ibuprofen [Ligand Id: 2713] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL521 (Proflex sr, IP-82, NSC-256857, Tab-profen, Children's advil-flavored, Fenpaed, Lobufen, Ibumetin, Inabrin, Ibuprin, Relcofen, U-18,573, Medipren, Phorpain max strgh, Co-op, Cap-profen, Nuprin, Paxofen, Ibucalm, Children's elixsure, Maxa-gesic, Ibuprofen, Novaprin, Inoven, Ibutime, Ibuprohm, Feverfen, Anadin ultra, Suspren, Children's motrin, Ibuleve, Cuprofen plus, Phorpain, Fenbid, Ibugel, Manorfen, Apsifen, Anadin period pain relief, Ibu-slo, Fenbid fte, Femafen, Profen, Junior strength advil, Lidifen, Pediatric advil, Arthrofen 600, Motrin ib, Motrin migraine pain, Infant's advil, Junifen, Ibumed, Brufen ret, Ibuspray, Children's advil, Ibufac, Pacifene, Orbifen, Ibu-tab, Nurofen for child, Midol, Advil liqui-gels, Advil migraine liqui-gels, Deep relief, Ibugel fte, Rufen, Aches-n-pain, Anadin liquifast, IB-100, Children's ibuprofen, RD 13621, Junior strength motrin, Anadin joint pain, Cuprofen for child, Apsifen-f, Ibular, Junior strength ibuprofen, Arthrofen 400, Lidifen-f, Proflex, Ibuderm, Rimafen, Isisfen, Nurofen back pain sr, Motrin, Ebufac, Nurofen recovery, Fleximex, Pedea, Arthrofen 200, Migrafen, Nurofen plus, Advil, Phensic, U-18573, Mandafen, Seclodin, Ibumousse, Nurofen sinus, Nurofen 400, Ibu-tab 200, M01AE01, Midol liquid gels, Nurofen solb, Caldolor, Codafen continus, Nurofen child, Phor pain)
  • AKR1C3/Aldo-keto-reductase family 1 member C3 in Human [ChEMBL: CHEMBL4681] [GtoPdb: 1382] [UniProtKB: P42330]
  • This target only has 0 pki data point
  • 0
1 CHEMBL521_lig_chart_1 Aldo-keto-reductase family 1 member C3 Human
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  • 5-LOX/Arachidonate 5-lipoxygenase in Human [ChEMBL: CHEMBL215] [GtoPdb: 1385] [UniProtKB: P09917]
  • 5-LOX/Arachidonate 5-lipoxygenase in Rat [ChEMBL: CHEMBL312] [GtoPdb: 1385] [UniProtKB: P12527]
  • This target only has 0 pki data point
  • 0
2 CHEMBL521_lig_chart_2 Arachidonate 5-lipoxygenase HumanRat
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  • COX-1 /Cyclooxygenase-1 in Human [ChEMBL: CHEMBL221] [GtoPdb: 1375] [UniProtKB: P23219]
  • Cyclooxygenase-1 in Bovine [ChEMBL: CHEMBL2860] [UniProtKB: O62664]
  • Cyclooxygenase-1 in Sheep [ChEMBL: CHEMBL2949] [UniProtKB: P05979]
  • This target only has 1 pki data point
  • 5.05
3 CHEMBL521_lig_chart_3 Cyclooxygenase-1 HumanBovineSheep
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4 CHEMBL521_lig_chart_4 Cyclooxygenase-2 HumanBovineSheepMouse
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  • Dehydrogenase/reductase SDR family member 9 in Rat [ChEMBL: CHEMBL1075220] [UniProtKB: Q8VD48]
  • This target only has 0 pki data point
  • 0
5 CHEMBL521_lig_chart_5 Dehydrogenase/reductase SDR family member 9 Rat
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  • epidermal growth factor receptor/Epidermal growth factor receptor erbB1 in Human [ChEMBL: CHEMBL203] [GtoPdb: 1797] [UniProtKB: P00533]
  • This target only has 0 pki data point
  • 0
6 CHEMBL521_lig_chart_6 Epidermal growth factor receptor erbB1 Human
