morin [Ligand Id: 411] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL28626 (NSC-19801)
  • 3-oxoacyl-acyl-carrier protein reductase in Plasmodium falciparum [ChEMBL: CHEMBL4513] [UniProtKB: Q965D6]
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  • A1 receptor/Adenosine A1 receptor in Rat [ChEMBL: CHEMBL318] [GtoPdb: 18] [UniProtKB: P25099]
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  • A3 receptor/Adenosine A3 receptor in Human [ChEMBL: CHEMBL256] [GtoPdb: 21] [UniProtKB: P0DMS8]
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  • Alpha-glucosidase MAL62 in Saccharomyces cerevisiae [ChEMBL: CHEMBL4357] [UniProtKB: P07265]
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  • ABCG2/ATP-binding cassette sub-family G member 2 in Human [ChEMBL: CHEMBL5393] [GtoPdb: 792] [UniProtKB: Q9UNQ0]
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  • beta-secretase 1/Beta-secretase 1 in Human [ChEMBL: CHEMBL4822] [GtoPdb: 2330] [UniProtKB: P56817]
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  • casein kinase 2, alpha prime polypeptide subunit/casein kinase 2, beta polypeptide subunit/casein kinase 2, alpha 1 polypeptide subunit/Casein kinase II in Human [ChEMBL: CHEMBL2095191] [GtoPdb: 155015511549] [UniProtKB: P19784P67870P68400]
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  • death associated protein kinase 1/Death-associated protein kinase 1 in Human [ChEMBL: CHEMBL2558] [GtoPdb: 2002] [UniProtKB: P53355]
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  • Enoyl-acyl-carrier protein reductase in Plasmodium falciparum [ChEMBL: CHEMBL4150] [UniProtKB: Q965D5]
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  • Fatty acid synthase in Plasmodium falciparum [ChEMBL: CHEMBL4512] [UniProtKB: Q965D7]
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  • Human immunodeficiency virus type 1 integrase in Human immunodeficiency virus 1 [ChEMBL: CHEMBL3471] [UniProtKB: Q7ZJM1]
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  • Low molecular weight phosphotyrosine protein phosphatase in Bovine [ChEMBL: CHEMBL1075054] [UniProtKB: P11064]
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  • RTP Type S/Receptor-type tyrosine-protein phosphatase S in Human [ChEMBL: CHEMBL2396508] [GtoPdb: 1866] [UniProtKB: Q13332]
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  • Pim-1 proto-oncogene, serine/threonine kinase/Serine/threonine-protein kinase PIM1 in Human [ChEMBL: CHEMBL2147] [GtoPdb: 2158] [UniProtKB: P11309]
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  • polo like kinase 1/Serine/threonine-protein kinase PLK1 in Human [ChEMBL: CHEMBL3024] [GtoPdb: 2168] [UniProtKB: P53350]
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  • Urate anion exchanger 1/Solute carrier family 22 member 12 in Human [ChEMBL: CHEMBL6120] [GtoPdb: 1031] [UniProtKB: Q96S37]
  • Urate anion exchanger 1/Solute carrier family 22 member 12 in Rat [ChEMBL: CHEMBL1075239] [GtoPdb: 1031] [UniProtKB: Q3ZAV1]
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  • spleen associated tyrosine kinase/Tyrosine-protein kinase SYK in Human [ChEMBL: CHEMBL2599] [GtoPdb: 2230] [UniProtKB: P43405]
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  • xanthine dehydrogenase/Xanthine dehydrogenase in Human [ChEMBL: CHEMBL1929] [GtoPdb: 2646] [UniProtKB: P47989]
