Click here for a description of the charts and data table
Please tell us if you are using this feature and what you think!
ChEMBL ligand: CHEMBL3613749 |
---|
There should be some charts here, you may need to enable JavaScript!
|
DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
---|---|---|---|---|---|---|---|---|
protein phosphatase, Mg2+/Mn2+ dependent 1D/Protein phosphatase 1D in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1938224] [GtoPdb: 3134] [UniProtKB: O15297] | ||||||||
ChEMBL | Inhibition of His-tagged PPM1D (1 to 420 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) pLysS cells using Ac-VEPPLS(P)QETFSDLW-NH2 substrate | B | 7.06 | pIC50 | 86.3 | nM | IC50 | Bioorg Med Chem (2015) 23: 6246-6249 [PMID:26358280] |
GtoPdb | Inhibition of PPM1D phosphatase activity determined using recombinant His-PPM1D(1-420) and a phosphorylated peptide derived from p53 as the substrate. | - | 7.07 | pIC50 | 86 | nM | IC50 | Bioorg Med Chem (2015) 23: 6246-9 [PMID:26358280] |
GtoPdb | Inhibition of dephosphorylation of Thr180 of the endogenous substrate phospho-p38 MAPK in vitro. | - | 7.89 | pIC50 | 13 | nM | IC50 | Nat Chem Biol (2014) 10: 181-7 [PMID:24390428] |
ChEMBL | Inhibition of human Wip1 (2 to 420 residues) expressed in baculovirus-infected insect SF9 cells assessed as fluorescein diphosphate hydrolysis after 5 mins by fluorescence assay | B | 8.22 | pIC50 | 6 | nM | IC50 | J Med Chem (2016) 59: 6629-6644 [PMID:26914744] |
ChEMBL | Allosteric inhibition of human Wip1 (2 to 420 residues) expressed in baculovirus infected sf9 cells using FDP as substrate by fluorescence method | B | 8.22 | pIC50 | 6 | nM | IC50 | J Med Chem (2020) 63: 11368-11396 [PMID:32460492] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]