atosiban   

GtoPdb Ligand ID: 2213

Synonyms: Antocin® | d[D-Tyr(Et)2,Thr4,Orn8]vasotocin | d[D-Tyr(Et)2,Thr4]OVT | ORF22164 | RWJ 22164 | Tractocile®
atosiban is an approved drug (EMA (2000))
Comment: A synthetic analogue of oxytocin. There is some ambiguity over the exact stereochemistry of atosiban. Another representation is CID 68613.
2D Structure
Click here for structure editor
SMILES / InChI / InChIKey
Canonical SMILES NCCCC(C(=O)NCC(=O)N)NC(=O)C1CCCN1C(=O)C1CSSCCC(=O)NC(Cc2ccc(cc2)OCC)C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N1)CC(=O)N)C(O)C)C(CC)C
Isomeric SMILES NCCC[C@@H](C(=O)NCC(=O)N)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@H](Cc2ccc(cc2)OCC)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CC(=O)N)[C@H](O)C)[C@H](CC)C
InChI InChI=1S/C43H67N11O12S2/c1-5-23(3)35-41(63)53-36(24(4)55)42(64)50-29(20-32(45)56)38(60)51-30(43(65)54-17-8-10-31(54)40(62)49-27(9-7-16-44)37(59)47-21-33(46)57)22-68-67-18-15-34(58)48-28(39(61)52-35)19-25-11-13-26(14-12-25)66-6-2/h11-14,23-24,27-31,35-36,55H,5-10,15-22,44H2,1-4H3,(H2,45,56)(H2,46,57)(H,47,59)(H,48,58)(H,49,62)(H,50,64)(H,51,60)(H,52,61)(H,53,63)/t23-,24+,27-,28+,29-,30-,31-,35-,36-/m0/s1
InChI Key VWXRQYYUEIYXCZ-OBIMUBPZSA-N
Classification
Compound class Peptide or derivative
Approved drug? Yes (EMA (2000))
IUPAC Name
(2S)-N-[(2S)-5-amino-1-[(2-amino-2-oxoethyl)amino]-1-oxopentan-2-yl]-1-[(4R,7S,10S,13S,16R)-7-(2-amino-2-oxoethyl)-13-[(2S)-butan-2-yl]-16-[(4-ethoxyphenyl)methyl]-10-(1-hydroxyethyl)-6,9,12,15,18-pentaoxo1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carbonyl]pyrrolidine-2-carboxamide
International Nonproprietary Names
INN number INN
6392 atosiban
Synonyms
Antocin® | d[D-Tyr(Et)2,Thr4,Orn8]vasotocin | d[D-Tyr(Et)2,Thr4]OVT | ORF22164 | RWJ 22164 | Tractocile®
Database Links
CAS Registry No. 90779-69-4 (source: Scifinder)
ChEMBL Ligand CHEMBL382301
DrugCentral Ligand 3008
GtoPdb PubChem SID 135652002
PubChem CID 5311010
Search Google for chemical match using the InChIKey VWXRQYYUEIYXCZ-OBIMUBPZSA-N
Search Google for chemicals with the same backbone VWXRQYYUEIYXCZ
Search PubMed clinical trials atosiban
Search PubMed titles atosiban
Search PubMed titles/abstracts atosiban
Search UniChem for chemical match using the InChIKey VWXRQYYUEIYXCZ-OBIMUBPZSA-N
Search UniChem for chemicals with the same backbone VWXRQYYUEIYXCZ
Wikipedia Atosiban

Product suppliers

View disclaimer

Tocris
Atosiban
Cat. No. 6332