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  • A2A receptor in Human [GtoPdb: 19] [UniProtKB: P29274]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
3-oxoacyl-acyl-carrier protein reductase in Plasmodium falciparum (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4513] [UniProtKB: Q965D6]
ChEMBL Inhibition of FabG B 5.64 pIC50 2300 nM IC50 J. Med. Chem. (2006) 49: 3345-3353 [PMID:16722653]
A1 receptor/Adenosine A1 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL318] [GtoPdb: 18] [UniProtKB: P25099]
ChEMBL Binding affinity at Adenosine A1 receptor in rat brain membranes by [3H]PIA displacement. B 4.86 pKi 13800 nM Ki J. Med. Chem. (1996) 39: 2293-2301 [PMID:8691424]
GtoPdb - - 4.9 pKi - - - J. Med. Chem. (1996) 39: 2293-301 [PMID:8691424]
A3 receptor/Adenosine A3 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL256] [GtoPdb: 21] [UniProtKB: P0DMS8]
ChEMBL Binding affinity against human adenosine A3 receptor in HEK293 cells using [125I]AB-MECA 21680 radioligand. B 4.47 pKi 34000 nM Ki J. Med. Chem. (1996) 39: 2293-2301 [PMID:8691424]
Alpha-glucosidase MAL62 in Saccharomyces cerevisiae (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4357] [UniProtKB: P07265]
ChEMBL Inhibition of baker's yeast alpha-glucosidase using p-nitrophenyl-alpha-D-glucopyranoside as substrate by spectrophotometry B 1.6 pIC50 1.6 - logIC50 Med Chem Res (2012) 21: 3984-3993
ABCG2/ATP-binding cassette sub-family G member 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5393] [GtoPdb: 792] [UniProtKB: Q9UNQ0]
ChEMBL Inhibition of BCRP expressed in MCF-7 MX cells using Hoechst 33342 staining B 4.31 pIC50 49000 nM IC50 Bioorg. Med. Chem. (2011) 19: 2090-2102 [PMID:21354800]
ChEMBL Inhibition of BCRP expressed in MDCK cells using Hoechst 33342 staining B 4.68 pIC50 21000 nM IC50 Bioorg. Med. Chem. (2011) 19: 2090-2102 [PMID:21354800]
Beta amyloid A4 protein in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2487] [UniProtKB: P05067]
ChEMBL Inhibition of wild type Amyloid beta (1 to 42) (unknown origin) aggregation by Thioflavin-T fluorescence assay B 4.52 pIC50 30300 nM IC50 Bioorg. Med. Chem. (2016) 24: 304-313 [PMID:26719209]
beta-secretase 1/Beta-secretase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4822] [GtoPdb: 2330] [UniProtKB: P56817]
ChEMBL Inhibition of BACE1 (unknown origin) B 4.66 pIC50 21700 nM IC50 Med Chem Res (2013) 22: 3061-3075
ChEMBL Inhibition of human recombinant BACE-1 expressed in HEK293 cells assessed as inhibition of amyloid precursor protein cleavage into amyloid beta after 60 mins using Rh-EVNLDAEFK-Quencher as a substrate by FRET assay B 4.91 pIC50 12300 nM IC50 Bioorg. Med. Chem. Lett. (2011) 21: 2945-2948 [PMID:21511472]
casein kinase 2, alpha prime polypeptide subunit/casein kinase 2, beta polypeptide subunit/casein kinase 2, alpha 1 polypeptide subunit/Casein kinase II in Human (target type: PROTEIN COMPLEX GROUP) [ChEMBL: CHEMBL2095191] [GtoPdb: 155015511549] [UniProtKB: P19784P67870P68400]
ChEMBL Inhibition of recombinant human CK2 expressed in Escherichia coli using RRRADDSDDDDD as substrate after 10 mins B 5 pIC50 10000 nM IC50 J. Med. Chem. (2015) 58: 7400-7408 [PMID:26322379]
death associated protein kinase 1/Death-associated protein kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2558] [GtoPdb: 2002] [UniProtKB: P53355]
