esmolol [Ligand Id: 7178] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL768 (ASL-8052-001, Esmolol) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| β1-adrenoceptor/Beta-1 adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL213] [GtoPdb: 28] [UniProtKB: P08588] | ||||||||
| GtoPdb | - | - | 6.9 | pKi | - | - | - |
National Toxicology Program: Dept of Health and Human Services.. DrugMatrix; J Pharmacol Exp Ther (2016) 359: 73-81 [PMID:27451411] |
| ChEMBL | DRUGMATRIX: Adrenergic beta1 radioligand binding (ligand: [125I] Cyanopindolol) | B | 6.94 | pKi | 113.7 | nM | Ki | DrugMatrix in vitro pharmacology data |
| ChEMBL | DRUGMATRIX: Adrenergic beta1 radioligand binding (ligand: [125I] Cyanopindolol) | B | 6.71 | pIC50 | 197 | nM | IC50 | DrugMatrix in vitro pharmacology data |
| Beta-1 adrenergic receptor in Guinea pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5471] [UniProtKB: B0FL73] | ||||||||
| ChEMBL | Ability to block Beta-1 adrenergic receptor in guinea pig right atria preparation | B | 7 | pKd | 100 | nM | Kd | J Med Chem (1982) 25: 1408-1412 [PMID:6130154] |
| ChEMBL | Activity at beta-1 adrenergic receptor | B | 7 | pKd | 100 | nM | Kd | J Med Chem (1992) 35: 4676-4682 [PMID:1361581] |
| Beta-2 adrenergic receptor in Guinea pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5414] [UniProtKB: Q8K4Z4] | ||||||||
| ChEMBL | Ability to block Beta-2 adrenergic receptor in guinea pig trachea preparation | B | 5.2 | pKd | 6309.57 | nM | Kd | J Med Chem (1982) 25: 1408-1412 [PMID:6130154] |
ChEMBL data shown on this page come from version 35:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
