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ChEMBL ligand: CHEMBL721 (Aerolein) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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DAT/Dopamine transporter in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL338] [GtoPdb: 927] [UniProtKB: P23977] | ||||||||
ChEMBL | Inhibition of [3H]dopamine uptake at DAT in rat brain striatal synaptosomes by liquid scintillation counting analysis | B | 4.28 | pIC50 | 52480.75 | nM | IC50 | J Med Chem (2017) 60: 839-885 [PMID:27996267] |
TRPA1/Transient receptor potential cation channel subfamily A member 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6007] [GtoPdb: 485] [UniProtKB: O75762] | ||||||||
ChEMBL | Agonist activity at human TRPA1 expressed in HEK293 cells assessed as increase in calcium influx by Fluo-4-AM dye based fluorescence assay | B | 4.57 | pEC50 | 27000 | nM | EC50 | Eur J Med Chem (2019) 170: 141-156 [PMID:30878828] |
ChEMBL | Agonist activity at human TRPA1 expressed in HEK293 cells assessed as increase in calcium influx by Fluo-4-AM dye based fluorescence assay | B | 4.57 | pEC50 | 26915.35 | nM | EC50 | Eur J Med Chem (2019) 170: 141-156 [PMID:30878828] |
GtoPdb | - | - | 5.3 | pEC50 | 5011 | nM | EC50 | Cell (2006) 124: 1269-82 [PMID:16564016] |
ChEMBL | Activation of TRPA1 | B | 5.3 | pEC50 | 5000 | nM | EC50 | Nature (2007) 445: 541-545 [PMID:17237762] |
ChEMBL | Agonist activity at human TRPA1 expressed in Xenopus oocytes assessed as increase in calcium influx by two electrode voltage clamp method | B | 5.3 | pEC50 | 5000 | nM | EC50 | Eur J Med Chem (2019) 170: 141-156 [PMID:30878828] |
ChEMBL | Activation of TRPA1 channel | B | 6.1 | pEC50 | 800 | nM | EC50 | J. Med. Chem. (2010) 53: 5085-5107 [PMID:20356305] |
ChEMBL data shown on this page come from version 28:
Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]