lodoxamide [Ligand Id: 9743] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1201266 (Lodoxamide)
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
GPR35/G-protein coupled receptor 35 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1293267] [GtoPdb: 102] [UniProtKB: Q9HC97]
ChEMBL Agonist activity at human GPR35 expressed in CHO-K1 cells after 90 mins by beta-arrestin 2 recruitment assay B 5.4 pEC50 4000 nM EC50 J Med Chem (2017) 60: 362-372 [PMID:27976894]
GtoPdb In an AP-TGF-α shedding assay using GPR35 expressing HEK293 cells. - 9 pEC50 1 nM EC50 Br J Pharmacol (2018) 175: 154-161 [PMID:29068046]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]