ezutromid [Ligand Id: 11110] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1773683 (BMN 195, BMN-195, BMN195, Ezutromid, Smt c1100, SMT-C1100, SMTC-1100)
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Aryl hydrocarbon receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3201] [GtoPdb: 2951] [UniProtKB: P35869]
GtoPdb apparent binding affinity determined using affinity‐based protein profiling (AfBPP), in a cellular context. - 7.3 pKd 50 nM Kd Angew Chem Int Ed Engl (2020) 59: 2420-2428 [PMID:31755636]
ChEMBL Binding affinity to AhR (unknown origin) assessed as dissociation constant B 7.3 pKd 50 nM Kd Eur J Med Chem (2022) 244: 114845-114845 [PMID:36274276]
Utrophin in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4523230] [UniProtKB: P46939]
ChEMBL Modulation of human utrophinA expressed in mouse H2K cells assessed as upregulation of utrophin production after 24 hrs by luciferase reporter gene assay B 6.73 pEC50 187 nM EC50 J Med Chem (2020) 63: 7880-7891 [PMID:32551645]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]