D | 3.50.50.60, 3.30.390.30 |
ChEMBL Target | CHEMBL2755 (Hs), CHEMBL2366476 (Mm), CHEMBL3286088 (Rn) |
DrugBank Target | P00390 (Hs) |
Ensembl Gene | ENSG00000104687 (Hs), ENSMUSG00000031584 (Mm), ENSRNOG00000014915 (Rn) |
Entrez Gene | 2936 (Hs), 14782 (Mm), 116686 (Rn) |
Human Protein Atlas | ENSG00000104687 (Hs) |
KEGG Enzyme | 1.8.1.7 |
KEGG Gene | hsa:2936 (Hs), mmu:14782 (Mm), rno:116686 (Rn) |
OMIM | 138300 (Hs) |
Orphanet | ORPHA122298 (Hs) |
Pharos | P00390 (Hs) |
RefSeq Nucleotide | NM_000637 (Hs), NM_010344 (Mm), NM_053906 (Rn) |
RefSeq Protein | NP_000628 (Hs), NP_034474 (Mm), NP_446358 (Rn) |
SynPHARM | 78934 (in complex with oxiglutatione) |
UniProtKB | P00390 (Hs), P47791 (Mm), P70619 (Rn) |
Wikipedia | GSR (Hs) |
Selected 3D Structures | |||||||||||
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Enzyme Reaction | ||||
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Download all structure-activity data for this target as a CSV file
Inhibitors | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Key to terms and symbols | View all chemical structures | Click column headers to sort | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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View species-specific inhibitor tables | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Inhibitor Comments | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Apart from the CHEMBL listing of oxiglutatione as an approved drug acting at glutathione reductase and one PubMed reference describing a its use in a single clinical case study [4], there is very little information available about this drug and its mechanism of action. |
Clinically-Relevant Mutations and Pathophysiology | ||||||||
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1. Bauer H, Fritz-Wolf K, Winzer A, Kühner S, Little S, Yardley V, Vezin H, Palfey B, Schirmer RH, Davioud-Charvet E. (2006) A fluoro analogue of the menadione derivative 6-[2'-(3'-methyl)-1',4'-naphthoquinolyl]hexanoic acid is a suicide substrate of glutathione reductase. Crystal structure of the alkylated human enzyme. J Am Chem Soc, 128 (33): 10784-94. [PMID:16910673]
2. Berkholz DS, Faber HR, Savvides SN, Karplus PA. (2008) Catalytic cycle of human glutathione reductase near 1 A resolution. J Mol Biol, 382 (2): 371-84. [PMID:18638483]
3. Liu X, Sturla SJ. (2009) Profiling patterns of glutathione reductase inhibition by the natural product illudin S and its acylfulvene analogues. Mol Biosyst, 5 (9): 1013-24. [PMID:19668867]
4. Nakatani Y, Nishimura A, Sugiyama K. (2013) Successful treatment of corneal wasp sting-induced panuveitis with vitrectomy. J Ophthalmic Inflamm Infect, 3 (1): 18. [PMID:23514564]
1.-.-.- Oxidoreductases: glutathione-disulfide reductase. Last modified on 13/08/2015. Accessed on 02/12/2024. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2613.