acrolein [Ligand Id: 2418] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL721 (Aerolein)
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  • TRPA1/Transient receptor potential cation channel subfamily A member 1 in Human [ChEMBL: CHEMBL6007] [GtoPdb: 485] [UniProtKB: O75762]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
DAT/Dopamine transporter in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL338] [GtoPdb: 927] [UniProtKB: P23977]
ChEMBL Inhibition of [3H]dopamine uptake at DAT in rat brain striatal synaptosomes by liquid scintillation counting analysis B 4.28 pIC50 52480.75 nM IC50 J Med Chem (2017) 60: 839-885 [PMID:27996267]
TRPA1/Transient receptor potential cation channel subfamily A member 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6007] [GtoPdb: 485] [UniProtKB: O75762]
ChEMBL Agonist activity at human TRPA1 expressed in HEK293 cells assessed as increase in calcium influx by Fluo-4-AM dye based fluorescence assay B 4.57 pEC50 27000 nM EC50 Eur J Med Chem (2019) 170: 141-156 [PMID:30878828]
ChEMBL Agonist activity at human TRPA1 expressed in HEK293 cells assessed as increase in calcium influx by Fluo-4-AM dye based fluorescence assay B 4.57 pEC50 26915.35 nM EC50 Eur J Med Chem (2019) 170: 141-156 [PMID:30878828]
GtoPdb - - 5.3 pEC50 5011 nM EC50 Cell (2006) 124: 1269-82 [PMID:16564016]
ChEMBL Activation of TRPA1 B 5.3 pEC50 5000 nM EC50 Nature (2007) 445: 541-545 [PMID:17237762]
ChEMBL Agonist activity at human TRPA1 expressed in Xenopus oocytes assessed as increase in calcium influx by two electrode voltage clamp method B 5.3 pEC50 5000 nM EC50 Eur J Med Chem (2019) 170: 141-156 [PMID:30878828]
ChEMBL Activation of TRPA1 channel B 6.1 pEC50 800 nM EC50 J. Med. Chem. (2010) 53: 5085-5107 [PMID:20356305]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]