esmolol [Ligand Id: 7178] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL768 (Esmolol, ASL-8052-001)
  • β1-adrenoceptor/Beta-1 adrenergic receptor in Human [ChEMBL: CHEMBL213] [GtoPdb: 28] [UniProtKB: P08588]
  • Beta-1 adrenergic receptor in Guinea pig [ChEMBL: CHEMBL5471] [UniProtKB: B0FL73]
1 CHEMBL768_lig_chart_1 Beta-1 adrenergic receptor HumanGuinea pig
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  • Beta-2 adrenergic receptor in Guinea pig [ChEMBL: CHEMBL5414] [UniProtKB: Q8K4Z4]
  • This target only has 0 pki data point
2 CHEMBL768_lig_chart_2 Beta-2 adrenergic receptor Guinea pig
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
β1-adrenoceptor/Beta-1 adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL213] [GtoPdb: 28] [UniProtKB: P08588]
GtoPdb - - 6.9 pKi 113.7 nM Ki National Toxicology Program: Dept of Health and Human Services.. DrugMatrix
ChEMBL DRUGMATRIX: Adrenergic beta1 radioligand binding (ligand: [125I] Cyanopindolol) B 6.94 pKi 113.7 nM Ki DrugMatrix in vitro pharmacology data
ChEMBL DRUGMATRIX: Adrenergic beta1 radioligand binding (ligand: [125I] Cyanopindolol) B 6.71 pIC50 197 nM IC50 DrugMatrix in vitro pharmacology data
Beta-1 adrenergic receptor in Guinea pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5471] [UniProtKB: B0FL73]
ChEMBL Ability to block Beta-1 adrenergic receptor in guinea pig right atria preparation B 7 pKd 100 nM Kd J. Med. Chem. (1982) 25: 1408-1412 [PMID:6130154]
ChEMBL Activity at beta-1 adrenergic receptor B 7 pKd 100 nM Kd J. Med. Chem. (1992) 35: 4676-4682 [PMID:1361581]
Beta-2 adrenergic receptor in Guinea pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5414] [UniProtKB: Q8K4Z4]
ChEMBL Ability to block Beta-2 adrenergic receptor in guinea pig trachea preparation B 5.2 pKd 6309.57 nM Kd J. Med. Chem. (1982) 25: 1408-1412 [PMID:6130154]

ChEMBL data shown on this page come from version 27:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]