GW406381 [Ligand Id: 9850] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL364804 (Gw406381, Gw 406381, Gw-406381)
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
COX-1 /Cyclooxygenase-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL221] [GtoPdb: 1375] [UniProtKB: P23219]
GtoPdb - - 4.07 pIC50 >84200 nM IC50 Bioorg Med Chem Lett (2004) 14: 5445-8 [PMID:15454242]
ChEMBL Inhibition of human cyclooxygenase-1 expressed in COS cells B 4.07 pIC50 >84200 nM IC50 Bioorg Med Chem Lett (2004) 14: 5445-5448 [PMID:15454242]
COX-2 /Cyclooxygenase-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL230] [GtoPdb: 1376] [UniProtKB: P35354]
GtoPdb - - 8.52 pIC50 3 nM IC50 Bioorg Med Chem Lett (2004) 14: 5445-8 [PMID:15454242]
ChEMBL Inhibition of human cyclooxygenase-2 expressed in COS cells B 8.52 pIC50 3 nM IC50 Bioorg Med Chem Lett (2004) 14: 5445-5448 [PMID:15454242]
ChEMBL Inhibition of human COX-2 expressed in human COS cells using arachidonic acid as substrate B 8.52 pIC50 3 nM IC50 Eur J Med Chem (2019) 162: 1-17 [PMID:30396033]

ChEMBL data shown on this page come from version 32:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]