ChEMBL ligand: CHEMBL416146 (Arcoxia, Etoricoxib, L-791456, MK-0663)
COX-1 /Cyclooxygenase-1 in Human [ChEMBL: CHEMBL221] [GtoPdb: 1375] [UniProtKB: P23219] Cyclooxygenase-1 in Sheep [ChEMBL: CHEMBL2949] [UniProtKB: P05979] There should be some charts here, you may need to enable JavaScript!
COX-2 /Cyclooxygenase-2 in Human [ChEMBL: CHEMBL230] [GtoPdb: 1376] [UniProtKB: P35354] Cyclooxygenase-2 in Sheep [ChEMBL: CHEMBL4102] [UniProtKB: P79208] There should be some charts here, you may need to enable JavaScript!
mitogen-activated protein kinase 14/MAP kinase p38 alpha in Human [ChEMBL: CHEMBL260] [GtoPdb: 1499] [UniProtKB: Q16539] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
COX-1 /Cyclooxygenase-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL221] [GtoPdb: 1375] [UniProtKB: P23219]
ChEMBL	Inhibition of human cyclooxygenase-1 expressed in COS cells	B	4	pIC50	>100000	nM	IC50	Bioorg Med Chem Lett (2004) 14: 5445-5448 [PMID:15454242]
ChEMBL	In vitro inhibition of Prostaglandin G/H synthase 1 in human whole blood assay	B	4	pIC50	>100000	nM	IC50	Bioorg Med Chem Lett (2001) 11: 1059-1062 [PMID:11327589]
ChEMBL	Inhibition of human COX1 expressed in african green monkey COS cells assessed as inhibition of arachidonic acid-stimulated PGE2 treated 1 hr before arachidonic acid challenge by enzyme immunoassay	B	4	pIC50	>100000	nM	IC50	Bioorg Med Chem Lett (2009) 19: 4504-4508 [PMID:19520573]
ChEMBL	Inhibition of COX1 in human whole blood assessed as inhibition of lipopolysaccharide-induced TxB2 production after 30 min by enzyme immunoassay	B	4	pIC50	>100000	nM	IC50	Bioorg Med Chem Lett (2009) 19: 4504-4508 [PMID:19520573]
ChEMBL	Inhibition concentration against cyclooxygenase-1 (COX-1) in human whole blood	B	4.01	pIC50	98800	nM	IC50	J Med Chem (2004) 47: 3874-3886 [PMID:15239665]
ChEMBL	Inhibition of COX1 in human whole blood assessed as reduction in calcium ionophore-stimulated TXB2 production incubated for 1 hr by ELISA	B	4.03	pIC50	93800	nM	IC50	J Med Chem (2021) 64: 11570-11596 [PMID:34279934]
ChEMBL	Inhibition of Prostaglandin G/H synthase 1 was measured by the inhibition of PGE-2 produced by microsomes from U937 cells at subsaturating arachidonic acid conc.	B	4.92	pIC50	12000	nM	IC50	Bioorg Med Chem Lett (1998) 8: 2777-2782 [PMID:9873621]
Cyclooxygenase-1 in Sheep (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2949] [UniProtKB: P05979]
ChEMBL	Inhibition of ovine COX1 using arachidonic acid as substrate preincubated for 10 mins followed by substrate addition and measured after 2 mins by ELISA	B	4.52	pIC50	>30000	nM	IC50	Medchemcomm (2019) 10: 421-430 [PMID:30996860]
COX-2 /Cyclooxygenase-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL230] [GtoPdb: 1376] [UniProtKB: P35354]
ChEMBL	Inhibition of human recombinant COX-2 using arachidonic acid as substrate preincubated for 60 mins followed by substrate addition for 2 secs by ADPH based fluorometric analysis	B	7.16	pKi	69	nM	Ki	J Med Chem (2021) 64: 11570-11596 [PMID:34279934]
ChEMBL	In vitro inhibitory concentration against Prostaglandin G/H synthase 2 (COX-2) in human whole blood	B	5.7	pIC50	2000	nM	IC50	J Med Chem (2005) 48: 3930-3934 [PMID:15916445]
ChEMBL	Inhibition of Prostaglandin G/H synthase 2 was measured by the inhibition of PGE-2 produced by lipopolysaccharide-challenged HWB	B	5.96	pIC50	1100	nM	IC50	Bioorg Med Chem Lett (1998) 8: 2777-2782 [PMID:9873621]
ChEMBL	In vitro inhibition of Prostaglandin G/H synthase 2 in human whole blood assay	B	5.96	pIC50	1100	nM	IC50	Bioorg Med Chem Lett (2001) 11: 1059-1062 [PMID:11327589]
