tubercidin [Ligand Id: 4755] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL267099 (Tubercidin)
  • A1 receptor/Adenosine A1 receptor in Rat [ChEMBL: CHEMBL318] [GtoPdb: 18] [UniProtKB: P25099]
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  • heat shock protein family A (Hsp70) member 8/Heat shock cognate 71 kDa protein in Human [ChEMBL: CHEMBL1275223] [GtoPdb: 2543] [UniProtKB: P11142]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
A1 receptor/Adenosine A1 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL318] [GtoPdb: 18] [UniProtKB: P25099]
ChEMBL Binding affinity to adenosine A1 receptor in rat brain membranes by measuring displacement of specific [3H]PIA as radioligand. B 4 pKi >100000 nM Ki J. Med. Chem. (1995) 38: 1174-1188 [PMID:7707320]
Adenosine kinase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3589] [GtoPdb: 1231] [UniProtKB: P55263]
ChEMBL Inhibition of recombinant human adenosine kinase B 5 pIC50 10000 nM IC50 J. Med. Chem. (2000) 43: 2883-2893 [PMID:10956196]
heat shock protein family A (Hsp70) member 8/Heat shock cognate 71 kDa protein in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1275223] [GtoPdb: 2543] [UniProtKB: P11142]
ChEMBL Binding affinity to human truncated HSC70 NBD (1 to 381 residues) by SPR analysis B 4.55 pKd 28183.83 nM Kd J. Med. Chem. (2016) 59: 4625-4636 [PMID:27119979]
ChEMBL Binding affinity to human truncated HSC70 NBD (1 to 381 residues) by SPR analysis B 4.55 pKd 28000 nM Kd J. Med. Chem. (2016) 59: 4625-4636 [PMID:27119979]
NS5 in Zika virus (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4523952] [UniProtKB: A0A143MHK7]
ChEMBL Inhibition of RNA-dependent RNA polymerase in Zika virus MR766 infected in African green monkey Vero cells assessed as antiviral activity by measuring reduction in virus-induced cytopathic effect after 5 days by MTS assay B 5.89 pEC50 1300 nM EC50 J Med Chem (2020) 63: 470-489 [PMID:31549836]
ChEMBL Inhibition of RNA-dependent RNA polymerase in Zika virus MR766 infected in African green monkey Vero cells assessed as antiviral activity by measuring reduction in virus-yield B 5.89 pEC50 1300 nM EC50 J Med Chem (2020) 63: 470-489 [PMID:31549836]
ChEMBL Inhibition of RNA-dependent RNA polymerase in Zika virus MR766 infected in African green monkey Vero cells assessed as antiviral activity by methylene blue staining based by Plaque reduction assay B 5.89 pEC50 1300 nM EC50 J Med Chem (2020) 63: 470-489 [PMID:31549836]
ChEMBL Inhibition of RNA-dependent RNA polymerase in Zika virus MR766 infected in African green monkey Vero cells assessed as antiviral activity by Alexa Fluor 488/DAPI staining based assay B 5.89 pEC50 1300 nM EC50 J Med Chem (2020) 63: 470-489 [PMID:31549836]
Programmed cell death protein 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1781868] [UniProtKB: Q53EL6]
ChEMBL Stabilization of Pdcd4 expressed in human HEK293 cells assessed as inhibition of TPA-induced degradation by luciferase reporter assay B 6.06 pIC50 880 nM IC50 J. Nat. Prod. (2011) 74: 1990-1995 [PMID:21870828]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]