gisadenafil [Ligand Id: 6558] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1928262 (Gisadenafil, UK-369003, UK-369,003)
  • phosphodiesterase 5A/Phosphodiesterase 5A in Human [ChEMBL: CHEMBL1827] [GtoPdb: 1304] [UniProtKB: O76074]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
phosphodiesterase 5A/Phosphodiesterase 5A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1827] [GtoPdb: 1304] [UniProtKB: O76074]
GtoPdb - - 8.9 pIC50 - - - Bioorg Med Chem (2012) 20: 498-509 [PMID:22100260]
ChEMBL Inhibition of human PDE5 isolated from corpus cavernosum after 30 to 60 mins by scintillation counting method B 8.91 pIC50 1.23 nM IC50 Bioorg. Med. Chem. (2012) 20: 498-509 [PMID:22100260]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]