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S1P2 receptor

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Immunopharmacology Ligand target has curated data in GtoImmuPdb

Target id: 276

Nomenclature: S1P2 receptor

Family: Lysophospholipid (S1P) receptors

Gene and Protein Information Click here for help
class A G protein-coupled receptor
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 7 353 19p13.2 S1PR2 sphingosine-1-phosphate receptor 2
Mouse 7 352 9 7.68 cM S1pr2 sphingosine-1-phosphate receptor 2
Rat 7 352 8q13 S1pr2 sphingosine-1-phosphate receptor 2
Previous and Unofficial Names Click here for help
edg5 | Gpcr13 | endothelial differentiation G protein-coupled receptor 5 | G protein-coupled receptor 13 | GPCR18 | S1P receptor 2
Database Links Click here for help
Specialist databases
GPCRdb s1pr2_human (Hs), s1pr2_mouse (Mm), s1pr2_rat (Rn)
Other databases
Alphafold
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
Pharos
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Selected 3D Structures Click here for help
Image of receptor 3D structure from RCSB PDB
Description:  Structure of S1PR2-heterotrimeric G13 signaling complex
PDB Id:  7T6B
Ligand:  sphingosine 1-phosphate
Resolution:  3.19Å
Species:  Human
References:  5
Natural/Endogenous Ligands Click here for help
dihydrosphingosine 1-phosphate
sphingosine 1-phosphate
sphingosylphosphorylcholine
Comments: Sphingosine 1-phosphate exhibits greater potency than sphingosylphosphorylcholine
Potency order of endogenous ligands
sphingosine 1-phosphate > dihydrosphingosine 1-phosphate  [2,29]

Download all structure-activity data for this target as a CSV file go icon to follow link

Agonists
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
sphingosine 1-phosphate Small molecule or natural product Click here for species-specific activity table Ligand is endogenous in the given species Ligand has a PDB structure Hs Agonist 7.6 – 7.7 pKd 19,41
pKd 7.6 – 7.7 (Kd 2.7x10-8 – 2.04x10-8 M) [19,41]
sphingosine 1-phosphate Small molecule or natural product Click here for species-specific activity table Ligand is endogenous in the given species Ligand has a PDB structure Mm Agonist 8.7 pEC50 35
pEC50 8.7 (EC50 2x10-9 M) [35]
sphingosine 1-phosphate Small molecule or natural product Click here for species-specific activity table Ligand is endogenous in the given species Ligand has a PDB structure Hs Agonist 8.1 – 8.5 pEC50 14,33
pEC50 8.1 – 8.5 [14,33]
fingolimod-phosphate Small molecule or natural product Click here for species-specific activity table Hs Agonist 7.5 pEC50 39
pEC50 7.5 (EC50 3.5x10-8 M) Measured using an impedance-based assay system [39]
CYM-5478 Small molecule or natural product Hs Agonist 6.9 pEC50 12
pEC50 6.9 (EC50 1.19x10-7 M) [12]
Description: Determined in a cellular TGFα-shedding assay
CYM5520 Small molecule or natural product Hs Agonist 6.3 pEC50 36
pEC50 6.3 (EC50 4.8x10-7 M) [36]
ozanimod Small molecule or natural product Approved drug Click here for species-specific activity table Ligand has a PDB structure Immunopharmacology Ligand Hs Agonist <5.0 pEC50 37
pEC50 <5.0 (EC50 >1x10-5 M) [37]
Description: In a GTPγS assay.
AUY954 Small molecule or natural product Click here for species-specific activity table Mm Agonist 4.7 – 5.0 pEC50 33
pEC50 4.7 – 5.0 [33]
compound 43 [PMID: 26751273] Small molecule or natural product Click here for species-specific activity table Immunopharmacology Ligand Hs Agonist >4.5 pEC50 6
pEC50 >4.5 (EC50 <3.163x10-5 M) [6]
Description: In a S1P2R yeast reporter assay.
