ZD6021 [Ligand Id: 2109] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL129683 (ZD-6021) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| NK1 receptor/Neurokinin 1 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL249] [GtoPdb: 360] [UniProtKB: P25103] | ||||||||
| ChEMBL | Inhibition of binding of [3H]SP to Tachykinin receptor 1 of human tachykinin receptor expressed in mouse erythroleukemia cells | B | 9.92 | pKi | 0.12 | nM | Ki | J Med Chem (2002) 45: 3972-3983 [PMID:12190319] |
| ChEMBL | Binding affinity against human cloned Tachykinin receptor 1 expressed in MEL cells | B | 10 | pKi | 0.1 | nM | Ki | Bioorg Med Chem Lett (2001) 11: 2769-2773 [PMID:11591520] |
| GtoPdb | - | - | 9.9 | pIC50 | - | - | - | J Pharmacol Exp Ther (2001) 298: 307-15 [PMID:11408556] |
| NK2 receptor/Neurokinin 2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2327] [GtoPdb: 361] [UniProtKB: P21452] | ||||||||
| ChEMBL | Inhibition of binding of [3H]NKA to human Tachykinin receptor 2 (NK2) expressed in mouse erythroleukemia cells | B | 9.19 | pKi | 0.64 | nM | Ki | J Med Chem (2002) 45: 3972-3983 [PMID:12190319] |
| ChEMBL | Binding affinity against human cloned Tachykinin receptor 2 expressed in MEL cells | B | 9.22 | pKi | 0.6 | nM | Ki | Bioorg Med Chem Lett (2001) 11: 2769-2773 [PMID:11591520] |
| NK3 receptor/Neurokinin 3 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4429] [GtoPdb: 362] [UniProtKB: P29371] | ||||||||
| ChEMBL | Binding affinity against human cloned Tachykinin receptor 3 expressed in MEL cells | B | 7.13 | pKi | 74 | nM | Ki | Bioorg Med Chem Lett (2001) 11: 2769-2773 [PMID:11591520] |
| ChEMBL | Inhibition of binding of [125I]MPNI to human Tachykinin receptor 3 (NK3) expressed in mouse erythroleukemia cells | B | 7.13 | pKi | 74 | nM | Ki | J Med Chem (2002) 45: 3972-3983 [PMID:12190319] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