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  • fatty acid binding protein 1/Fatty acid-binding protein, liver in Rat [ChEMBL: CHEMBL5738] [GtoPdb: 2531] [UniProtKB: P02692]
  • This target only has 1 pki data point
  • 4.32
7 CHEMBL521_lig_chart_7 Fatty acid-binding protein, liver Rat
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  • L-PGDS/Prostaglandin-H2 D-isomerase in Mouse [ChEMBL: CHEMBL4334] [GtoPdb: 1380] [UniProtKB: O09114]
  • This target only has 0 pki data point
  • 0
8 CHEMBL521_lig_chart_8 Prostaglandin-H2 D-isomerase Mouse
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  • Serum albumin in Bovine [ChEMBL: CHEMBL3728] [UniProtKB: P02769]
  • This target only has 0 pki data point
  • 0
9 CHEMBL521_lig_chart_9 Serum albumin Bovine
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  • OAT6/Solute carrier family 22 member 20 in Mouse [ChEMBL: CHEMBL5269] [GtoPdb: 1037] [UniProtKB: Q80UJ1]
  • 5.95
10 CHEMBL521_lig_chart_10 Solute carrier family 22 member 20 Mouse
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  • Organic anion transporter 1/Solute carrier family 22 member 6 in Human [ChEMBL: CHEMBL1641347] [GtoPdb: 1025] [UniProtKB: Q4U2R8]
  • Organic anion transporter 1/Solute carrier family 22 member 6 in Mouse [ChEMBL: CHEMBL5653] [GtoPdb: 1025] [UniProtKB: Q8VC69]
  • Organic anion transporter 1/Solute carrier family 22 member 6 in Rat [ChEMBL: CHEMBL1777665] [GtoPdb: 1025] [UniProtKB: O35956]
  • 5.46
11 CHEMBL521_lig_chart_11 Solute carrier family 22 member 6 HumanMouseRat
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  • ASIC1 in Human [GtoPdb: 684] [UniProtKB: P78348]
  • This target only has 0 pki data point
  • 0
12 CHEMBL521_lig_chart_12 ASIC1 Human
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  • SMCT1 in Human [GtoPdb: 922] [UniProtKB: Q8N695]
  • This target only has 0 pki data point
  • 0
13 CHEMBL521_lig_chart_13 SMCT1 Human
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
AKR1C3/Aldo-keto-reductase family 1 member C3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4681] [GtoPdb: 1382] [UniProtKB: P42330]
ChEMBL Inhibition of recombinant human AKR1C3 B 4.48 pIC50 33000 nM IC50 Bioorg. Med. Chem. Lett. (2005) 15: 5170-5175 [PMID:16183274]
ChEMBL Inhibition of AKR1C3 (unknown origin) B 5 pIC50 10000 nM IC50 MedChemComm (2018) 9: 969-981
5-LOX/Arachidonate 5-lipoxygenase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL215] [GtoPdb: 1385] [UniProtKB: P09917]
ChEMBL Inhibitory activity against 5-lipoxygenase in Human whole blood (HWBL) stimulated with calcium ionophore (A23187) and LTB4 measured by enzyme immunoassay F 4.77 pIC50 17000 nM IC50 J. Med. Chem. (1997) 40: 819-824 [PMID:9057869]
5-LOX/Arachidonate 5-lipoxygenase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL312] [GtoPdb: 1385] [UniProtKB: P12527]
ChEMBL Inhibition of 5-LOX in RBL1 cells assessed as reduction in LTB4 production using A23187-induced arachidonic acid as substrate preincubated for 2 hrs followed by A23187 addition measured after 15 mins by LC-MS/MS analysis B 4 pIC50 >100000 nM IC50 ACS Med Chem Lett (2017) 8: 864-868 [PMID:28835803]