S1P d20:1 Small molecule or natural product Hs Partial agonist - - 42
[42]
View species-specific agonist tables
Antagonists
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
compound 16 [PMID: 26794040] Small molecule or natural product Primary target of this compound Immunopharmacology Ligand Hs Antagonist 8.1 pIC50 23
pIC50 8.1 (IC50 8.2x10-9 M) [23]
JTE-013 Small molecule or natural product Click here for species-specific activity table Hs Antagonist 7.8 pIC50 31
pIC50 7.8 (IC50 1.7x10-8 M) [31]
JTE-013 Small molecule or natural product Rn Antagonist 7.7 – 7.8 pIC50 13,31
pIC50 7.7 – 7.8 (IC50 2.2x10-8 – 1.7x10-8 M) [13,31]
View species-specific antagonist tables
Antagonist Comments
S1P d20:1 is reported to inhibit S1P-inudced COX-2 expression via S1P2 in glioblastoma cell line LN299 [42].
Immunopharmacology Comments
Activation of S1P2R has pro-inflammatory effects (e.g. mast cell degranulation, regulation of pro-inflammatory cytokine production, and cytokine and chemokine release [22,32]. In human cord blood mast cells, S1P2R positively regulates allergen-induced degranulation and chemokine release [30,34].
Cell Type Associations
Immuno Cell Type:  Other T cells
Cell Ontology Term:   memory T cell (CL:0000813)
Comment:  S1P2 signaling is chemorepulsive to T central memory and T resident memory cells in vitro.
References:  7
Immuno Cell Type:  Mast cells
Cell Ontology Term:   mast cell (CL:0000097)
Comment:  Cord blood mast cells express S1P1R and S1P2R
References:  24
Immuno Cell Type:  B cells
Comment:  Germinal center B cells utilize S1P2 signaling to regulate survival, proliferation. and niche confinement.
References:  9
Primary Transduction Mechanisms Click here for help
Transducer Effector/Response
Gs family
Gq/G11 family
G12/G13 family
Adenylyl cyclase stimulation
Phospholipase C stimulation
Calcium channel
Comments:  Activation of Rho, MAPK, and phosphorylation of MLC [8].
References:  8,17
Tissue Distribution Click here for help
Embryonic brain
Expression level:  High
Species:  Mouse
Technique:  RT-PCR, Northern hybridization analysis
References:  26-27,44
Adult heart, lung
Expression level:  High
Species:  Mouse
Technique:  Northern blot analysis
References:  43
Heart, lung, kidney, liver, and thymus
Species:  Mouse
Technique:  Northern blot
References:  44
Expression Datasets Click here for help

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Log average relative transcript abundance in mouse tissues measured by qPCR from Regard, J.B., Sato, I.T., and Coughlin, S.R. (2008). Anatomical profiling of G protein-coupled receptor expression. Cell, 135(3): 561-71. [PMID:18984166] [Raw data: website]