ChEMBL Inhibition of DAPK1 (unknown origin) using ZIPtide as substrate by fluorescence assay in presence of ATP, MgCl2 B 4.96 pIC50 11000 nM IC50 J. Med. Chem. (2015) 58: 7400-7408 [PMID:26322379]
ChEMBL Displacement of ANS from DAPK1 catalytic domain (1 to 285) (unknown origin) after 30 mins by fluorescence assay B 5.8 pIC50 1600 nM IC50 J. Med. Chem. (2015) 58: 7400-7408 [PMID:26322379]
Enoyl-acyl-carrier protein reductase in Plasmodium falciparum (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4150] [UniProtKB: Q965D5]
ChEMBL Inhibition of FabI B 5.3 pIC50 5000 nM IC50 J. Med. Chem. (2006) 49: 3345-3353 [PMID:16722653]
Fatty acid synthase in Plasmodium falciparum (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4512] [UniProtKB: Q965D7]
ChEMBL Inhibition of FabZ B 5.1 pIC50 8000 nM IC50 J. Med. Chem. (2006) 49: 3345-3353 [PMID:16722653]
GPR35/G-protein coupled receptor 35 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1293267] [GtoPdb: 102] [UniProtKB: Q9HC97]
ChEMBL Desensitization of GPR35 receptor in human HT-29 cells assessed as inhibition of zaprinast-induced dynamic mass redistribution after 10 mins B 5.8 pIC50 1600 nM IC50 ACS Med. Chem. Lett. (2012) 3: 165-169 [PMID:24900447]
ChEMBL Agonist activity at GPR35 receptor in human U2OS cells coexpressing Gal4-VP16-TEV assessed as beta arrestin translocation after 5 hrs by beta lactamase reporter gene assay F 4.95 pEC50 11200 nM EC50 ACS Med. Chem. Lett. (2012) 3: 165-169 [PMID:24900447]
ChEMBL Agonist activity at GPR35 receptor in human HT-29 cells after 10 mins by dynamic mass redistribution assay F 5.88 pEC50 1330 nM EC50 ACS Med. Chem. Lett. (2012) 3: 165-169 [PMID:24900447]
Human immunodeficiency virus type 1 integrase in Human immunodeficiency virus 1 (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3471] [UniProtKB: Q7ZJM1]
ChEMBL IC50 was measured as concentration required to inhibit 50% of HIV-integrase cleavage B 4.12 pIC50 76500 nM IC50 J. Med. Chem. (1995) 38: 890-897 [PMID:7699704]
ChEMBL IC50 was measured as concentration required to inhibit 50% of HIV-integrase integration B 4.5 pIC50 31700 nM IC50 J. Med. Chem. (1995) 38: 890-897 [PMID:7699704]
Low molecular weight phosphotyrosine protein phosphatase in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075054] [UniProtKB: P11064]
ChEMBL Inhibition of bovine kidney LMW-PTPase using phosphotyrosine substrate B 5 pIC50 10000 nM IC50 J. Med. Chem. (2012) 55: 2-22 [PMID:21988196]
Pancreatic triacylglycerol lipase in Pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1687677] [UniProtKB: P00591]
ChEMBL Inhibition of porcine pancreatic lipase pre-incubated for 15 mins before p-nitrophenylbutyrate substrate addition by microplate reader based method B 4 pIC50 >100000 nM IC50 Bioorg. Med. Chem. Lett. (2015) 25: 3455-3457 [PMID:26227773]
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364]
ChEMBL Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum K1 F 4.79 pIC50 16100 nM IC50 J. Med. Chem. (2006) 49: 3345-3353 [PMID:16722653]
Protein E6 in Human papillomavirus type 16 (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2010633] [UniProtKB: P03126]
ChEMBL Inhibition of GST-tagged Human papillomavirus 16 protein E6 interaction with His-tagged human caspase 8 expressed in Escherichia coli after 1 hr incubation followed by overnight incubation by Alpha screening technique B 5.4 pIC50 4000 nM IC50 Bioorg. Med. Chem. Lett. (2012) 22: 2125-2129 [PMID:22300659]