ChEMBL Inhibitory activity against 5-lipoxygenase catalysis (5-LO) in sonicated rat basophilic leukemia cell lysate F 4.85 pIC50 14000 nM IC50 J. Med. Chem. (1997) 40: 819-824 [PMID:9057869]
COX-1 /Cyclooxygenase-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL221] [GtoPdb: 1375] [UniProtKB: P23219]
ChEMBL Inhibition of PGHS1 assessed as conversion of arachidonic acid to prostaglandin B 4.6 pIC50 25000 nM IC50 J. Nat. Prod. (1999) 62: 294-296 [PMID:10075763]
ChEMBL Inhibition of COX1-catalyzed prostaglandin biosynthesis 10 mins of preincubation B 4.74 pIC50 18000 nM IC50 J. Nat. Prod. (1998) 61: 1212-1215 [PMID:9784154]
ChEMBL Inhibition activity against recombinant human Prostaglandin G/H synthase 1 B 4.95 pIC50 11100 nM IC50 J. Med. Chem. (1997) 40: 819-824 [PMID:9057869]
ChEMBL Inhibition of COX1 in human whole blood after 15 mins B 5.16 pIC50 6900 nM IC50 Bioorg. Med. Chem. (2007) 15: 4876-4890 [PMID:17517512]
ChEMBL Compound was evaluated for inhibition of Prostaglandin G/H synthase 1 B 5.2 pIC50 6300 nM IC50 Bioorg. Med. Chem. Lett. (1996) 6: 707-712
GtoPdb - - 5.52 pIC50 3000 nM IC50 J Med Chem (1998) 41: 1124-37 [PMID:9544212]
ChEMBL Inhibition of Prostaglandin G/H synthase 1 (COX-1). B 5.52 pIC50 3000 nM IC50 J. Med. Chem. (1998) 41: 1124-1137 [PMID:9544212]
ChEMBL Concentration (in uM) to inhibit 50% of Prostaglandin G/H synthase 1 (COX-1) and is expressed in IC50. B 5.52 pIC50 3000 nM IC50 J. Med. Chem. (1998) 41: 1112-1123 [PMID:9544211]
ChEMBL Inhibitory activity against prostaglandin G/H synthase 1 (COX-1) B 5.52 pIC50 3000 nM IC50 J. Med. Chem. (1998) 41: 3515-3529 [PMID:9719605]
ChEMBL Inhibition of COX-1 in human washed platelet assessed as inhibition of 10 uM arachidonic acid-induced TXB2 formation incubated for 25 mins prior to arachidonic acid challenge measured after 30 mins by radioimmunoassay B 5.73 pIC50 1860 nM IC50 J. Med. Chem. (2013) 56: 4277-4299 [PMID:23651359]
ChEMBL Inhibition of COX-1 in human washed platelet assessed as inhibition of 0.5 uM arachidonic acid-induced TXB2 formation incubated for 25 mins prior to arachidonic acid challenge measured after 30 mins by radioimmunoassay B 6.54 pIC50 290 nM IC50 J. Med. Chem. (2013) 56: 4277-4299 [PMID:23651359]
ChEMBL DRUGMATRIX: Cyclooxygenase COX-1 enzyme inhibition (substrate: Arachidonic acid) B 6.67 pIC50 212 nM IC50 DrugMatrix in vitro pharmacology data
Cyclooxygenase-1 in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2860] [UniProtKB: O62664]
ChEMBL Inhibition of bovine seminal microsomal COX1 assessed as PGE2 production preincubated for 10 mins B 4.74 pIC50 18000 nM IC50 J. Nat. Prod. (1998) 61: 2-7 [PMID:9461646]
ChEMBL Inhibition of bovine seminal microsomal COX1 assessed as PGE2 production B 4.89 pIC50 13000 nM IC50 J. Nat. Prod. (1998) 61: 2-7 [PMID:9461646]
ChEMBL Inhibition of bovine COX1 by enzyme immunoassay B 5.54 pIC50 2900 nM IC50 J. Med. Chem. (2009) 52: 1525-1529 [PMID:19296694]
ChEMBL Inhibition of bovine COX-1 by enzyme immuno assay B 5.54 pIC50 2900 nM IC50 Bioorg. Med. Chem. Lett. (2009) 19: 6855-6861 [PMID:19884005]
Cyclooxygenase-1 in Sheep (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2949] [UniProtKB: P05979]