ChEMBL	Inhibition of human recombinant COX2 using arachidonic acid as substrate preincubated for 5 mins followed by substrate addition and measured after 2 mins by ADPH probe-based fluorescence assay	B	5.96	pIC50	1100	nM	IC50	Eur J Med Chem (2018) 151: 520-532 [PMID:29655084]
GtoPdb	-	-	6	pIC50	1100	nM	IC50	J Pharmacol Exp Ther (2001) 296: 558-66 [PMID:11160644]
ChEMBL	Inhibition of COX2 in human whole blood	B	6.09	pIC50	810	nM	IC50	Bioorg Med Chem Lett (2006) 16: 3605-3608 [PMID:16647258]
ChEMBL	Inhibition of COX2 in human whole blood	B	6.09	pIC50	810	nM	IC50	Bioorg Med Chem Lett (2006) 16: 3209-3212 [PMID:16616494]
ChEMBL	Inhibition concentration against cyclooxygenase-2 (COX-2) in human whole blood	B	6.09	pIC50	810	nM	IC50	J Med Chem (2004) 47: 3874-3886 [PMID:15239665]
ChEMBL	Inhibition of COX2 in human whole blood assessed as reduction in LPS stimulated PGE2 production incubated for 1 hr by ELISA	B	6.21	pIC50	611	nM	IC50	J Med Chem (2021) 64: 11570-11596 [PMID:34279934]
ChEMBL	Inhibition of COX2 (unknown origin) expressed in HEK293 TRex cells assessed as reduction in PGE2 production using arachidonic acid as substrate preincubated for 60 mins followed by substrate addition for 1 hr in presence of 10% FBS by RapidFire High-Throughput Mass Spectrometry	B	6.25	pIC50	560	nM	IC50	J Med Chem (2021) 64: 11570-11596 [PMID:34279934]
ChEMBL	Inhibition of COX2 in human whole blood assessed as inhibition of lipopolysaccharide-stimulated PGE2 production after 24 hrs by enzyme immunoassay	B	6.26	pIC50	554	nM	IC50	Bioorg Med Chem Lett (2009) 19: 4504-4508 [PMID:19520573]
ChEMBL	Inhibition of human recombinant COX-2 assessed as reduction in peroxidase activity using arachidonic acid as substrate preincubated for 60 mins followed by substrate addition for 2 secs by ADPH based fluorometric analysis	B	6.37	pIC50	430	nM	IC50	J Med Chem (2021) 64: 11570-11596 [PMID:34279934]
ChEMBL	Inhibition of human COX2 expressed in african green monkey COS cells assessed as inhibition of arachidonic acid-stimulated PGE2 production treated 1 hr before arachidonic acid challenge by enzyme immunoassay	B	6.46	pIC50	347	nM	IC50	Bioorg Med Chem Lett (2009) 19: 4504-4508 [PMID:19520573]
ChEMBL	Inhibition of human cyclooxygenase-2 expressed in COS cells	B	6.46	pIC50	347	nM	IC50	Bioorg Med Chem Lett (2004) 14: 5445-5448 [PMID:15454242]
ChEMBL	Inhibition of human COX-2 transfected in CHO cells using arachidonic acid as substrate	B	7.09	pIC50	81	nM	IC50	Eur J Med Chem (2019) 162: 1-17 [PMID:30396033]
ChEMBL	In vitro inhibition of PGE-2 produced by arachidonic acid-stimulated CHO cells stably expressing human Prostaglandin G/H synthase 2	B	7.09	pIC50	81	nM	IC50	Bioorg Med Chem Lett (1998) 8: 2777-2782 [PMID:9873621]
ChEMBL	Inhibition of human COX-2 using arachidonic acid as substrate preincubated for 10 mins followed by substrate addition and measured after 2 mins by ELISA	B	7.15	pIC50	70	nM	IC50	RSC Med Chem (2022) 13: 471-496 [PMID:35685617]
Cyclooxygenase-2 in Sheep (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4102] [UniProtKB: P79208]
ChEMBL	Inhibition of ovine COX2 using arachidonic acid as substrate preincubated for 10 mins followed by substrate addition and measured after 2 mins by ELISA	B	6.64	pIC50	230	nM	IC50	Medchemcomm (2019) 10: 421-430 [PMID:30996860]
mitogen-activated protein kinase 14/MAP kinase p38 alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL260] [GtoPdb: 1499] [UniProtKB: Q16539]
ChEMBL	Inhibitory concentration against p38 alpha MAP kinase calculated by CoMFA model; FlexX score = -18.6kcal/mol	B	6.28	pIC50	530	nM	IC50	Bioorg Med Chem Lett (2005) 15: 3506-3509 [PMID:15990304]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]