JNJ-63533054 [Ligand Id: 8766] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL3633720
  • GPR139/Probable G-protein coupled receptor 139 in Human [ChEMBL: CHEMBL3632455] [GtoPdb: 130] [UniProtKB: Q6DWJ6]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
GPR139/Probable G-protein coupled receptor 139 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3632455] [GtoPdb: 130] [UniProtKB: Q6DWJ6]
GtoPdb - - 7.62 pKi 24 nM Ki Mol Pharmacol (2015) 88: 911-25 [PMID:26349500]
ChEMBL Agonist activity at human GPR139 receptor expressed in HEK293 cells assessed as calcium mobilization by FLIPR assay B 7.8 pEC50 16 nM EC50 ACS Med. Chem. Lett. (2015) 6: 1015-1018 [PMID:26396690]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]