RTP Type S/Receptor-type tyrosine-protein phosphatase S in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2396508] [GtoPdb: 1866] [UniProtKB: Q13332]
ChEMBL Inhibition of recombinant human PTP-sigma (residues 1367 to 1948) using para-nitrophenylphosphate as substrate for 60 mins by fluorescence analysis B 5.37 pIC50 4300 nM IC50 Bioorg. Med. Chem. Lett. (2016) 26: 87-93 [PMID:26602279]
Pim-1 proto-oncogene, serine/threonine kinase/Serine/threonine-protein kinase PIM1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2147] [GtoPdb: 2158] [UniProtKB: P11309]
ChEMBL Inhibition of PIM1 kinase B 0.43 pIC50 -0.43 uM -Log IC50 Bioorg. Med. Chem. (2007) 15: 6463-6473 [PMID:17637507]
polo like kinase 1/Serine/threonine-protein kinase PLK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3024] [GtoPdb: 2168] [UniProtKB: P53350]
ChEMBL Inhibition of PLK1 B 4.9 pIC50 12600 nM IC50 Bioorg. Med. Chem. Lett. (2008) 18: 4972-4977 [PMID:18762425]
Urate anion exchanger 1/Solute carrier family 22 member 12 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6120] [GtoPdb: 1031] [UniProtKB: Q96S37]
ChEMBL Inhibition of human URAT1-mediated urate uptake in HEK293 cells by competitive inhibition assay B 5.24 pKi 5740 nM Ki Drug Metab. Dispos. (2007) 35: 981-986 [PMID:17325024]
ChEMBL Inhibition of human URAT1-mediated urate uptake in HEK293 cells B 5.7 pIC50 2000 nM IC50 Drug Metab. Dispos. (2007) 35: 981-986 [PMID:17325024]
Urate anion exchanger 1/Solute carrier family 22 member 12 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075239] [GtoPdb: 1031] [UniProtKB: Q3ZAV1]
ChEMBL Inhibition of human URAT1-mediated urate uptake in rat renal brush border membrane vesicles B 4.74 pIC50 18000 nM IC50 Drug Metab. Dispos. (2007) 35: 981-986 [PMID:17325024]
Sortase A in S.aureus (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5362] [UniProtKB: Q9S446]
ChEMBL Inhibition of 6-His tagged Staphylococcus aureus recombinant sortase delta N24 expressed in Escherichia coli BL21 (DE3) B 4.43 pIC50 37390 nM IC50 Bioorg. Med. Chem. (2009) 17: 2886-2893 [PMID:19269184]
tubulin beta class I/tubulin alpha 4a/tubulin beta 4B class IVb/tubulin beta 3 class III/tubulin beta 8 class VIII/tubulin alpha 1a/Tubulin in Human (target type: PROTEIN COMPLEX GROUP) [ChEMBL: CHEMBL2095182] [GtoPdb: 264026392641275227532638] [UniProtKB: P04350P07437P0DPH7P68363P68366P68371Q13509Q13885Q3ZCM7Q6PEY2Q71U36Q9BQE3Q9BUF5Q9BVA1Q9H4B7]
ChEMBL Displacement of [3H]colchicine from tubulin (unknown origin) B 4 pKd >100000 nM Kd J. Med. Chem. (2013) 56: 7382-7395 [PMID:23961916]
spleen associated tyrosine kinase/Tyrosine-protein kinase SYK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2599] [GtoPdb: 2230] [UniProtKB: P43405]
ChEMBL Inhibition of SYK B 4.55 pIC50 28000 nM IC50 J. Med. Chem. (2012) 55: 3614-3643 [PMID:22257213]
xanthine dehydrogenase/Xanthine dehydrogenase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1929] [GtoPdb: 2646] [UniProtKB: P47989]
ChEMBL Inhibition of xanthine oxidase assessed as decrease in uric acid production by spectrophotometry B 5 pIC50 10100 nM IC50 J. Nat. Prod. (1998) 61: 71-76 [PMID:9461655]
A2A receptor in Human [GtoPdb: 19] [UniProtKB: P29274]
GtoPdb - - 4.8 pKi - - - J. Med. Chem. (1996) 39: 2293-301 [PMID:8691424]

ChEMBL data shown on this page come from version 27:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]