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Functional Assays Click here for help
Cell proliferation and survival
Species:  Human
Tissue:  HTC4 hepatoma cells stably transfected with human S1P2
Response measured: 
References:  1
Negative regulation of cell motility
Species:  Mouse
Tissue:  B16 melanoma cell
Response measured: 
References:  3
Negative regulation of endothelial morphogenesis and angiogenesis
Species:  Mouse
Tissue:  Vascular endothelial cells
Response measured: 
References:  15
Physiological Consequences of Altering Gene Expression Click here for help
Eyelid closure during embryonic development in S1P2/S1P3 double knockout mice
Species:  Mouse
Tissue: 
Technique:  Gene knockout
References:  11
Deafness and stria vascularis defects
Species:  Mouse
Tissue: 
Technique:  Gene knockout
References:  10,20,25
No gross anatomical abnormalities, but spontaneous seizures (3 – 7 weeks of age) and neuronal hyperexcitability
Species:  Mouse
Tissue: 
Technique:  Gene targeting (replacement vector with LacZ marker gene, deletion of entire ORF)
References:  27
Slightly reduced viability; normal development and fertility
Species:  Mouse
Tissue: 
Technique:  Gene knockout
References:  16
Loss of phagocytic activity in receptor knockout macrophages
Species:  Mouse
Tissue: 
Technique:  Gene knockout
References:  28
Suppression of vasoconstriction in knockout mice
Species:  Mouse
Tissue: 
Technique:  Gene knockout
References:  40
Development of clonal B-cell lymphomas with age in knockout mice
Species:  Mouse
Tissue: 
Technique:  Gene knockout
References:  4
Suppression of pathologic neovascularization in knockout mice
Species:  Mouse
Tissue: 
Technique:  Gene knockout
References:  38
Severe vascular phenotype in S1P2/S1P3 double and S1P1/S1P2/S1P3 triple knockout mice
Species:  Mouse
Tissue: 
Technique:  Gene knockout
References:  21
Phenotypes, Alleles and Disease Models Click here for help Mouse data from MGI

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Allele Composition & genetic background Accession Phenotype Id Phenotype Reference
S1pr2tm1Ajml S1pr2tm1Ajml/S1pr2tm1Ajml
involves: 129S5/SvEvBrd * C57BL/6
MGI:99569  MP:0005402 abnormal action potential PMID: 11553273 
S1pr1tm1Rlp|S1pr2tm1Rlp S1pr1tm1Rlp/S1pr1tm1Rlp,S1pr2tm1Rlp/S1pr2tm1Rlp
involves: 129S6/SvEvTac * C57BL/6
MGI:1096355  MGI:99569  MP:0000260 abnormal angiogenesis PMID: 15138255 
S1pr1tm1Rlp|S1pr2tm1Rlp|S1pr3tm1Rlp S1pr1tm1Rlp/S1pr1tm1Rlp,S1pr3tm1Rlp/S1pr3tm1Rlp,S1pr2tm1Rlp/S1pr2tm1Rlp
