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Target not currently curated in GtoImmuPdb
Target id: 1031
Nomenclature: Urate anion exchanger 1
Abbreviated Name: URAT1
Systematic Nomenclature: SLC22A12
Family: Urate transporter
Gene and Protein Information  |
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| Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
| Human | 12 | 553 | 11q13.1 | SLC22A12 | solute carrier family 22 member 12 | |
| Mouse | 12 | 553 | 19 A | Slc22a12 | solute carrier family 22 (organic anion/cation transporter), member 12 | |
| Rat | 12 | 553 | 1q43 | Slc22a12 | solute carrier family 22 member 12 | |
| Previous and Unofficial Names |
| organic anion transporter 4-like protein | Renal-specific transporter | RST | OAT4L | solute carrier family 22 (organic anion/cation transporter), member 12 | solute carrier family 22 (organic anion/urate transporter), member 12 | solute carrier family 22 (organic anion/cation transporter) |
| Database Links |
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| Specialist databases | |
| Bioparadigms SLC Tables | SLC22A12 (Hs) |
| RESOLUTE | SLC22A12 (Hs) |
| Other databases | |
| Alphafold | Q96S37 (Hs), Q8CFZ5 (Mm), Q3ZAV1 (Rn) |
| ChEMBL Target | CHEMBL6120 (Hs), CHEMBL1075239 (Rn) |
| Ensembl Gene | ENSG00000197891 (Hs), ENSMUSG00000061742 (Mm), ENSRNOG00000021108 (Rn) |
| Entrez Gene | 116085 (Hs), 20521 (Mm), 365398 (Rn) |
| Human Protein Atlas | ENSG00000197891 (Hs) |
| KEGG Gene | hsa:116085 (Hs), mmu:20521 (Mm), rno:365398 (Rn) |
| OMIM | 607096 (Hs) |
| Pharos | Q96S37 (Hs) |
| UniProtKB | Q96S37 (Hs), Q8CFZ5 (Mm), Q3ZAV1 (Rn) |
| Wikipedia | SLC22A12 (Hs) |
| Stoichiometry |
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| Unknown | |
Download all structure-activity data for this target as a CSV file 
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| Key to terms and symbols | View all chemical structures | Click column headers to sort | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| General Comments |
| URAT1 as a target for the treatment of hyperuricemia of gout is reviewed in [2]. |
1. Burns CM, Wortmann RL. (2011) Gout therapeutics: new drugs for an old disease. Lancet, 377 (9760): 165-77. [PMID:20719377]
2. Diaz-Torné C, Perez-Herrero N, Perez-Ruiz F. (2015) New medications in development for the treatment of hyperuricemia of gout. Curr Opin Rheumatol, 27 (2): 164-9. [PMID:25603039]
3. Taniguchi T, Ashizawa N, Matsumoto K, Saito R, Motoki K, Sakai M, Chikamatsu N, Hagihara C, Hashiba M, Iwanaga T. (2019) Pharmacological Evaluation of Dotinurad, a Selective Urate Reabsorption Inhibitor. J Pharmacol Exp Ther, 371 (1): 162-170. [PMID:31371478]
4. Yu Z, Fong WP, Cheng CH. (2007) Morin (3,5,7,2',4'-pentahydroxyflavone) exhibits potent inhibitory actions on urate transport by the human urate anion transporter (hURAT1) expressed in human embryonic kidney cells. Drug Metab Dispos, 35 (6): 981-6. [PMID:17325024]
