lipase E, hormone sensitive type | Hydrolases | IUPHAR/BPS Guide to PHARMACOLOGY

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lipase E, hormone sensitive type

Target not currently curated in GtoImmuPdb

Target id: 2593

Nomenclature: lipase E, hormone sensitive type

Abbreviated Name: LIPE

Family: Hydrolases

Annotation status:  image of an orange circle Annotated and awaiting review. Please contact us if you can help with reviewing.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 1076 19q13.1-q13.2 LIPE lipase E, hormone sensitive type
Mouse - 759 7 A3 Lipe lipase, hormone sensitive
Rat - 1068 1q21 Lipe lipase E
Previous and Unofficial Names
HSL | lipase, hormone-sensitive | lipase, hormone sensitive | lipase E | lipase
Database Links
Specialist databases
MEROPS S09.993 (Hs)
Other databases
BRENDA
CATH/Gene3D
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction
EC Number: 3.1.1.79

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
compound 41 [PMID: 15026062] Hs Inhibition 9.0 pIC50 1
pIC50 9.0 (IC50 1x10-9 M) [1]
Clinically-Relevant Mutations and Pathophysiology
Disease:  Lipodystrophy, familial partial, type 6; FPLD6
Synonyms: Familial partial lipodystrophy [Disease Ontology: DOID:0050440]
Disease Ontology: DOID:0050440
OMIM: 615980

References

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1. de Jong JC, Sørensen LG, Tornqvist H, Jacobsen P. (2004) Carbazates as potent inhibitors of hormone-sensitive lipase. Bioorg. Med. Chem. Lett., 14 (7): 1741-4. [PMID:15026062]

How to cite this page

Hydrolases: lipase E, hormone sensitive type. Last modified on 30/03/2016. Accessed on 18/09/2019. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2593.