involves: 129S6/SvEvTac * C57BL/6
MGI:1096355  MGI:1339365  MGI:99569  MP:0000260 abnormal angiogenesis PMID: 15138255 
S1pr2tm1Ajml S1pr2tm1Ajml/S1pr2tm1Ajml
involves: 129S5/SvEvBrd * C57BL/6
MGI:99569  MP:0004994 abnormal brain wave pattern PMID: 11553273 
S1pr2tm1Ajml S1pr2tm1Ajml/S1pr2tm1Ajml
involves: 129S5/SvEvBrd * C57BL/6
MGI:99569  MP:0002206 abnormal CNS synaptic transmission PMID: 11553273 
S1pr2tm1Ajml S1pr2tm1Ajml/S1pr2tm1Ajml
involves: 129S5/SvEvBrd * C57BL/6
MGI:99569  MP:0002910 abnormal excitatory postsynaptic currents PMID: 11553273 
S1pr2tm1Jch|S1pr3tm1Jch S1pr2tm1Jch/S1pr2tm1Jch,S1pr3tm1Jch/S1pr3tm1Jch
involves: 129S1/Sv * 129X1/SvJ * C57BL/6N
MGI:1339365  MGI:99569  MP:0001386 abnormal maternal nurturing PMID: 12006579 
S1pr2tm1Ajml S1pr2tm1Ajml/S1pr2tm1Ajml
involves: 129S5/SvEvBrd * C57BL/6
MGI:99569  MP:0002272 abnormal nervous system electrophysiology PMID: 11553273 
S1pr2tm1Jch|S1pr3tm1Jch S1pr2tm1Jch/S1pr2tm1Jch,S1pr3tm1Jch/S1pr3tm1Jch
involves: 129S1/Sv * 129X1/SvJ * C57BL/6N
MGI:1339365  MGI:99569  MP:0001504 abnormal posture PMID: 17287522 
S1pr2tm1Ajml S1pr2tm1Ajml/S1pr2tm1Ajml
either: (involves: 129S5/SvEvBrd) or (involves: 129S5/SvEvBrd * C57BL/6)
MGI:99569  MP:0004305 abnormal Rosenthal canal morphology PMID: 16945494 
S1pr2tm1Rlp|S1pr3tm1Rlp S1pr3tm1Rlp/S1pr3tm1Rlp,S1pr2tm1Rlp/S1pr2tm1Rlp
involves: 129S6/SvEvTac * C57BL/6
MGI:1339365  MGI:99569  MP:0004244 abnormal spontaneous abortion rate PMID: 15138255 
S1pr2tm1Rlp S1pr2tm1Rlp/S1pr2tm1Rlp
involves: 129S6/SvEvTac * C57BL/6
MGI:99569  MP:0004365 abnormal strial basal cells PMID: 17284444 
S1pr2tm1Rlp S1pr2tm1Rlp/S1pr2tm1Rlp
involves: 129S6/SvEvTac * C57BL/6
MGI:99569  MP:0004367 abnormal strial intermediate cells PMID: 17284444 
S1pr2tm1Rlp S1pr2tm1Rlp/S1pr2tm1Rlp
involves: 129S6/SvEvTac * C57BL/6
MGI:99569  MP:0004366 abnormal strial marginal cells PMID: 17284444 
S1pr2tm1Rlp S1pr2tm1Rlp/S1pr2tm1Rlp
involves: 129S6/SvEvTac * C57BL/6
MGI:99569  MP:0000048 abnormal stria vascularis PMID: 17284444 
S1pr2tm1Rlp S1pr2tm1Rlp/S1pr2tm1Rlp
involves: 129S6/SvEvTac * C57BL/6
MGI:99569  MP:0004368 abnormal stria vascularis vasculature morphology PMID: 17284444 
S1pr2tm1Ajml S1pr2tm1Ajml/S1pr2tm1Ajml
either: (involves: 129S5/SvEvBrd) or (involves: 129S5/SvEvBrd * C57BL/6)
MGI:99569  MP:0003149 abnormal tectorial membrane morphology PMID: 16945494 
S1pr2tm1Rlp|S1pr3tm1Rlp S1pr3tm1Rlp/S1pr3tm1Rlp,S1pr2tm1Rlp/S1pr2tm1Rlp
involves: 129S6/SvEvTac * C57BL/6
MGI:1339365  MGI:99569  MP:0006055 abnormal vascular endothelial cell morphology PMID: 15138255 
S1pr2tm1Rlp S1pr2tm1Rlp/S1pr2tm1Rlp
