tebuquine [Ligand Id: 10392] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL339049 (CI-897, Tebuquine, WR-228,258, WR-228258) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364] | ||||||||
| ChEMBL | Antimicrobial activity against Plasmodium falciparum | F | 4.28 | pIC50 | 53000 | nM | IC50 | Bioorg Med Chem (2010) 18: 2225-2231 [PMID:20185316] |
| ChEMBL | In vitro inhibition of chloroquine-resistant Plasmodium falciparum K1 | F | 7.38 | pIC50 | 42.1 | nM | IC50 | J Med Chem (1997) 40: 437-448 [PMID:9046333] |
| ChEMBL | In vitro inhibition of chloroquine-sensitive Plasmodium falciparum HB3 | F | 7.62 | pIC50 | 24.2 | nM | IC50 | J Med Chem (1997) 40: 437-448 [PMID:9046333] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum K1 | F | 7.68 | pIC50 | 21 | nM | IC50 | Bioorg Med Chem Lett (1996) 6: 391-392 |
| ChEMBL | In vitro inhibition of chloroquine-resistant Plasmodium falciparum K1 | F | 7.68 | pIC50 | 20.8 | nM | IC50 | J Med Chem (1997) 40: 437-448 [PMID:9046333] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum 3D7 | F | 7.74 | pIC50 | 18 | nM | IC50 | Bioorg Med Chem Lett (1996) 6: 391-392 |
| ChEMBL | In vitro inhibition of chloroquine-sensitive Plasmodium falciparum HB3 | F | 9.05 | pIC50 | 0.9 | nM | IC50 | J Med Chem (1997) 40: 437-448 [PMID:9046333] |
| Plasmodium falciparum (isolate K1 / Thailand) in Plasmodium falciparum K1 (target type: ORGANISM) [ChEMBL: CHEMBL612856] | ||||||||
| ChEMBL | Antimalarial activity against chloroquine-resistant Plasmodium falciparum K1 after 48 hrs by [G-3H]hypoxanthine uptake | F | 7.89 | pIC50 | 13 | nM | IC50 | Eur J Med Chem (2008) 43: 2840-2852 [PMID:18395298] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
