Click here for a description of the charts and data table
Please tell us if you are using this feature and what you think!
ChEMBL ligand: CHEMBL2374220 (GS-5885, Ledipasvir, Ledipasvir acetonate) |
---|
There should be some charts here, you may need to enable JavaScript!
|
DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
---|---|---|---|---|---|---|---|---|
Nonstructural protein 5A in Hepatitis C virus (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3307224] [UniProtKB: Q5L478] | ||||||||
ChEMBL | Inhibition of NS5A in HCV genotype 3a by cell based luciferase reporter gene assay | B | 7.39 | pIC50 | 41 | nM | IC50 | J Med Chem (2019) 62: 10563-10582 [PMID:31710479] |
ChEMBL | Inhibition of NS5A in HCV genotype 2a JFH-1 by cell based luciferase reporter gene assay | B | 7.68 | pIC50 | 21 | nM | IC50 | J Med Chem (2019) 62: 10563-10582 [PMID:31710479] |
ChEMBL | Inhibition of NS5A R44K mutant in HCV genotype 2b infected in human HuH7 replicon cells assessed as reduction in viral replication after 3 days by luciferase reporter gene assay | B | 6.03 | pEC50 | 943 | nM | EC50 | Bioorg Med Chem Lett (2019) 29: 2415-2427 [PMID:31230974] |
ChEMBL | Inhibition of NS5A in wild type HCV genotype 2b MD2b-1 infected in human HuH7 replicon cells assessed as reduction in viral replication after 3 days by luciferase reporter gene assay | B | 6.06 | pEC50 | 865 | nM | EC50 | Bioorg Med Chem Lett (2019) 29: 2415-2427 [PMID:31230974] |
ChEMBL | Inhibition of NS5A in HCV genotype 2b MD2b-1 infected in human HuH7 replicon cells assessed as reduction in viral replication after 3 days by luciferase reporter gene assay | B | 6.28 | pEC50 | 530 | nM | EC50 | Bioorg Med Chem Lett (2019) 29: 2415-2427 [PMID:31230974] |
ChEMBL | Inhibition of NS5A P58S mutant in HCV genotype 2b infected in human HuH7 replicon cells assessed as reduction in viral replication after 3 days by luciferase reporter gene assay | B | 6.53 | pEC50 | 292 | nM | EC50 | Bioorg Med Chem Lett (2019) 29: 2415-2427 [PMID:31230974] |
ChEMBL | Inhibition of NS5A in HCV genotype 6e D88 infected in human HuH7 replicon cells assessed as reduction in viral replication after 3 days by luciferase reporter gene assay | B | 6.58 | pEC50 | 264 | nM | EC50 | Bioorg Med Chem Lett (2019) 29: 2415-2427 [PMID:31230974] |
ChEMBL | Inhibition of NS5A in HCV genotype 2a J6 infected in human HuH7 replicon cells assessed as reduction in viral replication after 3 days by luciferase reporter gene assay | B | 6.6 | pEC50 | 249 | nM | EC50 | Bioorg Med Chem Lett (2019) 29: 2415-2427 [PMID:31230974] |
ChEMBL | Inhibition of NS5A N62V mutant in HCV genotype 2a infected in human HuH7 replicon cells assessed as reduction in viral replication after 3 days by luciferase reporter gene assay | B | 6.65 | pEC50 | 222 | nM | EC50 | Bioorg Med Chem Lett (2019) 29: 2415-2427 [PMID:31230974] |
ChEMBL | Inhibition of NS5A in wild type HCV genotype 2b AY232738 infected in human HuH7 replicon cells assessed as reduction in viral replication after 3 days by luciferase reporter gene assay | B | 6.68 | pEC50 | 211 | nM | EC50 | Bioorg Med Chem Lett (2019) 29: 2415-2427 [PMID:31230974] |
ChEMBL | Inhibition of NS5A in HCV wild type genotype 2a infected in human HuH7 replicon cells assessed as reduction in viral replication after 3 days by luciferase reporter gene assay | B | 6.68 | pEC50 | 209 | nM | EC50 | Bioorg Med Chem Lett (2019) 29: 2415-2427 [PMID:31230974] |
ChEMBL | Inhibition of NS5A Q30E mutant in HCV genotype 1a infected in human HuH7 replicon cells assessed as reduction in viral replication after 3 days by luciferase reporter gene assay | B | 6.77 | pEC50 | 169 | nM | EC50 | Bioorg Med Chem Lett (2019) 29: 2415-2427 [PMID:31230974] |
ChEMBL | Inhibition of NS5A in HCV genotype 3a S52 infected in human HuH7 replicon cells assessed as reduction in viral replication after 3 days by luciferase reporter gene assay | B | 6.77 | pEC50 | 168 | nM | EC50 | Bioorg Med Chem Lett (2019) 29: 2415-2427 [PMID:31230974] |
ChEMBL | Inhibition of NS5A K44R mutant in HCV genotype 2a infected in human HuH7 replicon cells assessed as reduction in viral replication after 3 days by luciferase reporter gene assay | B | 6.79 | pEC50 | 164 | nM | EC50 | Bioorg Med Chem Lett (2019) 29: 2415-2427 [PMID:31230974] |
ChEMBL | Inhibition of NS5A N62S mutant in HCV genotype 2a infected in human HuH7 replicon cells assessed as reduction in viral replication after 3 days by luciferase reporter gene assay | B | 6.91 | pEC50 | 123 | nM | EC50 | Bioorg Med Chem Lett (2019) 29: 2415-2427 [PMID:31230974] |