involves: 129S6/SvEvTac * C57BL/6
MGI:99569  MP:0004427 abnormal vestibular labyrinth PMID: 17284444 
S1pr2tm1Jch|S1pr3tm1Jch S1pr2tm1Jch/S1pr2tm1Jch,S1pr3tm1Jch/S1pr3tm1Jch
involves: 129S1/Sv * 129X1/SvJ * C57BL/6N
MGI:1339365  MGI:99569  MP:0004742 abnormal vestibular system physiology PMID: 17287522 
S1pr2tm1Ajml S1pr2tm1Ajml/S1pr2tm1Ajml
either: (involves: 129S5/SvEvBrd) or (involves: 129S5/SvEvBrd * C57BL/6)
MGI:99569  MP:0004742 abnormal vestibular system physiology PMID: 16945494 
S1pr2tm1Jch|S1pr3tm1Jch S1pr2tm1Jch/S1pr2tm1Jch,S1pr3tm1Jch/S1pr3tm1Jch
involves: 129S1/Sv * 129X1/SvJ * C57BL/6N
MGI:1339365  MGI:99569  MP:0000034 abnormal vestibule morphology PMID: 17287522 
S1pr2tm1Rlp S1pr2tm1Rlp/S1pr2tm1Rlp
involves: 129S6/SvEvTac * C57BL/6
MGI:99569  MP:0004763 absent brainstem auditory evoked potential PMID: 17284444 
S1pr2tm1Ajml S1pr2tm1Ajml/S1pr2tm1Ajml
either: (involves: 129S5/SvEvBrd) or (involves: 129S5/SvEvBrd * C57BL/6)
MGI:99569  MP:0004763 absent brainstem auditory evoked potential PMID: 16945494 
S1pr2tm1Rlp S1pr2tm1Rlp/S1pr2tm1Rlp
involves: 129S6/SvEvTac * C57BL/6
MGI:99569  MP:0004737 absent distortion product otoacoustic emissions PMID: 17284444 
S1pr2tm1Jch S1pr2tm1Jch/S1pr2tm1Jch
involves: 129S1/Sv * 129X1/SvJ * C57BL/6N
MGI:99569  MP:0006359 absent startle reflex PMID: 17287522 
S1pr2tm1Jch|S1pr3tm1Jch S1pr2tm1Jch/S1pr2tm1Jch,S1pr3tm1Jch/S1pr3tm1Jch
involves: 129S1/Sv * 129X1/SvJ * C57BL/6N
MGI:1339365  MGI:99569  MP:0006359 absent startle reflex PMID: 17287522 
S1pr2tm1Jch|S1pr3+|S1pr3tm1Jch S1pr3tm1Jch/S1pr3+,S1pr2tm1Jch/S1pr2tm1Jch
involves: 129S1/Sv * 129X1/SvJ * C57BL/6N
MGI:1339365  MGI:99569  MP:0006359 absent startle reflex PMID: 17287522 
S1pr2tm1Jch|S1pr3tm1Jch S1pr2tm1Jch/S1pr2tm1Jch,S1pr3tm1Jch/S1pr3tm1Jch
involves: 129S1/Sv * 129X1/SvJ * C57BL/6N
MGI:1339365  MGI:99569  MP:0004518 absent vestibular hair cell stereocilia PMID: 17287522 
S1pr2tm1Rlp|S1pr3tm1Rlp S1pr3tm1Rlp/S1pr3tm1Rlp,S1pr2tm1Rlp/S1pr2tm1Rlp
involves: 129S6/SvEvTac * C57BL/6
MGI:1339365  MGI:99569  MP:0002857 cochlear ganglion degeneration PMID: 17284444 
S1pr2tm1Rlp S1pr2tm1Rlp/S1pr2tm1Rlp
involves: 129S6/SvEvTac * C57BL/6
MGI:99569  MP:0002857 cochlear ganglion degeneration PMID: 17284444 
S1pr2tm1Jch|S1pr3tm1Jch S1pr2tm1Jch/S1pr2tm1Jch,S1pr3tm1Jch/S1pr3tm1Jch
involves: 129S1/Sv * 129X1/SvJ * C57BL/6N
MGI:1339365  MGI:99569  MP:0002857 cochlear ganglion degeneration PMID: 17287522 
S1pr2tm1Rlp S1pr2tm1Rlp/S1pr2tm1Rlp
involves: 129S6/SvEvTac * C57BL/6
MGI:99569  MP:0004362 cochlear hair cell degeneration PMID: 17284444 
