famitinib   Click here for help

GtoPdb Ligand ID: 7886

Synonyms: compound 9 [PMID: 21028894] | SHR 1020 | SHR-1020 | SHR1020
Compound class: Synthetic organic
Comment: Famitinib is a multi-targeted receptor tyrosine kinase inhibitor [1]. The compound is a structural analogue of sunitinib.
The INN famitinib appeared in Proposed List 125 which was published by the WHO at the end of July 2021.
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 5
Hydrogen bond donors 2
Rotatable bonds 6
Topological polar surface area 68.44
Molecular weight 410.21
XLogP 2.59
No. Lipinski's rules broken 0
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Canonical SMILES CCN(CCN1CCc2c(C1=O)c(C)c([nH]2)C=C1C(=O)Nc2c1cc(F)cc2)CC
Isomeric SMILES CCN(CCN1CCc2c(C1=O)c(C)c([nH]2)/C=C/1\C(=O)Nc2c1cc(F)cc2)CC
InChI InChI=1S/C23H27FN4O2/c1-4-27(5-2)10-11-28-9-8-19-21(23(28)30)14(3)20(25-19)13-17-16-12-15(24)6-7-18(16)26-22(17)29/h6-7,12-13,25H,4-5,8-11H2,1-3H3,(H,26,29)/b17-13-
Classification Click here for help
Compound class Synthetic organic
IUPAC Name Click here for help
International Nonproprietary Names Click here for help
INN number INN
11724 famitinib
Synonyms Click here for help
compound 9 [PMID: 21028894] | SHR 1020 | SHR-1020 | SHR1020
Database Links Click here for help
CAS Registry No. 945380-27-8
ChEMBL Ligand CHEMBL1278146
GtoPdb PubChem SID 249565577
PubChem CID 16662431
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