ChEMBL Inhibition of sheep placental cotyledons COX1 B 5.05 pKi 9000 nM Ki J. Med. Chem. (2011) 54: 8555-8562 [PMID:22091869]
ChEMBL Inhibition of ovine COX1 using arachidonic acid as substrate pretreated for 3 mins followed by substrate addition measured immediately B 4.14 pIC50 72800 nM IC50 J Nat Prod (2017) 80: 2472-2477 [PMID:28885836]
ChEMBL Inhibition of ovine COX-1 assessed as decrease in PGH2 production using arachidonic acid as substrate treated with enzyme for 10 mins prior to substrate challenge for 2 mins by enzyme immunoassay B 4.59 pIC50 26000 nM IC50 Bioorg. Med. Chem. Lett. (2014) 24: 1958-1962 [PMID:24656662]
ChEMBL Inhibitory concentration against Prostaglandin G/H synthase 1 of ram seminal vesicles at 100 uM B 4.84 pIC50 14400 nM IC50 Bioorg. Med. Chem. Lett. (2005) 15: 1793-1797 [PMID:15780608]
ChEMBL Inhibition of ovine COX-1 assessed as residual activity by measuring formation of 12-HHT from arachidonic acid by HPLC analysis B 4.92 pIC50 12000 nM IC50 Bioorg. Med. Chem. (2011) 19: 5372-5382 [PMID:21873070]
ChEMBL Inhibition of ovine COX1 after 5 mins B 4.92 pIC50 12000 nM IC50 J. Med. Chem. (2010) 53: 4691-4700 [PMID:20503989]
ChEMBL Inhibition of purified ovine COX1 pre-treated for 1 hr before 10-acetyl-3,7-dihydroxyphenoxazin substrate addition in absence of porcine liver esterase by fluorescence assay B 5 pIC50 10100 nM IC50 ACS Med. Chem. Lett. (2014) 5: 983-988 [PMID:25221653]
ChEMBL Inhibition of Ovine COX-1 preincubated for 15 mins by fluorescence analysis B 5 pIC50 >10000 nM IC50 ACS Med. Chem. Lett. (2015) 6: 1086-1090 [PMID:26487917]
ChEMBL Tested for inhibitory activity against Prostaglandin G/H synthase 1 from ovine B 5.05 pIC50 9000 nM IC50 J. Med. Chem. (1995) 38: 3895-3901 [PMID:7562922]
ChEMBL Inhibition of ram seminal vesicle COX1 assessed as reduction in PGE2 formation pre-incubated for 5 mins before arachidonic acid addition and measured after 20 mins by ELISA B 5.2 pIC50 6300 nM IC50 J Nat Prod (2017) 80: 999-1006 [PMID:28322565]
ChEMBL Inhibition of ovine COX1 pre-incubated for 10 mins before arachidonic acid substrate addition by enzyme immunoassay B 5.3 pIC50 5000 nM IC50 J. Med. Chem. (2012) 55: 8807-8826 [PMID:23043222]
ChEMBL Inhibition of ovine COX1 using arachidonic acid as substrate pretreated for 5 mins followed by substrate addition and measured after 2 mins by fluorescence based enzyme immunoassay B 5.39 pIC50 4120 nM IC50 Eur J Med Chem (2019) 180: 86-98 [PMID:31301566]
ChEMBL Inhibition of ovine COX-1 B 5.4 pIC50 4000 nM IC50 J. Med. Chem. (2011) 54: 1356-1364 [PMID:21280601]
ChEMBL In vitro inhibitory concentration against COX-1 enzyme B 5.54 pIC50 2900 nM IC50 J. Med. Chem. (2005) 48: 4061-4067 [PMID:15943479]
ChEMBL Inhibition of sheep COX1 by enzyme immunoassay B 5.54 pIC50 2900 nM IC50 Bioorg. Med. Chem. Lett. (2010) 20: 4544-4549 [PMID:20576432]
ChEMBL Inhibition of ovine COX1 by enzyme immuno assay B 5.54 pIC50 2900 nM IC50 Bioorg. Med. Chem. (2007) 15: 4767-4774 [PMID:17509888]
ChEMBL Inhibition of ovine COX1 by enzyme immuno assay B 5.54 pIC50 2900 nM IC50 Bioorg. Med. Chem. Lett. (2010) 20: 2168-2173 [PMID:20202839]