S1pr2tm1Jch|S1pr3tm1Jch S1pr2tm1Jch/S1pr2tm1Jch,S1pr3tm1Jch/S1pr3tm1Jch
involves: 129S1/Sv * 129X1/SvJ * C57BL/6N
MGI:1339365  MGI:99569  MP:0004398 cochlear inner hair cell degeneration PMID: 17287522 
S1pr2tm1Jch|S1pr3tm1Jch S1pr2tm1Jch/S1pr2tm1Jch,S1pr3tm1Jch/S1pr3tm1Jch
involves: 129S1/Sv * 129X1/SvJ * C57BL/6N
MGI:1339365  MGI:99569  MP:0004404 cochlear outer hair cell degeneration PMID: 17287522 
S1pr2tm1Ajml S1pr2tm1Ajml/S1pr2tm1Ajml
either: (involves: 129S5/SvEvBrd) or (involves: 129S5/SvEvBrd * C57BL/6)
MGI:99569  MP:0004404 cochlear outer hair cell degeneration PMID: 16945494 
S1pr2tm1Rlp S1pr2tm1Rlp/S1pr2tm1Rlp
involves: 129S6/SvEvTac * C57BL/6
MGI:99569  MP:0001967 deafness PMID: 17284444 
S1pr2tm1Ajml S1pr2tm1Ajml/S1pr2tm1Ajml
either: (involves: 129S5/SvEvBrd) or (involves: 129S5/SvEvBrd * C57BL/6)
MGI:99569  MP:0001967 deafness PMID: 16945494 
S1pr2tm1Jch S1pr2tm1Jch/S1pr2tm1Jch
involves: 129S1/Sv * 129X1/SvJ * C57BL/6N
MGI:99569  MP:0001935 decreased litter size PMID: 12006579 
S1pr2tm1Jch|S1pr3tm1Jch S1pr2tm1Jch/S1pr2tm1Jch,S1pr3tm1Jch/S1pr3tm1Jch
involves: 129S1/Sv * 129X1/SvJ * C57BL/6N
MGI:1339365  MGI:99569  MP:0001935 decreased litter size PMID: 12006579 
S1pr2tm1Rlp S1pr2tm1Rlp/S1pr2tm1Rlp
involves: 129S6/SvEvTac * C57BL/6
MGI:99569  MP:0003144 decreased otolith number PMID: 17284444 
S1pr2tm1Ajml S1pr2tm1Ajml/S1pr2tm1Ajml
either: (involves: 129S5/SvEvBrd) or (involves: 129S5/SvEvBrd * C57BL/6)
MGI:99569  MP:0003144 decreased otolith number PMID: 16945494 
S1pr2tm1Jch|S1pr3tm1Jch S1pr2tm1Jch/S1pr2tm1Jch,S1pr3tm1Jch/S1pr3tm1Jch
involves: 129S1/Sv * 129X1/SvJ * C57BL/6N
MGI:1339365  MGI:99569  MP:0002757 decreased vertical activity PMID: 17287522 
S1pr2tm1Jch|S1pr3tm1Jch S1pr2tm1Jch/S1pr2tm1Jch,S1pr3tm1Jch/S1pr3tm1Jch
involves: 129S1/Sv * 129X1/SvJ * C57BL/6N
MGI:1339365  MGI:99569  MP:0004465 degeneration of organ of Corti supporting cells PMID: 17287522 
S1pr2tm1Ajml S1pr2tm1Ajml/S1pr2tm1Ajml
either: (involves: 129S5/SvEvBrd) or (involves: 129S5/SvEvBrd * C57BL/6)
MGI:99569  MP:0006023 detached Reissner membrane PMID: 16945494 
S1pr1tm1Rlp|S1pr2tm1Rlp S1pr1tm1Rlp/S1pr1tm1Rlp,S1pr2tm1Rlp/S1pr2tm1Rlp
involves: 129S6/SvEvTac * C57BL/6
MGI:1096355  MGI:99569  MP:0006207 embryonic lethality during organogenesis PMID: 15138255 
S1pr1tm1Rlp|S1pr2tm1Rlp|S1pr3tm1Rlp S1pr1tm1Rlp/S1pr1tm1Rlp,S1pr3tm1Rlp/S1pr3tm1Rlp,S1pr2tm1Rlp/S1pr2tm1Rlp
involves: 129S6/SvEvTac * C57BL/6
MGI:1096355  MGI:1339365  MGI:99569  MP:0006207 embryonic lethality during organogenesis PMID: 15138255 
S1pr2tm1Rlp S1pr2tm1Rlp/S1pr2tm1Rlp
involves: 129S6/SvEvTac * C57BL/6
