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lipase E, hormone sensitive type

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Target not currently curated in GtoImmuPdb

Target id: 2593

Nomenclature: lipase E, hormone sensitive type

Abbreviated Name: LIPE

Family: Hydrolases & Lipases

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 1076 19q13.2 LIPE lipase E, hormone sensitive type
Mouse - 759 7 13.78 cM Lipe lipase, hormone sensitive
Rat - 1068 1q21 Lipe lipase E, hormone sensitive type
Previous and Unofficial Names Click here for help
HSL | lipase, hormone-sensitive | lipase, hormone sensitive | lipase E | lipase
Database Links Click here for help
Specialist databases
MEROPS S09.993 (Hs)
Other databases
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
RefSeq Nucleotide
RefSeq Protein
Enzyme Reaction Click here for help
EC Number:

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Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
compound 41 [PMID: 15026062] Small molecule or natural product Hs Inhibition 9.0 pIC50 1
pIC50 9.0 (IC50 1x10-9 M) [1]
Clinically-Relevant Mutations and Pathophysiology Click here for help
Disease:  Lipodystrophy, familial partial, type 6; FPLD6
Synonyms: Familial partial lipodystrophy [Disease Ontology: DOID:0050440]
Disease Ontology: DOID:0050440
OMIM: 615980


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1. de Jong JC, Sørensen LG, Tornqvist H, Jacobsen P. (2004) Carbazates as potent inhibitors of hormone-sensitive lipase. Bioorg Med Chem Lett, 14 (7): 1741-4. [PMID:15026062]

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