naproxen [Ligand Id: 5230] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL154
  • COX-1 in Human [GtoPdb: 1375] [UniProtKB: P23219]
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  • COX-2 in Human [GtoPdb: 1376] [UniProtKB: P35354]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
COX-1 in Human [GtoPdb: 1375] [UniProtKB: P23219]
GtoPdb - - 5.49 pIC50 3200 nM IC50 J. Med. Chem. (1997) 40: 819-24 [PMID:9057869]
COX-2 in Human [GtoPdb: 1376] [UniProtKB: P35354]
GtoPdb - - 5.6 pIC50 2500 nM IC50 J. Med. Chem. (1997) 40: 819-24 [PMID:9057869]

ChEMBL data shown on this page come from version 27:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]