MGI:99569  MP:0003143 enlarged otoliths PMID: 17284444 
S1pr2tm1Rlp|S1pr3tm1Rlp S1pr3tm1Rlp/S1pr3tm1Rlp,S1pr2tm1Rlp/S1pr2tm1Rlp
involves: 129S6/SvEvTac * C57BL/6
MGI:1339365  MGI:99569  MP:0005191 head tilt PMID: 17284444 
S1pr2tm1Rlp S1pr2tm1Rlp/S1pr2tm1Rlp
involves: 129S6/SvEvTac * C57BL/6
MGI:99569  MP:0005191 head tilt PMID: 17284444 
S1pr2tm1Jch|S1pr3tm1Jch S1pr2tm1Jch/S1pr2tm1Jch,S1pr3tm1Jch/S1pr3tm1Jch
involves: 129S1/Sv * 129X1/SvJ * C57BL/6N
MGI:1339365  MGI:99569  MP:0005191 head tilt PMID: 17287522 
S1pr2tm1Ajml S1pr2tm1Ajml/S1pr2tm1Ajml
either: (involves: 129S5/SvEvBrd) or (involves: 129S5/SvEvBrd * C57BL/6)
MGI:99569  MP:0005191 head tilt PMID: 16945494 
S1pr2tm1Rlp|S1pr3tm1Rlp S1pr3tm1Rlp/S1pr3tm1Rlp,S1pr2tm1Rlp/S1pr2tm1Rlp
involves: 129S6/SvEvTac * C57BL/6
MGI:1339365  MGI:99569  MP:0001914 hemorrhage PMID: 15138255 
S1pr1tm1Rlp|S1pr2tm1Rlp S1pr1tm1Rlp/S1pr1tm1Rlp,S1pr2tm1Rlp/S1pr2tm1Rlp
involves: 129S6/SvEvTac * C57BL/6
MGI:1096355  MGI:99569  MP:0001914 hemorrhage PMID: 15138255 
S1pr1tm1Rlp|S1pr2tm1Rlp|S1pr3tm1Rlp S1pr1tm1Rlp/S1pr1tm1Rlp,S1pr3tm1Rlp/S1pr3tm1Rlp,S1pr2tm1Rlp/S1pr2tm1Rlp
involves: 129S6/SvEvTac * C57BL/6
MGI:1096355  MGI:1339365  MGI:99569  MP:0001914 hemorrhage PMID: 15138255 
S1pr2tm1Jch|S1pr3tm1Jch S1pr2tm1Jch/S1pr2tm1Jch,S1pr3tm1Jch/S1pr3tm1Jch
involves: 129S1/Sv * 129X1/SvJ * C57BL/6N
MGI:1339365  MGI:99569  MP:0001523 impaired righting response PMID: 17287522 
S1pr2tm1Jch|S1pr3tm1Jch S1pr2tm1Jch/S1pr2tm1Jch,S1pr3tm1Jch/S1pr3tm1Jch
involves: 129S1/Sv * 129X1/SvJ * C57BL/6N
MGI:1339365  MGI:99569  MP:0001522 impaired swimming PMID: 17287522 
S1pr2tm1Ajml S1pr2tm1Ajml/S1pr2tm1Ajml
either: (involves: 129S5/SvEvBrd) or (involves: 129S5/SvEvBrd * C57BL/6)
MGI:99569  MP:0001522 impaired swimming PMID: 16945494 
S1pr2tm1Jch|S1pr3tm1Jch S1pr2tm1Jch/S1pr2tm1Jch,S1pr3tm1Jch/S1pr3tm1Jch
involves: 129S1/Sv * 129X1/SvJ * C57BL/6N
MGI:1339365  MGI:99569  MP:0001513 limb grasping PMID: 17287522 
S1pr2tm1Rlp S1pr2tm1Rlp/S1pr2tm1Rlp
involves: 129S6/SvEvTac * C57BL/6
MGI:99569  MP:0000043 organ of Corti degeneration PMID: 17284444 
S1pr2tm1Jch|S1pr3tm1Jch S1pr2tm1Jch/S1pr2tm1Jch,S1pr3tm1Jch/S1pr3tm1Jch
involves: 129S1/Sv * 129X1/SvJ * C57BL/6N
MGI:1339365  MGI:99569  MP:0000043 organ of Corti degeneration PMID: 17287522 
S1pr2tm1Ajml S1pr2tm1Ajml/S1pr2tm1Ajml
either: (involves: 129S5/SvEvBrd) or (involves: 129S5/SvEvBrd * C57BL/6)
MGI:99569  MP:0000043 organ of Corti degeneration PMID: 16945494 
S1pr2tm1Ajml S1pr2tm1Ajml/S1pr2tm1Ajml
either: (involves: 129S5/SvEvBrd) or (involves: 129S5/SvEvBrd * C57BL/6)
MGI:99569  MP:0004897 otosclerosis PMID: 16945494 
