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Gene and Protein Information  |
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| Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
| Human | - | 323 | 10p15.1 | AKR1C3 | aldo-keto reductase family 1 member C3 | |
| Mouse | - | 323 | 13 A1 | Akr1c18 | aldo-keto reductase family 1, member C18 | |
| Rat | - | 323 | 17q12.2 | Akr1c3 | aldo-keto reductase family 1, member C3 | |
| Previous and Unofficial Names |
| Aldo-keto reductase family 1 member C3 | prostaglandin F synthase | 17β-HSD 5 | 17β-hydroxysteroid dehydrogenase type 5 | 3α-hydroxysteroid dehydrogenase type 2 | dihydrodiol dehydrogenase 3 | dihydrodiol dehydrogenase type I | PGFS | hydroxysteroid (17-beta) dehydrogenase 5 | 20 alpha-hydroxysteroid dehydrogenase | 20-alpha-HSD | Akr1c18 | aldo-keto reductase family 1 member C18 | HSD1 | aldo-keto reductase family 1, member C3 | aldo-keto reductase family 1 |
| Database Links |
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| Alphafold | P42330 (Hs), Q8K023 (Mm), P51652 (Rn) |
| BRENDA | 1.1.1.188, 1.3.1.20, 1.1.1.213, 1.1.1.239, 1.1.1.64 |
| CATH/Gene3D | 3.20.20.100 |
| ChEMBL Target | CHEMBL4681 (Hs) |
| Ensembl Gene | ENSG00000196139 (Hs), ENSMUSG00000021214 (Mm), ENSRNOG00000017531 (Rn) |
| Entrez Gene | 8644 (Hs), 105349 (Mm), 171516 (Rn) |
| Human Protein Atlas | ENSG00000196139 (Hs) |
| KEGG Enzyme | 1.1.1.188, 1.3.1.20, 1.1.1.213, 1.1.1.239, 1.1.1.64 |
| KEGG Gene | hsa:8644 (Hs), mmu:105349 (Mm), rno:171516 (Rn) |
| OMIM | 603966 (Hs) |
| Pharos | P42330 (Hs) |
| UniProtKB | P42330 (Hs), Q8K023 (Mm), P51652 (Rn) |
| Wikipedia | AKR1C3 (Hs) |
| Enzyme Reaction |
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| Inhibitors (Human) |
| flufenamic acid, indomethacin, flavonoids such as 2'-hydroxyflavanone (pIC50 6.5) [2,4] |
Download all structure-activity data for this target as a CSV file 
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| Key to terms and symbols | View all chemical structures | Click column headers to sort | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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1. Lolli ML, Carnovale IM, Pippione AC, Wahlgren WY, Bonanni D, Marini E, Zonari D, Gallicchio M, Boscaro V, Goyal P et al.. (2019) Bioisosteres of Indomethacin as Inhibitors of Aldo-Keto Reductase 1C3. ACS Med Chem Lett, 10 (4): 437-443. DOI: 10.1021/acsmedchemlett.8b00484 [PMID:30996776]
2. Matsuura K, Shiraishi H, Hara A, Sato K, Deyashiki Y, Ninomiya M, Sakai S. (1998) Identification of a principal mRNA species for human 3alpha-hydroxysteroid dehydrogenase isoform (AKR1C3) that exhibits high prostaglandin D2 11-ketoreductase activity. J Biochem, 124 (5): 940-6. [PMID:9792917]
3. Qiu W, Zhou M, Mazumdar M, Azzi A, Ghanmi D, Luu-The V, Labrie F, Lin SX. (2007) Structure-based inhibitor design for an enzyme that binds different steroids: a potent inhibitor for human type 5 17beta-hydroxysteroid dehydrogenase. J Biol Chem, 282 (11): 8368-79. [PMID:17166832]
4. Skarydová L, Zivná L, Xiong G, Maser E, Wsól V. (2009) AKR1C3 as a potential target for the inhibitory effect of dietary flavonoids. Chem Biol Interact, 178 (1-3): 138-44. [PMID:19007764]
5. Verma K, Gupta N, Zang T, Wangtrakluldee P, Srivastava SK, Penning TM, Trippier PC. (2018) AKR1C3 Inhibitor KV-37 Exhibits Antineoplastic Effects and Potentiates Enzalutamide in Combination Therapy in Prostate Adenocarcinoma Cells. Mol Cancer Ther, 17 (9): 1833-1845. [PMID:29891491]
