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ChEMBL ligand: CHEMBL194419 |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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S1P1 receptor/Sphingosine 1-phosphate receptor Edg-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4333] [GtoPdb: 275] [UniProtKB: P21453] | ||||||||
GtoPdb | - | - | 9.22 | pIC50 | - | - | - | J Med Chem (2005) 48: 6169-73 [PMID:16190743] |
ChEMBL | Concentration required for displacement of [33P]-labeled S1P from human sphingosine 1-phosphate receptor 1 expressed in CHO cells | B | 9.22 | pIC50 | 0.6 | nM | IC50 | J Med Chem (2005) 48: 6169-6173 [PMID:16190743] |
ChEMBL | Displacement of [33P]S1P from human S1P1 receptor expressed in CHO cells | B | 9.22 | pIC50 | 0.6 | nM | IC50 | Bioorg Med Chem Lett (2006) 16: 3564-3568 [PMID:16621543] |
ChEMBL | Displacement of [33P]S1P from human S1P1R expressed in CHO cell membranes | B | 9.22 | pIC50 | 0.6 | nM | IC50 | ACS Med Chem Lett (2011) 2: 97-101 [PMID:24900286] |
S1P3 receptor/Sphingosine 1-phosphate receptor Edg-3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3892] [GtoPdb: 277] [UniProtKB: Q99500] | ||||||||
GtoPdb | - | - | 4.9 | pIC50 | - | - | - | J Med Chem (2005) 48: 6169-73 [PMID:16190743] |
ChEMBL | Concentration required for displacement of [33P]-labeled S1P from human sphingosine 1-phosphate receptor 3 expressed in CHO cells | B | 4.92 | pIC50 | 12000 | nM | IC50 | J Med Chem (2005) 48: 6169-6173 [PMID:16190743] |
ChEMBL | Displacement of [33P]S1P from human S1P3 receptor expressed in CHO cells | B | 4.92 | pIC50 | 12000 | nM | IC50 | Bioorg Med Chem Lett (2006) 16: 3564-3568 [PMID:16621543] |
ChEMBL | Displacement of [33P]S1P from human S1P3R expressed in CHO cell membranes | B | 7.92 | pIC50 | 12 | nM | IC50 | ACS Med Chem Lett (2011) 2: 97-101 [PMID:24900286] |
S1P2 receptor/Sphingosine 1-phosphate receptor Edg-5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2955] [GtoPdb: 276] [UniProtKB: O95136] | ||||||||
ChEMBL | Concentration required for displacement of [33P]-labeled S1P from human sphingosine 1-phosphate receptor 2 expressed in CHO cells | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2005) 48: 6169-6173 [PMID:16190743] |
ChEMBL | Displacement of [33P]S1P from human S1P2 receptor expressed in CHO cells | B | 5 | pIC50 | >10000 | nM | IC50 | Bioorg Med Chem Lett (2006) 16: 3564-3568 [PMID:16621543] |
S1P4 receptor/Sphingosine 1-phosphate receptor Edg-6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3230] [GtoPdb: 278] [UniProtKB: O95977] | ||||||||
GtoPdb | - | - | 7.15 | pIC50 | - | - | - | J Med Chem (2005) 48: 6169-73 [PMID:16190743] |
ChEMBL | Concentration required for displacement of [33P]-labeled S1P from human sphingosine 1-phosphate receptor 4 expressed in CHO cells | B | 7.15 | pIC50 | 70 | nM | IC50 | J Med Chem (2005) 48: 6169-6173 [PMID:16190743] |
ChEMBL | Displacement of [33P]S1P from human S1P4 receptor expressed in CHO cells | B | 7.15 | pIC50 | 70 | nM | IC50 | Bioorg Med Chem Lett (2006) 16: 3564-3568 [PMID:16621543] |
S1P5 receptor/Sphingosine 1-phosphate receptor Edg-8 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2274] [GtoPdb: 279] [UniProtKB: Q9H228] | ||||||||
GtoPdb | - | - | 9 | pIC50 | - | - | - | J Med Chem (2005) 48: 6169-73 [PMID:16190743] |
ChEMBL | Concentration required for displacement of [33P]-labeled S1P from human sphingosine 1-phosphate receptor 5 expressed in CHO cells | B | 9 | pIC50 | 1 | nM | IC50 | J Med Chem (2005) 48: 6169-6173 [PMID:16190743] |
ChEMBL | Displacement of [33P]S1P from human S1P5 receptor expressed in CHO cells | B | 9 | pIC50 | 1 | nM | IC50 | Bioorg Med Chem Lett (2006) 16: 3564-3568 [PMID:16621543] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]