daltroban [Ligand Id: 1986] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL71685 (BM 13.505, BM-13505, BM13505, Daltroban, SK&F 96148, SKF-96148, SKF96148) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| TP receptor/Thromboxane A2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2069] [GtoPdb: 346] [UniProtKB: P21731] | ||||||||
| ChEMBL | Compound was tested for its binding affinity at Thromboxane A2/ Prostaglandin H2 receptor by measuring its ability to displace [3H]U-46619 from guinea pig platelets | B | 7.2 | pKi | 63 | nM | Ki | J Med Chem (1992) 35: 3402-3413 [PMID:1388208] |
| GtoPdb | - | - | 7.7 | pKi | - | - | - | Jpn J Pharmacol (1992) 59: 357-64 [PMID:1434130] |
| ChEMBL | In vitro thromboxane A2 antagonistic activity on aggregation of rabbit platelets induced by U-46,619 (4 uM) | F | 6.34 | pIC50 | 460 | nM | IC50 | Bioorg Med Chem Lett (1999) 9: 401-406 [PMID:10091692] |
| ChEMBL | In vitro thromboxane-A2 receptor binding affinity to displace by 50% [3H]-SQ 29548 binding from washed human platelets | B | 6.82 | pIC50 | 150 | nM | IC50 | J Med Chem (1994) 37: 3588-3604 [PMID:7932586] |
| TP receptor/Thromboxane A2 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3156] [GtoPdb: 346] [UniProtKB: P34978] | ||||||||
| ChEMBL | In vitro thromboxane A2 antagonistic activity on U-46619 (0.1 uM) induced contraction of rat aorta | F | 7.43 | pIC50 | 37.1 | nM | IC50 | Bioorg Med Chem Lett (1999) 9: 401-406 [PMID:10091692] |
| CYP5A1/Thromboxane-A synthase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4028] [GtoPdb: 1353] [UniProtKB: P49430] | ||||||||
| ChEMBL | In vitro inhibition of thromboxane-A2 synthase in rat whole blood during clotting at 37 degrees Centigrade | B | 4 | pIC50 | >100000 | nM | IC50 | J Med Chem (1994) 37: 3588-3604 [PMID:7932586] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