ChEMBL Inhibition of ovine COX1 by enzyme immuno assay B 5.54 pIC50 2900 nM IC50 Bioorg. Med. Chem. Lett. (2011) 21: 3951-3956 [PMID:21641217]
ChEMBL Inhibition of ovine COX1 by enzyme immuno assay B 5.54 pIC50 2900 nM IC50 Bioorg. Med. Chem. Lett. (2010) 20: 896-902 [PMID:20045320]
ChEMBL Inhibition of ovine COX1 by enzyme immuno assay B 5.54 pIC50 2900 nM IC50 Bioorg. Med. Chem. Lett. (2011) 21: 6074-6080 [PMID:21890358]
ChEMBL Inhibition of ovine COX1 B 5.54 pIC50 2900 nM IC50 J. Med. Chem. (2012) 55: 688-696 [PMID:22148253]
ChEMBL Inhibition of ovine COX1 by enzyme immunoassay B 5.54 pIC50 2900 nM IC50 Bioorg. Med. Chem. Lett. (2010) 20: 1324-1329 [PMID:20097072]
ChEMBL Inhibition of ovine COX1 B 5.54 pIC50 2900 nM IC50 Bioorg. Med. Chem. Lett. (2013) 23: 163-168 [PMID:23200247]
ChEMBL Inhibition of ovine COX1 by enzyme immunoassay B 5.54 pIC50 2900 nM IC50 Bioorg. Med. Chem. (2009) 17: 5182-5188 [PMID:19500994]
ChEMBL Inhibition of ovine COX1 by enzyme immunoassay B 5.54 pIC50 2900 nM IC50 Bioorg. Med. Chem. Lett. (2009) 19: 3014-3018 [PMID:19419861]
ChEMBL Inhibition of ovine COX1 by enzyme immuno assay B 5.54 pIC50 2900 nM IC50 Bioorg. Med. Chem. Lett. (2009) 19: 584-588 [PMID:19136259]
ChEMBL Inhibition of ovine COX1 by enzyme immuno assay B 5.54 pIC50 2900 nM IC50 Bioorg. Med. Chem. Lett. (2016) 26: 406-412 [PMID:26691756]
ChEMBL Inhibition of ovine COX1 by enzyme immuno assay B 5.54 pIC50 2900 nM IC50 Bioorg. Med. Chem. (2008) 16: 9694-9698 [PMID:18930406]
ChEMBL Inhibition of ovine COX1 assessed as reduction in Prostaglandin production by enzyme immunoassay B 5.85 pIC50 1420 nM IC50 Bioorg Med Chem (2018) 26: 891-902 [PMID:29373271]
ChEMBL Reversible competitive inhibition of prostaglandin G/H synthase 1 B 5.97 pIC50 1060 nM IC50 Bioorg. Med. Chem. Lett. (2004) 14: 667-671 [PMID:14741265]
COX-2 /Cyclooxygenase-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL230] [GtoPdb: 1376] [UniProtKB: P35354]
ChEMBL Inhibition of human recombinant COX-2 assessed as residual activity by measuring formation of 12-HHT from arachidonic acid by HPLC analysis B 4.1 pIC50 80000 nM IC50 Bioorg. Med. Chem. (2011) 19: 5372-5382 [PMID:21873070]
ChEMBL Inhibition of human recombinant COX2 after 5 mins B 4.1 pIC50 80000 nM IC50 J. Med. Chem. (2010) 53: 4691-4700 [PMID:20503989]
ChEMBL Inhibition of human COX2 pre-incubated for 10 mins before substrate addition by enzyme immunoassay B 4.44 pIC50 36000 nM IC50 J. Med. Chem. (2012) 55: 8807-8826 [PMID:23043222]
ChEMBL Inhibition of Prostaglandin G/H synthase 2 (COX-2). B 4.52 pIC50 30000 nM IC50 J. Med. Chem. (1998) 41: 1124-1137 [PMID:9544212]
ChEMBL Concentration (in uM) to inhibit 50% of Prostaglandin G/H synthase 2 (COX-2) and is expressed in IC50. B 4.52 pIC50 30000 nM IC50 J. Med. Chem. (1998) 41: 1112-1123 [PMID:9544211]
ChEMBL Inhibitory activity against prostaglandin G/H synthase 2 (COX-2) B 4.52 pIC50 30000 nM IC50 J. Med. Chem. (1998) 41: 3515-3529 [PMID:9719605]
