levosalbutamol [Ligand Id: 9816] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL1002 (Albuterol (r)-form, ASF-1096, Levalbuterol, Levosalbutamol, R-salbutamol, Xopenex) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| β2-adrenoceptor/Beta-2 adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL210] [GtoPdb: 29] [UniProtKB: P07550] | ||||||||
| ChEMBL | Displacement of [3H]-DHA from recombinant human beta2 adrenoceptor expressed in HEK293T cells | B | 5.25 | pKi | 5623.41 | nM | Ki | Bioorg Med Chem (2012) 20: 933-941 [PMID:22182578] |
| ChEMBL | Displacement of [3H]-DHA from recombinant human beta2 adrenoceptor expressed in HEK293T cells | B | 5.25 | pKi | 5623 | nM | Ki | Bioorg Med Chem (2012) 20: 933-941 [PMID:22182578] |
| ChEMBL | Displacement of [3H]-DHA from recombinant human beta2 adrenoceptor expressed in HEK293T cells in presence of 100 uM phenylboronic acid | B | 5.33 | pKi | 4677.35 | nM | Ki | Bioorg Med Chem (2012) 20: 933-941 [PMID:22182578] |
| ChEMBL | Displacement of [3H]-DHA from recombinant human beta2 adrenoceptor expressed in HEK293T cells in presence of 100 uM phenylboronic acid | B | 5.33 | pKi | 4677 | nM | Ki | Bioorg Med Chem (2012) 20: 933-941 [PMID:22182578] |
| ChEMBL | Displacement of [3H]-DHA from recombinant human beta2 adrenoceptor expressed in HEK293T cells in presence of 100 uM boric acid | B | 5.42 | pKi | 3802 | nM | Ki | Bioorg Med Chem (2012) 20: 933-941 [PMID:22182578] |
| ChEMBL | Displacement of [3H]-DHA from recombinant human beta2 adrenoceptor expressed in HEK293T cells in presence of 100 uM boric acid | B | 5.42 | pKi | 3801.89 | nM | Ki | Bioorg Med Chem (2012) 20: 933-941 [PMID:22182578] |
| ChEMBL | Agonist activity at recombinant human beta2 adrenoceptor expressed in HEK293T cells assessed as increase in IBMX-induced cAMP accumulation using [3H]-cAMP after 30 mins by liquid scintillation counting in presence of 100 uM phenylboronic acid | F | 6.34 | pEC50 | 457.09 | nM | EC50 | Bioorg Med Chem (2012) 20: 933-941 [PMID:22182578] |
| ChEMBL | Agonist activity at recombinant human beta2 adrenoceptor expressed in HEK293T cells assessed as increase in IBMX-induced cAMP accumulation using [3H]-cAMP after 30 mins by liquid scintillation counting in presence of 100 uM phenylboronic acid | F | 6.34 | pEC50 | 457 | nM | EC50 | Bioorg Med Chem (2012) 20: 933-941 [PMID:22182578] |
| ChEMBL | Agonist activity at recombinant human beta2 adrenoceptor expressed in HEK293T cells assessed as increase in IBMX-induced cAMP accumulation using [3H]-cAMP after 30 mins by liquid scintillation counting in presence of 100 uM boric acid | F | 6.56 | pEC50 | 275.42 | nM | EC50 | Bioorg Med Chem (2012) 20: 933-941 [PMID:22182578] |
| ChEMBL | Agonist activity at recombinant human beta2 adrenoceptor expressed in HEK293T cells assessed as increase in IBMX-induced cAMP accumulation using [3H]-cAMP after 30 mins by liquid scintillation counting in presence of 100 uM boric acid | F | 6.56 | pEC50 | 275 | nM | EC50 | Bioorg Med Chem (2012) 20: 933-941 [PMID:22182578] |
| ChEMBL | Agonist activity at recombinant human beta2 adrenoceptor expressed in HEK293T cells assessed as increase in IBMX-induced cAMP accumulation using [3H]-cAMP after 30 mins by liquid scintillation counting | F | 6.84 | pEC50 | 145 | nM | EC50 | Bioorg Med Chem (2012) 20: 933-941 [PMID:22182578] |
| ChEMBL | Agonist activity at recombinant human beta2 adrenoceptor expressed in HEK293T cells assessed as increase in IBMX-induced cAMP accumulation using [3H]-cAMP after 30 mins by liquid scintillation counting | F | 6.84 | pEC50 | 144.54 | nM | EC50 | Bioorg Med Chem (2012) 20: 933-941 [PMID:22182578] |
| β1-adrenoceptor in Human [GtoPdb: 28] [UniProtKB: P08588] | ||||||||
| GtoPdb | - | - | 4.7 | pKi | - | - | - | Br J Pharmacol (2010) 160: 1048-61 [PMID:20590599] |
| GtoPdb | - | - | 6.2 | pEC50 | - | - | - | Br J Pharmacol (2010) 160: 1048-61 [PMID:20590599] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
