ONO-AE2-227 [Ligand Id: 5824] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL3260772 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| EP4 receptor/Prostanoid EP4 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1836] [GtoPdb: 343] [UniProtKB: P35408] | ||||||||
| ChEMBL | Displacement of [3H]PGE2 from human prostanoid EP4 receptor expressed in cell membranes by scintillation counting | B | 8.15 | pKi | 7 | nM | Ki | Bioorg Med Chem Lett (2014) 24: 2212-2221 [PMID:24703233] |
| EP4 receptor in Mouse [GtoPdb: 343] [UniProtKB: P32240] | ||||||||
| GtoPdb | - | - | 8.57 | pKi | 2.7 | nM | Ki | Cancer Res (2002) 62: 28-32 [PMID:11782353] |
| EP3 receptor in Mouse [GtoPdb: 342] [UniProtKB: P30557] | ||||||||
| GtoPdb | - | - | 7.68 | pKi | 21 | nM | Ki | Cancer Res (2002) 62: 28-32 [PMID:11782353] |
| GtoPdb | - | - | 6.8 | pIC50 | 160 | nM | IC50 | Cancer Res (2002) 62: 28-32 [PMID:11782353] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