ChEMBL Inhibition of human recombinant COX-2 assessed as decrease in PGH2 production using arachidonic acid as substrate treated with enzyme for 10 mins prior to substrate challenge for 2 mins by enzyme immunoassay B 4.52 pIC50 30000 nM IC50 Bioorg. Med. Chem. Lett. (2014) 24: 1958-1962 [PMID:24656662]
ChEMBL DRUGMATRIX: Cyclooxygenase COX-2 enzyme inhibition (substrate: Arachidonic acid) B 4.59 pIC50 25530 nM IC50 DrugMatrix in vitro pharmacology data
ChEMBL Inhibition of COX2 (unknown origin) B 4.84 pIC50 14500 nM IC50 Eur J Med Chem (2017) 138: 1002-1033 [PMID:28759875]
ChEMBL Inhibition of recombinant human COX2 using arachidonic acid as substrate pretreated for 5 mins followed by substrate addition and measured after 2 mins by fluorescence based enzyme immunoassay B 5.05 pIC50 8910 nM IC50 Eur J Med Chem (2019) 180: 86-98 [PMID:31301566]
ChEMBL Tested for inhibitory activity against Prostaglandin G/H synthase 2 from human B 5.1 pIC50 8000 nM IC50 J. Med. Chem. (1995) 38: 3895-3901 [PMID:7562922]
ChEMBL Inhibition of COX2 in human whole blood after 15 mins B 5.21 pIC50 6200 nM IC50 Bioorg. Med. Chem. (2007) 15: 4876-4890 [PMID:17517512]
ChEMBL Inhibition of human recombinant COX2 pre-treated for 1 hr before 10-acetyl-3,7-dihydroxyphenoxazin substrate addition in absence of porcine liver esterase by fluorescence assay B 5.37 pIC50 4300 nM IC50 ACS Med. Chem. Lett. (2014) 5: 983-988 [PMID:25221653]
ChEMBL Inhibition of human recombinant COX2 assessed as reduction in PGE2 formation pre-incubated for 5 mins before arachidonic acid addition and measured after 20 mins by ELISA B 5.38 pIC50 4200 nM IC50 J Nat Prod (2017) 80: 999-1006 [PMID:28322565]
ChEMBL Inhibition of human recombinant COX2 assessed as reduction in PGE2 production using arachidonic acid substrate by ELISA B 5.7 pIC50 2000 nM IC50 J Nat Prod (2019) 82: 1839-1848 [PMID:31268709]
ChEMBL Inhibition of human recombinant COX-2 B 5.85 pIC50 1400 nM IC50 J. Med. Chem. (2011) 54: 1356-1364 [PMID:21280601]
ChEMBL Inhibition of human COX2 expressed in baculovirus system B 5.87 pIC50 1350 nM IC50 J. Med. Chem. (2011) 54: 8555-8562 [PMID:22091869]
GtoPdb - - 5.87 pIC50 1350 nM IC50 J Med Chem (2011) 54: 8555-62 [PMID:22091869]
ChEMBL Inhibition of human recombinant COX-2 by enzyme immuno assay B 5.96 pIC50 1100 nM IC50 Bioorg. Med. Chem. Lett. (2009) 19: 6855-6861 [PMID:19884005]
ChEMBL Inhibition of human recombinant COX2 by enzyme immunoassay B 5.96 pIC50 1100 nM IC50 Bioorg. Med. Chem. Lett. (2010) 20: 1324-1329 [PMID:20097072]
ChEMBL Inhibition of human recombinant COX2 by enzyme immuno assay B 5.96 pIC50 1100 nM IC50 Bioorg. Med. Chem. Lett. (2010) 20: 2168-2173 [PMID:20202839]
ChEMBL Inhibition of human COX2 by enzyme immunoassay B 5.96 pIC50 1100 nM IC50 Bioorg. Med. Chem. Lett. (2010) 20: 4544-4549 [PMID:20576432]
ChEMBL Inhibition of human recombinant COX2 by enzyme immuno assay B 5.96 pIC50 1100 nM IC50 Bioorg. Med. Chem. Lett. (2011) 21: 3951-3956 [PMID:21641217]
ChEMBL Inhibition of human recombinant COX2 B 5.96 pIC50 1100 nM IC50 J. Med. Chem. (2012) 55: 688-696 [PMID:22148253]
ChEMBL Inhibition of human recombinant COX2 B 5.96 pIC50 1100 nM IC50 Bioorg. Med. Chem. Lett. (2013) 23: 163-168 [PMID:23200247]
