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ChEMBL ligand: CHEMBL267099 (Tubercidin) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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A1 receptor/Adenosine A1 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL318] [GtoPdb: 18] [UniProtKB: P25099] | ||||||||
ChEMBL | Binding affinity to adenosine A1 receptor in rat brain membranes by measuring displacement of specific [3H]PIA as radioligand. | B | 4 | pKi | >100000 | nM | Ki | J Med Chem (1995) 38: 1174-1188 [PMID:7707320] |
Adenosine kinase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3589] [GtoPdb: 1231] [UniProtKB: P55263] | ||||||||
ChEMBL | Inhibition of recombinant human adenosine kinase | B | 5 | pIC50 | 10000 | nM | IC50 | J Med Chem (2000) 43: 2883-2893 [PMID:10956196] |
heat shock protein family A (Hsp70) member 8/Heat shock cognate 71 kDa protein in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1275223] [GtoPdb: 2543] [UniProtKB: P11142] | ||||||||
ChEMBL | Binding affinity to human truncated HSC70 NBD (1 to 381 residues) by SPR analysis | B | 4.55 | pKd | 28183.83 | nM | Kd | J Med Chem (2016) 59: 4625-4636 [PMID:27119979] |
ChEMBL | Binding affinity to human truncated HSC70 NBD (1 to 381 residues) by SPR analysis | B | 4.55 | pKd | 28000 | nM | Kd | J Med Chem (2016) 59: 4625-4636 [PMID:27119979] |
NS5 in Zika virus (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4523952] [UniProtKB: A0A143MHK7] | ||||||||
ChEMBL | Inhibition of RNA-dependent RNA polymerase in Zika virus MR766 infected in African green monkey Vero cells assessed as antiviral activity by measuring reduction in virus-induced cytopathic effect after 5 days by MTS assay | B | 5.89 | pEC50 | 1300 | nM | EC50 | J Med Chem (2020) 63: 470-489 [PMID:31549836] |
ChEMBL | Inhibition of RNA-dependent RNA polymerase in Zika virus MR766 infected in African green monkey Vero cells assessed as antiviral activity by measuring reduction in virus-yield | B | 5.89 | pEC50 | 1300 | nM | EC50 | J Med Chem (2020) 63: 470-489 [PMID:31549836] |
ChEMBL | Inhibition of RNA-dependent RNA polymerase in Zika virus MR766 infected in African green monkey Vero cells assessed as antiviral activity by methylene blue staining based by Plaque reduction assay | B | 5.89 | pEC50 | 1300 | nM | EC50 | J Med Chem (2020) 63: 470-489 [PMID:31549836] |
ChEMBL | Inhibition of RNA-dependent RNA polymerase in Zika virus MR766 infected in African green monkey Vero cells assessed as antiviral activity by Alexa Fluor 488/DAPI staining based assay | B | 5.89 | pEC50 | 1300 | nM | EC50 | J Med Chem (2020) 63: 470-489 [PMID:31549836] |
Programmed cell death protein 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1781868] [UniProtKB: Q53EL6] | ||||||||
ChEMBL | Stabilization of Pdcd4 expressed in human HEK293 cells assessed as inhibition of TPA-induced degradation by luciferase reporter assay | B | 6.06 | pIC50 | 880 | nM | IC50 | J Nat Prod (2011) 74: 1990-1995 [PMID:21870828] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]