EHT 1864 [Ligand Id: 11059] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1186585
  • Ras-related C3 botulinum toxin substrate 1 in Human [ChEMBL: CHEMBL6094] [UniProtKB: P63000]
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  • Ras-related C3 botulinum toxin substrate 2 in Human [ChEMBL: CHEMBL5581] [UniProtKB: P15153]
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  • Ras-related C3 botulinum toxin substrate 3 in Human [ChEMBL: CHEMBL6087] [UniProtKB: P60763]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Ras-related C3 botulinum toxin substrate 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6094] [UniProtKB: P63000]
ChEMBL Binding affinity to Rac1b (unknown origin) assessed as dissociation constant B 7.3 pKd 50 nM Kd Bioorg Med Chem (2023) 90: 117337-117337 [PMID:37253305]
ChEMBL Binding affinity to Rac1 (unknown origin) expressed in Escherichia coli BL21 (DE3) cells assessed as dissociation constant by fluorescence anisotropy assay B 7.4 pKd 40 nM Kd Bioorg Med Chem (2023) 90: 117337-117337 [PMID:37253305]
Ras-related C3 botulinum toxin substrate 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5581] [UniProtKB: P15153]
ChEMBL Binding affinity to Rac2 (unknown origin) assessed as dissociation constant B 7.22 pKd 60 nM Kd Bioorg Med Chem (2023) 90: 117337-117337 [PMID:37253305]
Ras-related C3 botulinum toxin substrate 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6087] [UniProtKB: P60763]
ChEMBL Binding affinity to Rac3 (unknown origin) assessed as dissociation constant B 6.64 pKd 230 nM Kd Bioorg Med Chem (2023) 90: 117337-117337 [PMID:37253305]

ChEMBL data shown on this page come from version 35:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]