ChEMBL Inhibition of recombinant human COX-2 preincubated for 15 mins by fluorescence analysis B 5.96 pIC50 1100 nM IC50 ACS Med. Chem. Lett. (2015) 6: 1086-1090 [PMID:26487917]
ChEMBL Inhibition of human recombinant COX2 by enzyme immuno assay B 5.96 pIC50 1100 nM IC50 Bioorg. Med. Chem. Lett. (2016) 26: 406-412 [PMID:26691756]
ChEMBL Inhibition of human recombinant COX2 by enzyme immunoassay B 5.96 pIC50 1100 nM IC50 Bioorg. Med. Chem. (2009) 17: 5182-5188 [PMID:19500994]
ChEMBL Inhibition of recombinant human N-terminal His-tagged COX2 expressed in baculovirus infected Sf21 cells assessed as reduction in prostaglandin production by enzyme immunoassay B 5.97 pIC50 1080 nM IC50 Bioorg Med Chem (2018) 26: 891-902 [PMID:29373271]
ChEMBL Inhibition activity against recombinant human Prostaglandin G/H synthase 2 B 7 pIC50 100 nM IC50 J. Med. Chem. (1997) 40: 819-824 [PMID:9057869]
Cyclooxygenase-2 in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3331] [UniProtKB: O62698]
ChEMBL Inhibition of bovine COX2 by enzyme immunoassay B 5.96 pIC50 1100 nM IC50 J. Med. Chem. (2009) 52: 1525-1529 [PMID:19296694]
Cyclooxygenase-2 in Sheep (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4102] [UniProtKB: P79208]
ChEMBL Inhibition of sheep placental cotyledons COX2 B 5.05 pKi 9000 nM Ki J. Med. Chem. (2011) 54: 8555-8562 [PMID:22091869]
ChEMBL Inhibition of ovine COX2 assessed as reduction in PGH2 production by enzyme immunoassay B 5.85 pIC50 1400 nM IC50 Bioorg Med Chem (2018) 26: 4113-4126 [PMID:29980364]
ChEMBL Inhibition of ovine COX2 by enzyme immuno assay B 5.96 pIC50 1100 nM IC50 Bioorg. Med. Chem. (2007) 15: 4767-4774 [PMID:17509888]
ChEMBL Inhibition of ovine COX2 by enzyme immuno assay B 5.96 pIC50 1100 nM IC50 Bioorg. Med. Chem. (2008) 16: 9694-9698 [PMID:18930406]
ChEMBL Inhibition of ovine COX2 by enzyme immuno assay B 5.96 pIC50 1100 nM IC50 Bioorg. Med. Chem. Lett. (2009) 19: 584-588 [PMID:19136259]
ChEMBL In vitro inhibitory concentration against COX-2 enzyme B 5.96 pIC50 1100 nM IC50 J. Med. Chem. (2005) 48: 4061-4067 [PMID:15943479]
ChEMBL Inhibition of ovine COX2 by enzyme immuno assay B 5.96 pIC50 1100 nM IC50 Bioorg. Med. Chem. Lett. (2010) 20: 896-902 [PMID:20045320]
ChEMBL Inhibition of ovine COX2 by enzyme immuno assay B 5.96 pIC50 1100 nM IC50 Bioorg. Med. Chem. Lett. (2011) 21: 6074-6080 [PMID:21890358]
ChEMBL Inhibition of ovine COX2 by enzyme immunoassay B 5.96 pIC50 1100 nM IC50 Bioorg. Med. Chem. Lett. (2009) 19: 3014-3018 [PMID:19419861]
COX-2 /Cyclooxygenase-2 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4321] [GtoPdb: 1376] [UniProtKB: Q05769]
ChEMBL Inhibition of COX-2 in mouse RAW264.7 cells assessed as decrease in LPS-induced PGE2 production treated prior to LPS challenge by enzyme immunoassay B 6.07 pIC50 860 nM IC50 Bioorg. Med. Chem. Lett. (2014) 24: 1958-1962 [PMID:24656662]
Dehydrogenase/reductase SDR family member 9 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075220] [UniProtKB: Q8VD48]
ChEMBL Inhibition of rat liver 3-alpha-HSD assessed as 5-beta-dihydrocortisone reduction B 4 pIC50 100000 nM IC50 Bioorg. Med. Chem. (2007) 15: 4876-4890 [PMID:17517512]
