ethionamide [Ligand Id: 12954] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1441 (1314 TH, 1314-TH, BAYER 5312, Ethionamide, Ethionamidum, Etionamida, Nizotin, NSC-255115, Trecator, Trecator-sc)
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Tyrosinase in Agaricus bisporus (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3318] [UniProtKB: O42713]
ChEMBL Non-competitive inhibition of mushroom tyrosinase using L-tyrosine as substrate by Lineweaver-Burk plots analysis B 5.72 pKi 1.9 uM Kic Eur J Med Chem (2015) 106: 157-166 [PMID:26544630]
ChEMBL Inhibition of mushroom tyrosinase using L-tyrosine as substrate B 5.4 pIC50 4000 nM IC50 Eur J Med Chem (2015) 106: 157-166 [PMID:26544630]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]