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ChEMBL ligand: CHEMBL444278 (MRS-2500) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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P2Y1 receptor/Purinergic receptor P2Y1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4315] [GtoPdb: 323] [UniProtKB: P47900] | ||||||||
GtoPdb | - | - | 9.1 | pKi | - | - | - |
Biochem Pharmacol (2004) 68: 1995-2002 [PMID:15476670]; J Med Chem (2003) 46: 4974-87 [PMID:14584948] |
ChEMBL | Inhibition of [3H]5 binding to P2Y purinoceptor 1 expressed in Sf9 cells | B | 9.11 | pKi | 0.78 | nM | Ki | J. Med. Chem. (2003) 46: 4974-4987 [PMID:14584948] |
ChEMBL | Binding affinity to human P2Y1 receptor | B | 9.11 | pKi | 0.78 | nM | Ki | Bioorg. Med. Chem. Lett. (2008) 18: 3338-3343 [PMID:18445527] |
ChEMBL | Displacement of [3H]2-chloro-N 6- methyl-( N )-methanocarba-2'-deoxyadenosine 3 ' ,5 '-bis-phosphate from human P2Y1 expressed in baculovirus infected insect Sf9 cells after 30 mins by scintillation spectrometric method | B | 9.11 | pKi | 0.78 | nM | Ki | Eur J Med Chem (2018) 158: 302-310 [PMID:30223118] |
ChEMBL | Antagonistic activity against P2Y purinoceptor 1 | F | 8.08 | pIC50 | 8.4 | nM | IC50 | J. Med. Chem. (2003) 46: 4974-4987 [PMID:14584948] |
ChEMBL data shown on this page come from version 31:
Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]