epidermal growth factor receptor/Epidermal growth factor receptor erbB1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL203] [GtoPdb: 1797] [UniProtKB: P00533]
ChEMBL Inhibition of EGFR (unknown origin) using tyrosine 4 as substrate by fluorescence analysis B 5 pIC50 >10000 nM IC50 ACS Med. Chem. Lett. (2015) 6: 1086-1090 [PMID:26487917]
fatty acid binding protein 1/Fatty acid-binding protein, liver in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5738] [GtoPdb: 2531] [UniProtKB: P02692]
ChEMBL Displacement of 1-anilinonaphthalene-8-sulphonic acid from rat recombinant L-FABP high binding affinity site expressed in Escherichia coli BL21 by competitive fluorescence displacement assay B 4.32 pKi 47600 nM Ki J. Med. Chem. (2008) 51: 3755-3764 [PMID:18533710]
L-PGDS/Prostaglandin-H2 D-isomerase in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4334] [GtoPdb: 1380] [UniProtKB: O09114]
ChEMBL Concentration required to inhibit 50% activity of prostaglandin synthetase was determined in vitro in mouse brain microsomes B 4.89 pIC50 13000 nM IC50 J. Med. Chem. (1991) 34: 1099-1110 [PMID:1900533]
Serum albumin in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3728] [UniProtKB: P02769]
ChEMBL Binding affinity to bovine serum albumin B 5.52 pIC50 3000 nM IC50 Bioorg. Med. Chem. (2008) 16: 1162-1173 [PMID:18024138]
OAT6/Solute carrier family 22 member 20 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5269] [GtoPdb: 1037] [UniProtKB: Q80UJ1]
ChEMBL Inhibition of mouse Oat6-mediated [3H]ES uptake in Xenopus oocytes after 1 hr B 5.95 pKi 1122.02 nM Ki J. Biol. Chem. (2007) 282: 23841-23853 [PMID:17553798]
ChEMBL Inhibition of mouse Oat6-mediated [3H]ES uptake in Xenopus oocytes after 1 hr B 5.96 pKi 1100 nM Ki J. Biol. Chem. (2007) 282: 23841-23853 [PMID:17553798]
Organic anion transporter 1/Solute carrier family 22 member 6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1641347] [GtoPdb: 1025] [UniProtKB: Q4U2R8]
ChEMBL TP_TRANSPORTER: inhibition of Adefovir uptake in OAT1-expressing CHO cells F 5.1 pIC50 8000 nM IC50 J. Pharmacol. Exp. Ther. (2000) 295: 10-15 [PMID:10991954]
Organic anion transporter 1/Solute carrier family 22 member 6 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5653] [GtoPdb: 1025] [UniProtKB: Q8VC69]
ChEMBL Inhibition of mouse Oat1-mediated [3H]PAH uptake in Xenopus oocytes after 1 hr B 5.33 pKi 4700 nM Ki J. Biol. Chem. (2007) 282: 23841-23853 [PMID:17553798]
ChEMBL Inhibition of mouse Oat1-mediated [3H]PAH uptake in Xenopus oocytes after 1 hr B 5.33 pKi 4677.35 nM Ki J. Biol. Chem. (2007) 282: 23841-23853 [PMID:17553798]
Organic anion transporter 1/Solute carrier family 22 member 6 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1777665] [GtoPdb: 1025] [UniProtKB: O35956]
ChEMBL TP_TRANSPORTER: inhibition of PAH uptake in Xenopus laevis oocytes F 5.46 pKi 3500 nM Ki Mol. Pharmacol. (1999) 55: 847-854 [PMID:10220563]
ASIC1 in Human [GtoPdb: 684] [UniProtKB: P78348]
GtoPdb - - 3.5 pIC50 ~350000 nM IC50 J Neurosci (2001) 21: 8026-33 [PMID:11588175];
J Med Chem (2017) 60: 8192-8200 [PMID:28949138]
SMCT1 in Human [GtoPdb: 922] [UniProtKB: Q8N695]
GtoPdb - - 4.2 pIC50 63095 nM IC50