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Synonyms: SB-269,652 | SB-269652
Compound class: Synthetic organic
Comment: SB269652 was originally described as an allosteric antagonist at dopamine D3 and D2 receptors . Further analysis has revealed a novel mechanism of allostery, which relies on the presence of receptor dimers . SB269652 acts as a bitopic ligand , with one pharmacophore binding to one receptor protomer and the other pharmacophore allosterically modulating the binding of a ligand on the second partner in the dimer, in this instance rendering the compound a negative allosteric regulator of dopamine binding to the D2 receptor .
PubChem CID 9910352 represents the compound structure without specified stereochemistry.
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
|Compound class||Synthetic organic|
|SB-269,652 | SB-269652|
|GtoPdb PubChem SID||223366027|
|Search Google for chemical match using the InChIKey||JGLGOAQPUQITLD-OGAOHHHESA-N|
|Search Google for chemicals with the same backbone||JGLGOAQPUQITLD|
|Search UniChem for chemical match using the InChIKey||JGLGOAQPUQITLD-OGAOHHHESA-N|
|Search UniChem for chemicals with the same backbone||JGLGOAQPUQITLD|