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ChEMBL ligand: CHEMBL313714 |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL214] [GtoPdb: 1] [UniProtKB: P08908] | ||||||||
ChEMBL | Compound was tested for the displacement of [3H]5-HT binding to cloned 5-hydroxytryptamine 1A receptor stably expressed in CHO cells | B | 7.18 | pIC50 | 66 | nM | IC50 | J Med Chem (1999) 42: 4981-5001 [PMID:10585208] |
GtoPdb | - | - | 7.2 | pIC50 | - | - | - | J Med Chem (1999) 42: 4981-5001 [PMID:10585208] |
5-HT1B receptor/Serotonin 1b (5-HT1b) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1898] [GtoPdb: 2] [UniProtKB: P28222] | ||||||||
ChEMBL | Binding affinity to human cloned 5-hydroxytryptamine 1B receptor in CHO cells by [3H]5-HT binding displacement. | B | 6.73 | pIC50 | 185 | nM | IC50 | J Med Chem (1997) 40: 3497-3500 [PMID:9357514] |
GtoPdb | - | - | 6.8 | pIC50 | - | - | - | J Med Chem (1999) 42: 4981-5001 [PMID:10585208] |
ChEMBL | Displacement of [3H]5-HT binding to cloned 5-hydroxytryptamine 1B receptor stably expressed in CHO cells | B | 6.82 | pIC50 | 150 | nM | IC50 | J Med Chem (1999) 42: 4981-5001 [PMID:10585208] |
5-HT1D receptor/Serotonin 1d (5-HT1d) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1983] [GtoPdb: 3] [UniProtKB: P28221] | ||||||||
ChEMBL | Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in Chinese hamster ovary cells (CHO cells) | B | 9.05 | pKi | 0.9 | nM | Ki | Bioorg Med Chem Lett (2003) 13: 4409-4413 [PMID:14643336] |
GtoPdb | - | - | 9 | pIC50 | - | - | - | J Med Chem (1999) 42: 4981-5001 [PMID:10585208] |
ChEMBL | Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cells | B | 9.05 | pIC50 | 0.9 | nM | IC50 | J Med Chem (1998) 41: 2667-2670 [PMID:9667955] |
ChEMBL | Binding affinity by displacement to human cloned 5-hydroxytryptamine 1D receptor in CHO cells by [3H]5-HT displacement. | B | 9.05 | pIC50 | 0.9 | nM | IC50 | J Med Chem (1997) 40: 3497-3500 [PMID:9357514] |
ChEMBL | Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells | B | 9.05 | pIC50 | 0.9 | nM | IC50 | J Med Chem (1999) 42: 4981-5001 [PMID:10585208] |
ChEMBL | Agonist induced [35S]GTP-gamma-S, binding in CHO cells expressing 5-HT 1d receptor | F | 8.96 | pEC50 | 1.1 | nM | EC50 | J Med Chem (1998) 41: 2667-2670 [PMID:9667955] |
ChEMBL | Measurement of agonist induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor. | F | 8.96 | pEC50 | 1.1 | nM | EC50 | J Med Chem (1997) 40: 3497-3500 [PMID:9357514] |
ChEMBL | Agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor | B | 9.1 | pEC50 | 0.8 | nM | EC50 | J Med Chem (1999) 42: 4981-5001 [PMID:10585208] |
5-ht1e receptor/Serotonin 1e (5-HT1e) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2182] [GtoPdb: 4] [UniProtKB: P28566] | ||||||||
ChEMBL | Compound was tested for the displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1E receptor stably expressed in CHO cells | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (1999) 42: 4981-5001 [PMID:10585208] |
5-HT1F receptor/Serotonin 1f (5-HT1f) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1805] [GtoPdb: 5] [UniProtKB: P30939] | ||||||||
ChEMBL | Compound was tested for the displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1F receptor stably expressed in CHO cells | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (1999) 42: 4981-5001 [PMID:10585208] |
5-HT2A receptor/Serotonin 2a (5-HT2a) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL224] [GtoPdb: 6] [UniProtKB: P28223] | ||||||||
ChEMBL | Compound was tested for the displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 2A receptor stably expressed in CHO cells | B | 5.96 | pIC50 | 1100 | nM | IC50 | J Med Chem (1999) 42: 4981-5001 [PMID:10585208] |
5-HT5A receptor/Serotonin 5a (5-HT5a) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3426] [GtoPdb: 10] [UniProtKB: P47898] | ||||||||
ChEMBL | Compound was tested for the displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 5A receptor stably expressed in CHO cells | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (1999) 42: 4981-5001 [PMID:10585208] |
5-HT6 receptor/Serotonin 6 (5-HT6) receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3372] [GtoPdb: 11] [UniProtKB: P31388] | ||||||||
ChEMBL | Compound was tested for the displacement of [3H]5-HT binding to cloned rat 5-hydroxytryptamine 6 receptor stably expressed in CHO cells | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (1999) 42: 4981-5001 [PMID:10585208] |
5-HT7 receptor/Serotonin 7 (5-HT7) receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3223] [GtoPdb: 12] [UniProtKB: P32305] | ||||||||
ChEMBL | Compound was tested for the displacement of [3H]5-HT binding to cloned rat 5-hydroxytryptamine 7 receptor stably expressed in CHO cells | B | 6.27 | pIC50 | 540 | nM | IC50 | J Med Chem (1999) 42: 4981-5001 [PMID:10585208] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]