S1pr2tm1Jch|S1pr3tm1Jch S1pr2tm1Jch/S1pr2tm1Jch,S1pr3tm1Jch/S1pr3tm1Jch
involves: 129S1/Sv * 129X1/SvJ * C57BL/6N
MGI:1339365  MGI:99569  MP:0002081 perinatal lethality PMID: 12006579 
S1pr2tm1Ajml S1pr2tm1Ajml/S1pr2tm1Ajml
either: (involves: 129S5/SvEvBrd) or (involves: 129S5/SvEvBrd * C57BL/6)
MGI:99569  MP:0002083 premature death PMID: 16945494 
S1pr2tm1Rlp|S1pr3tm1Rlp S1pr3tm1Rlp/S1pr3tm1Rlp,S1pr2tm1Rlp/S1pr2tm1Rlp
involves: 129S6/SvEvTac * C57BL/6
MGI:1339365  MGI:99569  MP:0002080 prenatal lethality PMID: 15138255  17284444 
S1pr2tm1Rlp|S1pr3tm1Rlp S1pr3tm1Rlp/S1pr3tm1Rlp,S1pr2tm1Rlp/S1pr2tm1Rlp
involves: 129S6/SvEvTac * C57BL/6
MGI:1339365  MGI:99569  MP:0001921 reduced fertility PMID: 15138255 
S1pr2tm1Ajml S1pr2tm1Ajml/S1pr2tm1Ajml
either: (involves: 129S5/SvEvBrd) or (involves: 129S5/SvEvBrd * C57BL/6)
MGI:99569  MP:0004329 saccular degeneration PMID: 16945494 
S1pr2tm1Jch|S1pr3tm1Jch S1pr2tm1Jch/S1pr2tm1Jch,S1pr3tm1Jch/S1pr3tm1Jch
involves: 129S1/Sv * 129X1/SvJ * C57BL/6N
MGI:1339365  MGI:99569  MP:0004331 saccular macula degeneration PMID: 17287522 
S1pr2tm1Ajml S1pr2tm1Ajml/S1pr2tm1Ajml
involves: 129S5/SvEvBrd * C57BL/6
MGI:99569  MP:0002064 seizures PMID: 11553273 
S1pr2tm1Ajml S1pr2tm1Ajml/S1pr2tm1Ajml
either: (involves: 129S5/SvEvBrd) or (involves: 129S5/SvEvBrd * C57BL/6)
MGI:99569  MP:0002064 seizures PMID: 16945494 
S1pr2tm1Rlp|S1pr3tm1Rlp S1pr3tm1Rlp/S1pr3tm1Rlp,S1pr2tm1Rlp/S1pr2tm1Rlp
involves: 129S6/SvEvTac * C57BL/6
MGI:1339365  MGI:99569  MP:0001786 skin edema PMID: 15138255 
S1pr2tm1Ajml S1pr2tm1Ajml/S1pr2tm1Ajml
either: (involves: 129S5/SvEvBrd) or (involves: 129S5/SvEvBrd * C57BL/6)
MGI:99569  MP:0008308 small scala media PMID: 16945494 
S1pr2tm1Ajml S1pr2tm1Ajml/S1pr2tm1Ajml
either: (involves: 129S5/SvEvBrd) or (involves: 129S5/SvEvBrd * C57BL/6)
MGI:99569  MP:0004364 thin stria vascularis PMID: 16945494 
S1pr2tm1Ajml S1pr2tm1Ajml/S1pr2tm1Ajml
involves: 129S5/SvEvBrd * C57BL/6
MGI:99569  MP:0003997 tonic-clonic seizures PMID: 11553273 
S1pr2tm1Jch|S1pr3tm1Jch S1pr2tm1Jch/S1pr2tm1Jch,S1pr3tm1Jch/S1pr3tm1Jch
involves: 129S1/Sv * 129X1/SvJ * C57BL/6N
MGI:1339365  MGI:99569  MP:0004334 utricular macular degeneration PMID: 17287522 
S1pr2tm1Jch|S1pr3tm1Jch S1pr2tm1Jch/S1pr2tm1Jch,S1pr3tm1Jch/S1pr3tm1Jch
involves: 129S1/Sv * 129X1/SvJ * C57BL/6N
MGI:1339365  MGI:99569  MP:0004324 vestibular hair cell degeneration PMID: 17287522 
General Comments
S1P2 receptor has been shown to be a specific receptor for the central nervous system membrane protein Nogo-A-Δ20 [18].

References

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