compound 26 [PMID: 16190743] [Ligand Id: 2929] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL194419
  • S1P1 receptor/Sphingosine 1-phosphate receptor Edg-1 in Human [ChEMBL: CHEMBL4333] [GtoPdb: 275] [UniProtKB: P21453]
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  • S1P3 receptor/Sphingosine 1-phosphate receptor Edg-3 in Human [ChEMBL: CHEMBL3892] [GtoPdb: 277] [UniProtKB: Q99500]
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  • S1P2 receptor/Sphingosine 1-phosphate receptor Edg-5 in Human [ChEMBL: CHEMBL2955] [GtoPdb: 276] [UniProtKB: O95136]
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  • S1P4 receptor/Sphingosine 1-phosphate receptor Edg-6 in Human [ChEMBL: CHEMBL3230] [GtoPdb: 278] [UniProtKB: O95977]
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  • S1P5 receptor/Sphingosine 1-phosphate receptor Edg-8 in Human [ChEMBL: CHEMBL2274] [GtoPdb: 279] [UniProtKB: Q9H228]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
S1P1 receptor/Sphingosine 1-phosphate receptor Edg-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4333] [GtoPdb: 275] [UniProtKB: P21453]
GtoPdb - - 9.22 pIC50 - - - J Med Chem (2005) 48: 6169-73 [PMID:16190743]
ChEMBL Concentration required for displacement of [33P]-labeled S1P from human sphingosine 1-phosphate receptor 1 expressed in CHO cells B 9.22 pIC50 0.6 nM IC50 J Med Chem (2005) 48: 6169-6173 [PMID:16190743]
ChEMBL Displacement of [33P]S1P from human S1P1 receptor expressed in CHO cells B 9.22 pIC50 0.6 nM IC50 Bioorg Med Chem Lett (2006) 16: 3564-3568 [PMID:16621543]
ChEMBL Displacement of [33P]S1P from human S1P1R expressed in CHO cell membranes B 9.22 pIC50 0.6 nM IC50 ACS Med Chem Lett (2011) 2: 97-101 [PMID:24900286]
S1P3 receptor/Sphingosine 1-phosphate receptor Edg-3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3892] [GtoPdb: 277] [UniProtKB: Q99500]
GtoPdb - - 4.9 pIC50 - - - J Med Chem (2005) 48: 6169-73 [PMID:16190743]
ChEMBL Concentration required for displacement of [33P]-labeled S1P from human sphingosine 1-phosphate receptor 3 expressed in CHO cells B 4.92 pIC50 12000 nM IC50 J Med Chem (2005) 48: 6169-6173 [PMID:16190743]
ChEMBL Displacement of [33P]S1P from human S1P3 receptor expressed in CHO cells B 4.92 pIC50 12000 nM IC50 Bioorg Med Chem Lett (2006) 16: 3564-3568 [PMID:16621543]
ChEMBL Displacement of [33P]S1P from human S1P3R expressed in CHO cell membranes B 7.92 pIC50 12 nM IC50 ACS Med Chem Lett (2011) 2: 97-101 [PMID:24900286]
S1P2 receptor/Sphingosine 1-phosphate receptor Edg-5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2955] [GtoPdb: 276] [UniProtKB: O95136]
ChEMBL Concentration required for displacement of [33P]-labeled S1P from human sphingosine 1-phosphate receptor 2 expressed in CHO cells B 5 pIC50 >10000 nM IC50 J Med Chem (2005) 48: 6169-6173 [PMID:16190743]
ChEMBL Displacement of [33P]S1P from human S1P2 receptor expressed in CHO cells B 5 pIC50 >10000 nM IC50 Bioorg Med Chem Lett (2006) 16: 3564-3568 [PMID:16621543]
S1P4 receptor/Sphingosine 1-phosphate receptor Edg-6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3230] [GtoPdb: 278] [UniProtKB: O95977]
GtoPdb - - 7.15 pIC50 - - - J Med Chem (2005) 48: 6169-73 [PMID:16190743]
ChEMBL Concentration required for displacement of [33P]-labeled S1P from human sphingosine 1-phosphate receptor 4 expressed in CHO cells B 7.15 pIC50 70 nM IC50 J Med Chem (2005) 48: 6169-6173 [PMID:16190743]
ChEMBL Displacement of [33P]S1P from human S1P4 receptor expressed in CHO cells B 7.15 pIC50 70 nM IC50 Bioorg Med Chem Lett (2006) 16: 3564-3568 [PMID:16621543]
S1P5 receptor/Sphingosine 1-phosphate receptor Edg-8 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2274] [GtoPdb: 279] [UniProtKB: Q9H228]
GtoPdb - - 9 pIC50 - - - J Med Chem (2005) 48: 6169-73 [PMID:16190743]
ChEMBL Concentration required for displacement of [33P]-labeled S1P from human sphingosine 1-phosphate receptor 5 expressed in CHO cells B 9 pIC50 1 nM IC50 J Med Chem (2005) 48: 6169-6173 [PMID:16190743]
ChEMBL Displacement of [33P]S1P from human S1P5 receptor expressed in CHO cells B 9 pIC50 1 nM IC50 Bioorg Med Chem Lett (2006) 16: 3564-3568 [PMID:16621543]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]