ChEMBL ligand: CHEMBL1316 (Carprofen, Carprofene, Carprofen for veterinary use, Carprofeno, NSC-297935, Rimadyl, Ro-205720000, RO 20-5720/000)
Fatty acid amide hydrolase/Anandamide amidohydrolase in Rat [ChEMBL: CHEMBL3229] [GtoPdb: 1400] [UniProtKB: P97612] There should be some charts here, you may need to enable JavaScript!
Complement C5 in Human [ChEMBL: CHEMBL2364163] [UniProtKB: P01031] There should be some charts here, you may need to enable JavaScript!
COX-1 /Cyclooxygenase-1 in Human [ChEMBL: CHEMBL221] [GtoPdb: 1375] [UniProtKB: P23219] Cyclooxygenase-1 in Sheep [ChEMBL: CHEMBL2949] [UniProtKB: P05979] There should be some charts here, you may need to enable JavaScript!
COX-2 /Cyclooxygenase-2 in Human [ChEMBL: CHEMBL230] [GtoPdb: 1376] [UniProtKB: P35354] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
Fatty acid amide hydrolase/Anandamide amidohydrolase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3229] [GtoPdb: 1400] [UniProtKB: P97612]
ChEMBL	Inhibition of FAAH in rat brain homogenates pre-incubated for 10 mins before addition of [3H]anandamide and [3H]AEA substrates for 30 mins by liquid scintillation counting	B	4.1	pIC50	78600	nM	IC50	J Med Chem (2012) 55: 8807-8826 [PMID:23043222]
ChEMBL	Inhibition of rat brain FAAH using [3H]AEA as substrate	B	4.49	pIC50	32000	nM	IC50	Eur J Med Chem (2017) 136: 523-542 [PMID:28535469]
Complement C5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2364163] [UniProtKB: P01031]
ChEMBL	Binding affinity to human C5a assessed as dissociation constant after 1 hr by circular dichroism analysis	B	6.24	pKd	580	nM	Kd	Bioorg Med Chem (2019) 27: 115052-115052 [PMID:31447248]
COX-1 /Cyclooxygenase-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL221] [GtoPdb: 1375] [UniProtKB: P23219]
ChEMBL	Inhibition of COX1 in human whole blood	B	4.23	pIC50	59000	nM	IC50	Bioorg Med Chem Lett (2008) 18: 4655-4657 [PMID:18667313]
ChEMBL	Inhibitory activity against cell-free canine COX-1	B	4.88	pIC50	13200	nM	IC50	J Med Chem (2001) 44: 641-659 [PMID:11262075]
ChEMBL	Inhibition of human COX1	B	8.28	pIC50	5.3	nM	IC50	RSC Med Chem (2024) 15: 788-808 [PMID:38516587]
Cyclooxygenase-1 in Sheep (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2949] [UniProtKB: P05979]
ChEMBL	Inhibition of ovine COX1 pre-incubated for 10 mins before arachidonic acid substrate addition by enzyme immunoassay	B	4.65	pIC50	22300	nM	IC50	J Med Chem (2012) 55: 8807-8826 [PMID:23043222]
ChEMBL	Inhibition of ovine COX-1 assessed as residual activity by measuring formation of 12-HHT from arachidonic acid by HPLC analysis	B	4.88	pIC50	13200	nM	IC50	Bioorg Med Chem (2011) 19: 5372-5382 [PMID:21873070]
ChEMBL	Inhibition of ovine COX1 after 5 mins	B	4.89	pIC50	13000	nM	IC50	J Med Chem (2010) 53: 4691-4700 [PMID:20503989]
COX-2 /Cyclooxygenase-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL230] [GtoPdb: 1376] [UniProtKB: P35354]
ChEMBL	Inhibition of COX2 in human whole blood	B	4.42	pIC50	38000	nM	IC50	Bioorg Med Chem Lett (2008) 18: 4655-4657 [PMID:18667313]
ChEMBL	Inhibition of human COX2 pre-incubated for 10 mins before substrate addition by enzyme immunoassay	B	5.41	pIC50	3900	nM	IC50	J Med Chem (2012) 55: 8807-8826 [PMID:23043222]
GtoPdb	Inhibition of COX-2-induced conversion of arachadonic acid to 12-HHT.	-	6.99	pIC50	102	nM	IC50	Bioorg Med Chem (2011) 19: 5372-82 [PMID:21873070]
ChEMBL	Inhibitory activity against cell-free canine COX-2	B	6.99	pIC50	102	nM	IC50	J Med Chem (2001) 44: 641-659 [PMID:11262075]
ChEMBL	Inhibition of human recombinant COX-2 assessed as residual activity by measuring formation of 12-HHT from arachidonic acid by HPLC analysis	B	6.99	pIC50	102	nM	IC50	Bioorg Med Chem (2011) 19: 5372-5382 [PMID:21873070]
ChEMBL	Inhibition of human recombinant COX2 after 5 mins	B	7	pIC50	100	nM	IC50	J Med Chem (2010) 53: 4691-4700 [PMID:20503989]
ChEMBL	Inhibition of COX2 (unknown origin) fluorescence based analysis	B	8.28	pIC50	5.3	nM	IC50	RSC Med Chem (2024) 15: 788-808 [PMID:38516587]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]