ChEMBL ligand: CHEMBL382301 (Antocile, Antocin, Antocin ii, Atosiban, CAP-449, CAP-476, CAP-581, F-314, ORF 22164, ORF-22164, RW-22164, RWJ 22164, RWJ-22164, Tractocil, Tractocile)
OT receptor/Oxytocin receptor in Human [ChEMBL: CHEMBL2049] [GtoPdb: 369] [UniProtKB: P30559] OT receptor/Oxytocin receptor in Rat [ChEMBL: CHEMBL3996] [GtoPdb: 369] [UniProtKB: P70536] There should be some charts here, you may need to enable JavaScript!
V1A receptor/Vasopressin V1a receptor in Human [ChEMBL: CHEMBL1889] [GtoPdb: 366] [UniProtKB: P37288] There should be some charts here, you may need to enable JavaScript!
V1B receptor/Vasopressin V1b receptor in Human [ChEMBL: CHEMBL1921] [GtoPdb: 367] [UniProtKB: P47901] There should be some charts here, you may need to enable JavaScript!
V2 receptor/Vasopressin V2 receptor in Human [ChEMBL: CHEMBL1790] [GtoPdb: 368] [UniProtKB: P30518] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
OT receptor/Oxytocin receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2049] [GtoPdb: 369] [UniProtKB: P30559]
ChEMBL	Binding affinity to oxytocin receptor	B	6.4	pKi	397	nM	Ki	Bioorg. Med. Chem. Lett. (2009) 19: 990-994 [PMID:19095447]
ChEMBL	Displacement of [3H]oxytocin from human OTR	B	7.4	pKi	39.81	nM	Ki	J. Med. Chem. (2006) 49: 4159-4170 [PMID:16821776]
ChEMBL	Binding affinity to recombinant oxytocin receptor	B	7.49	pKi	32	nM	Ki	Bioorg. Med. Chem. Lett. (2008) 18: 90-94 [PMID:18032036]
ChEMBL	Displacement of [125I]OVTA antagonist from human oxytocin receptor expressed in HEK293-EBNA cells	B	7.57	pKi	27	nM	Ki	J. Med. Chem. (2005) 48: 7882-7905 [PMID:16302826]
GtoPdb	-	-	7.6	pKi	-	-	-	Br J Obstet Gynaecol (1999) 106: 1047-53 [PMID:10519430]; J Pharmacol Exp Ther (2003) 306: 253-61 [PMID:12660315]; J Pharmacol Exp Therap (2004) 309: 414-424 [PMID:14722330]; J Pept Sci (2005) 11: 593-608 [PMID:15880385]; Life Sci (1995) 57: 2253-61 [PMID:7475979]
ChEMBL	Binding affinity to human oxytocin receptor	B	7.96	pKi	11	nM	Ki	Bioorg. Med. Chem. Lett. (2008) 18: 90-94 [PMID:18032036]
ChEMBL	Antagonist activity at human OTR expressed in HEK293 cell membranes assessed as inhibition of OT-induced IP1 accumulation measured after 1 hr by fluorescence assay	F	6.43	pIC50	372	nM	IC50	Eur J Med Chem (2017) 136: 330-333 [PMID:28505537]
ChEMBL	Inhibitory activity against human Oxytocin induced intracellular Calcium mobilization in human Oxytocin receptor transfected HEK293-EBNA cells	F	7.23	pIC50	59	nM	IC50	J. Med. Chem. (2005) 48: 7882-7905 [PMID:16302826]
OT receptor/Oxytocin receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3996] [GtoPdb: 369] [UniProtKB: P70536]
ChEMBL	Antagonist activity in rat uterus by uterotonic assay	F	8.29	pKd	5.13	nM	Kd	Eur. J. Med. Chem. (2007) 42: 799-806 [PMID:17316912]
GtoPdb	-	-	7.1	pKi	-	-	-	J Pharmacol Exp Ther (2003) 306: 253-61 [PMID:12660315]
ChEMBL	Displacement of [125I]OVTA antagonist from rat oxytocin receptor expressed in HEK293-EBNA cells	B	7.12	pKi	76	nM	Ki	J. Med. Chem. (2005) 48: 7882-7905 [PMID:16302826]
ChEMBL	Displacement of [3H]oxytocin from rat OTR	B	7.4	pKi	39.81	nM	Ki	J. Med. Chem. (2006) 49: 4159-4170 [PMID:16821776]
ChEMBL	Antagonism of OT-induced response at OT receptor in rat uterine strips	F	7.92	pIC50	12	nM	IC50	Bioorg. Med. Chem. Lett. (2006) 16: 954-959 [PMID:16297621]
V1A receptor/Vasopressin V1a receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1889] [GtoPdb: 366] [UniProtKB: P37288]
ChEMBL	Binding affinity to vasopressin V1a receptor	B	8.33	pKi	4.7	nM	Ki	Bioorg. Med. Chem. Lett. (2009) 19: 990-994 [PMID:19095447]
GtoPdb	-	-	8.5	pKi	-	-	-	Br J Obstet Gynaecol (1999) 106: 1047-53 [PMID:10519430]; J Pharmacol Exp Ther (2003) 306: 253-61 [PMID:12660315]; J Pharmacol Exp Therap (2004) 309: 414-424 [PMID:14722330]; J Pept Sci (2005) 11: 593-608 [PMID:15880385]
ChEMBL	Displacement of [125I]LVA antagonist from human vasopressin 1a receptor expressed in HEK293-EBNA cells	B	9.2	pKi	0.63	nM	Ki	J. Med. Chem. (2005) 48: 7882-7905 [PMID:16302826]
ChEMBL	Binding affinity to human vasopressin V1a receptor	B	9.82	pKi	0.15	nM	Ki	Bioorg. Med. Chem. Lett. (2008) 18: 90-94 [PMID:18032036]
V1B receptor/Vasopressin V1b receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1921] [GtoPdb: 367] [UniProtKB: P47901]
GtoPdb	-	-	6.6	pKi	-	-	-	J Pharmacol Exp Ther (2003) 306: 253-61 [PMID:12660315]; J Pharmacol Exp Therap (2004) 309: 414-424 [PMID:14722330]
ChEMBL	Binding affinity to human vasopressin V1b receptor	B	7.36	pKi	44	nM	Ki	Bioorg. Med. Chem. Lett. (2008) 18: 90-94 [PMID:18032036]
V2 receptor/Vasopressin V2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1790] [GtoPdb: 368] [UniProtKB: P30518]
GtoPdb	-	-	6	pKi	-	-	-	J Pharmacol Exp Ther (2003) 306: 253-61 [PMID:12660315]; J Pharmacol Exp Therap (2004) 309: 414-424 [PMID:14722330]
ChEMBL	Binding affinity to human vasopressin V2 receptor	B	6.48	pKi	330	nM	Ki	Bioorg. Med. Chem. Lett. (2008) 18: 90-94 [PMID:18032036]

ChEMBL data shown on this page come from version 31:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]