ChEMBL | Inhibition of NS5A A30K mutant in HCV genotype 3a infected in human HuH7 replicon cells assessed as reduction in viral replication after 3 days by luciferase reporter gene assay | B | 7.05 | pEC50 | >88.8 | nM | EC50 | Bioorg Med Chem Lett (2019) 29: 2415-2427 [PMID:31230974] |
ChEMBL | Inhibition of NS5A Y93H mutant in HCV genotype 3a infected in human HuH7 replicon cells assessed as reduction in viral replication after 3 days by luciferase reporter gene assay | B | 7.05 | pEC50 | >88.8 | nM | EC50 | Bioorg Med Chem Lett (2019) 29: 2415-2427 [PMID:31230974] |
ChEMBL | Inhibition of NS5A Y93H mutant in HCV genotype 1a infected in human HuH7 replicon cells assessed as reduction in viral replication after 3 days by luciferase reporter gene assay | B | 7.28 | pEC50 | 52 | nM | EC50 | Bioorg Med Chem Lett (2019) 29: 2415-2427 [PMID:31230974] |
ChEMBL | Inhibition of NS5A Y93C mutant in HCV genotype 1a infected in human HuH7 replicon cells assessed as reduction in viral replication after 3 days by luciferase reporter gene assay | B | 7.3 | pEC50 | 49.6 | nM | EC50 | Bioorg Med Chem Lett (2019) 29: 2415-2427 [PMID:31230974] |
ChEMBL | Inhibition of NS5A in wild type HCV genotype 3a infected in human HuH7 replicon cells assessed as reduction in viral replication after 3 days by luciferase reporter gene assay | B | 7.35 | pEC50 | >44.8 | nM | EC50 | Bioorg Med Chem Lett (2019) 29: 2415-2427 [PMID:31230974] |
ChEMBL | Inhibition of NS5A in HCV genotype 2a JFH1 infected in human HuH7 replicon cells assessed as reduction in viral replication after 3 days by luciferase reporter gene assay | B | 7.68 | pEC50 | 21 | nM | EC50 | Bioorg Med Chem Lett (2019) 29: 2415-2427 [PMID:31230974] |
ChEMBL | Inhibition of NS5A Q30R mutant in HCV genotype 1a infected in human HuH7 replicon cells assessed as reduction in viral replication after 3 days by luciferase reporter gene assay | B | 7.71 | pEC50 | 19.6 | nM | EC50 | Bioorg Med Chem Lett (2019) 29: 2415-2427 [PMID:31230974] |
ChEMBL | Inhibition of NS5A L31M mutant in HCV genotype 1a infected in human HuH7 replicon cells assessed as reduction in viral replication after 3 days by luciferase reporter gene assay | B | 7.77 | pEC50 | 17 | nM | EC50 | Bioorg Med Chem Lett (2019) 29: 2415-2427 [PMID:31230974] |
ChEMBL | Inhibition of NS5A Y93H mutant in HCV genotype 1b infected in human HuH7 replicon cells assessed as reduction in viral replication after 3 days by luciferase reporter gene assay | B | 8.14 | pEC50 | 7.2 | nM | EC50 | Bioorg Med Chem Lett (2019) 29: 2415-2427 [PMID:31230974] |
ChEMBL | Inhibition of NS5A Q30H mutant in HCV genotype 1a infected in human HuH7 replicon cells assessed as reduction in viral replication after 3 days by luciferase reporter gene assay | B | 8.24 | pEC50 | 5.7 | nM | EC50 | Bioorg Med Chem Lett (2019) 29: 2415-2427 [PMID:31230974] |
ChEMBL | Inhibition of NS5A M28T mutant in HCV genotype 1a infected in human HuH7 replicon cells assessed as reduction in viral replication after 3 days by luciferase reporter gene assay | B | 8.72 | pEC50 | 1.9 | nM | EC50 | Bioorg Med Chem Lett (2019) 29: 2415-2427 [PMID:31230974] |
ChEMBL | Inhibition of NS5A in HCV genotype 6a HK6 infected in human HuH7 replicon cells assessed as reduction in viral replication after 3 days by luciferase reporter gene assay | B | 8.96 | pEC50 | 1.1 | nM | EC50 | Bioorg Med Chem Lett (2019) 29: 2415-2427 [PMID:31230974] |
ChEMBL | Inhibition of NS5A in HCV genotype 4a ED43 infected in human HuH7 replicon cells assessed as reduction in viral replication after 3 days by luciferase reporter gene assay | B | 9.41 | pEC50 | 0.39 | nM | EC50 | Bioorg Med Chem Lett (2019) 29: 2415-2427 [PMID:31230974] |
ChEMBL | Inhibition of NS5A in HCV genotype 5a SA13 infected in human HuH7 replicon cells assessed as reduction in viral replication after 3 days by luciferase reporter gene assay | B | 9.82 | pEC50 | 0.15 | nM | EC50 | Bioorg Med Chem Lett (2019) 29: 2415-2427 [PMID:31230974] |
ChEMBL | Inhibition of NS5A in wild type HCV genotype 1a infected in human HuH7 replicon cells assessed as reduction in viral replication after 3 days by luciferase reporter gene assay | B | 10.51 | pEC50 | 0.03 | nM | EC50 | Bioorg Med Chem Lett (2019) 29: 2415-2427 [PMID:31230974] |
ChEMBL | Inhibition of NS5A in HCV genotype 1a H77 infected in human HuH7 replicon cells assessed as reduction in viral replication after 3 days by luciferase reporter gene assay | B | 10.51 | pEC50 | 0.03 | nM | EC50 | Bioorg Med Chem Lett (2019) 29: 2415-2427 [PMID:31230974] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]