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Molecular properties generated using the CDK
|Compound class||Synthetic organic|
|SB-269,652 | SB-269652|
|SB269652 was originally described as an allosteric antagonist at dopamine D3 and D2 receptors . Further analysis has revealed a novel mechanism of allostery, which relies on the presence of receptor dimers . SB269652 acts as a bitopic ligand , with one pharmacophore binding to one receptor protomer and the other pharmacophore allosterically modulating the binding of a ligand on the second partner in the dimer, in this instance rendering the compound a negative allosteric regulator of dopamine binding to the D2 receptor .
PubChem CID 9910352 represents the compound structure without specified stereochemistry.
|GtoPdb PubChem SID||223366027|
|Search Google for chemical match using the InChIKey||JGLGOAQPUQITLD-OGAOHHHESA-N|
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|Search UniChem for chemical match using the InChIKey||JGLGOAQPUQITLD-OGAOHHHESA-N|
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